作者：Ma, Jingwen; Yin, Xiaobo
作者单位：University of Hong Kong; University of Hong Kong
作者：Brainard, Jeffrey; Servick, Kelly
作者：Lin, Jing-Ping; Brake, Alexis; Donadieu, Maxime; Lee, Amanda; Smith, Ginger; Hu, Kevin; Nair, Govind; Kawaguchi, Riki; Sati, Pascal; Geschwind, Daniel H.; Jacobson, Steven; Schafer, Dorothy P.; Reich, Daniel S.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Cedars Sinai Medical Center; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
摘要：Inferring cellular and molecular dynamics of multiple sclerosis (MS) lesions from postmortem tissue collected decades after onset is challenging. Using magnetic resonance image (MRI)-guided spatiotemporal RNA profiling in marmoset experimental autoimmune encephalitis (EAE), we mapped lesion dynamics and modeled molecular perturbations relevant to MS. Five distinct lesion microenvironments emerged, involving neuroglial responses, tissue destruction and repair, and brain border regulation. Befor...
作者：Ye, Ziwei; Difonzo, Christina; Hennessy, David A.; Zhao, Jinhua; Wu, Felicia; Conley, Shawn P.; Gassmann, Aaron J.; Hodgson, Erin W.; Jensen, Bryan; Knodel, Janet J.; Mcmanus, Bradley; Meinke, Lance J.; Michel, Andrew; Potter, Bruce; Seiter, Nicholas J.; Smith, Jocelyn L.; Spencer, Joseph L.; Tilmon, Kelley J.; Wright, Robert J.; Krupke, Christian H.
作者单位：Renmin University of China; Michigan State University; Iowa State University; Iowa State University; Cornell University; Michigan State University; Michigan State University; University of Wisconsin System; University of Wisconsin Madison; Iowa State University; University of Wisconsin System; University of Wisconsin Madison; North Dakota State University Fargo; South Dakota State University; University of Nebraska System; University of Nebraska Lincoln; University System of Ohio; Ohio State University; University of Minnesota System; University of Illinois System; University of Illinois Urbana-Champaign; University of Guelph; Illinois Natural History Survey; University of Illinois System; University of Illinois Urbana-Champaign; Purdue University System; Purdue University
摘要：Widespread use of genetically engineered maize targeting the corn rootworm complex (Diabrotica species) has raised concerns about insect resistance. Twelve years of university field trial and farm survey data from 10 US Corn Belt states indicate that maize hybrids expressing toxins derived from the bacterium Bacillus thuringiensis (Bt maize) exhibited declining protection from rootworm feeding with increased planting while pest pressures simultaneously decreased. The analysis revealed a tenden...
