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作者：Wai, Jonathan
作者单位：University of Arkansas System; University of Arkansas Fayetteville
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作者：Loveland, Jasmine L.; Zemella, Alex; Jovanovic, Vladimir M.; Moeller, Gabriele; Sager, Christoph P.; Bastos, Barbara; Dyar, Kenneth A.; Fusani, Leonida; Gahr, Manfred; Giraldo-Deck, Lina M.; Goymann, Wolfgang; Lank, David B.; Tokarz, Janina; Nowick, Katja; Kuepper, Clemens
作者单位：University of Vienna; Free University of Berlin; Free University of Berlin; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Universidade do Porto; University of Veterinary Medicine Vienna; University of Munich; Simon Fraser University
摘要：Androgens are pleiotropic and play pivotal roles in the formation and variation of sexual phenotypes. We show that differences in circulating androgens between the three male mating morphs in ruff sandpipers are linked to 17-beta hydroxysteroid dehydrogenase 2 (HSD17B2), encoded by a gene within the supergene that determines the morphs. Low-testosterone males had higher HSD17B2 expression in blood than high-testosterone males, as well as in brain areas related to social behaviors and testoster...
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作者：Harvey, Lloyd D.; Alotaibi, Mona; Tai, Yi-Yin; Tang, Ying; Kim, Hee-Jung J.; Kelly, Neil J.; Sun, Wei; Woodcock, Chen-Shan C.; Arshad, Sanya; Culley, Miranda K.; El Khoury, Wadih; Xie, Rong; Al Aaraj, Yassmin; Zhao, Jingsi; Hafeez, Neha; Rao, Rashmi J.; Jiang, Siyi; Negi, Vinny; Kirillova, Anna; Perk, Dror; Watson, Annie M.; St Croix, Claudette M.; Stolz, Donna B.; Lee, Ji Young; Cheng, Mary Hongying; Zhang, Manling; Detmer, Samuel; Guzman, Edward; Manan, Rajith S.; Saggar, Rajan; Haley, Kathleen J.; Waxman, Aaron B.; Okawa, Satoshi; Schwantes-An, Tae-Hwi; Pauciulo, Michael W.; Wang, Bing; Webb, Amy; Chauvet, Caroline; Anderson, Daniel G.; Nichols, William C.; Desai, Ankit A.; Lafyatis, Robert; Nouraie, S. Mehdi; Wu, Haodi; McDonald, Jeffrey G.; Cheng, Susan; Bahar, Ivet; Bertero, Thomas; Benza, Raymond L.; Jain, Mohit; Chan, Stephen Y.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Pittsburgh Healthcare System; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Indianapolis; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University System of Ohio; Ohio State University; Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Cedars Sinai Medical Center; Icahn School of Medicine at Mount Sinai
摘要：Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 (NCOA7) deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes. This oxysterol signature overlapped with a plasma metabolite signat...
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作者：Seibel, Shane; Luarkie, Richard; Cardenas, Daniel; Mayer, Cody; Sanchez, Ramon; Dannenberg, Matt; Panek, Bazile Minogiizhigaabo; Bond, Albert; Gordon, Zane; Morishige, Demi; Hadrick, Kourtney; Stahnke, Graham; Fofrich, Robert; Davis, Steve; Tallman, Richard; Bowser, Brooke; Bazilian, Morgan D.
作者单位：Colorado School of Mines; University of California System; University of California Los Angeles; Stanford University
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作者：Duncanson, Laura; Hunka, Neha; Jucker, Tommaso; Armston, John; Harris, Nancy; Fatoyinbo, Lola; Williams, Christopher A.; Atkins, Jeff W.; Raczka, Brett; Serbin, Shawn; Keller, Michael; Dubayah, Ralph; Babcock, Chad; Cochrane, Mark A.; Hudak, Andrew; Hurtt, George C.; Montesano, Paul M.; Moskal, L. Monika; Park, Taejin; Saatchi, Sassan; Silva, Carlos A.; Tang, Hao; Vargas, Rodrigo; Weiskittel, Aaron; Wessels, Konrad; Goetz, Scott J.
作者单位：University System of Maryland; University of Maryland College Park; University of Bristol; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Clark University; United States Department of Agriculture (USDA); United States Forest Service; Virginia Commonwealth University; National Center Atmospheric Research (NCAR) - USA; United States Department of Agriculture (USDA); United States Forest Service; University of Minnesota System; University of Minnesota Twin Cities; University System of Maryland; University of Maryland Center for Environmental Science; United States Department of Agriculture (USDA); United States Forest Service; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Washington; University of Washington Seattle; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; State University System of Florida; University of Florida; National University of Singapore; University of Delaware; University of Maine System; University of Maine Orono; George Mason University; Northern Arizona University
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作者：MacLean, Andrew J.; Deimel, Lachlan P.; Zhou, Pengcheng; ElTanbouly, Mohamed A.; Merkenschlager, Julia; Ramos, Victor; Santos, Gabriela S.; Haeggloef, Thomas; Mayer, Christian T.; Hernandez, Brianna; Gazumyan, Anna; Nussenzweig, Michel C.
作者单位：Rockefeller University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Rockefeller University; Howard Hughes Medical Institute
摘要：Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, is selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown. We found that PC precursors (prePCs) expressing high-affinity antibodies received higher levels of T fol...
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作者：Brainard, Jeffrey
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作者：Pullamsetti, Soni Savai; Savai, Rajkumar
作者单位：Justus Liebig University Giessen; Max Planck Society; Justus Liebig University Giessen
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作者：Zeng, Z.; Foerst, M.; Fechner, M.; Buzzi, M.; Amuah, E. B.; Putzke, C.; Moll, P. J. W.; Prabhakaran, D.; Radaelli, P. G.; Cavalleri, A.
作者单位：Max Planck Society; University of Oxford
摘要：Chirality, a pervasive form of symmetry, is intimately connected to the physical properties of solids, as well as the chemical and biological activity of molecular systems. However, inducing chirality in a nonchiral material is challenging because this requires that all mirrors and all roto-inversions be simultaneously broken. Here, we show that chirality of either handedness can be induced in the nonchiral piezoelectric material boron phosphate (BPO4) by irradiation with terahertz pulses. Res...
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作者：Vogel, Gretchen
