8007期

最新文章

• Heat and desiccation tolerances predict bee abundance under climate change AI翻译
  作者：Kazenel, Melanie R.; Wright, Karen W.; Griswold, Terry; Whitney, Kenneth D.; Rudgers, Jennifer A.
  作者单位：University of New Mexico; United States Department of Agriculture (USDA); Utah System of Higher Education; Utah State University
  摘要：Climate change could pose an urgent threat to pollinators, with critical ecological and economic consequences. However, for most insect pollinator species, we lack the long-term data and mechanistic evidence that are necessary to identify climate-driven declines and predict future trends. Here we document 16 years of abundance patterns for a hyper-diverse bee assemblage1 in a warming and drying region2, link bee declines with experimentally determined heat and desiccation tolerances, and use c...
• Transcription-replication conflicts underlie sensitivity to PARP inhibitors AI翻译
  作者：Petropoulos, Michalis; Karamichali, Angeliki; Rossetti, Giacomo G.; Freudenmann, Alena; Iacovino, Luca G.; Dionellis, Vasilis S.; Sotiriou, Sotirios K.; Halazonetis, Thanos D.
  作者单位：University of Geneva; Roche Holding
  摘要：An important advance in cancer therapy has been the development of poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of homologous recombination (HR)-deficient cancers(1-6). PARP inhibitors trap PARPs on DNA. The trapped PARPs are thought to block replisome progression, leading to formation of DNA double-strand breaks that require HR for repair(7). Here we show that PARP1 functions together with TIMELESS and TIPIN to protect the replisome in early S phase from transcription-repli...
• Melting ice solves leap-second problem - for now AI翻译
  作者：Tavella, Patrizia; Mitrovica, Jerry X.
  作者单位：Harvard University
  摘要：Humans' effect on the polar ice sheets is slowing Earth's rotation, posing challenges for its alignment with the official time standard. Two researchers discuss the science behind the slowdown and the impact it has on timekeeping.
• 'Without these tools, I'd be lost': how generative AI aids in accessibility AI翻译
  作者：Heidt, Amanda
• Brazil's postgrad funding model can promote equity AI翻译
  作者：Quintans-Junior, Lucindo J.
  作者单位：Universidade Federal de Sergipe
• Break big tech's stranglehold on AI in academia AI翻译
  作者：Wozniak, Michal; Ksieniewicz, Pawel
  作者单位：Wroclaw University of Science & Technology
• A massive galaxy that formed its stars at z ≈ 11 AI翻译
  作者：Glazebrook, Karl; Nanayakkara, Themiya; Schreiber, Corentin; Lagos, Claudia; Kawinwanichakij, Lalitwadee; Jacobs, Colin; Chittenden, Harry; Brammer, Gabriel; Kacprzak, Glenn G.; Labbe, Ivo; Marchesini, Danilo; Marsan, Z. Cemile; Oesch, Pascal A.; Papovich, Casey; Remus, Rhea-Silvia; Tran, Kim-Vy H.; Esdaile, James; Chandro-Gomez, Angel
  作者单位：Swinburne University of Technology; University of Copenhagen; Niels Bohr Institute; University of Western Australia; Tufts University; York University - Canada; University of Geneva; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; University of Munich; University of New South Wales Sydney; Smithsonian Institution
  摘要：The formation of galaxies by gradual hierarchical co-assembly of baryons and cold dark matter halos is a fundamental paradigm underpinning modern astrophysics(1,2) and predicts a strong decline in the number of massive galaxies at early cosmic times(3,4,5). Extremely massive quiescent galaxies (stellar masses of more than 10(11) M-circle dot) have now been observed as early as 1-2 billion years after the Big Bang(6,7,8,9,10,11,12,13). These galaxies are extremely constraining on theoretical mo...
• Digging in: last chance to save a native forest AI翻译
  作者：Sandrini, Dario; Crow, James Mitchell
• THE ANTIDEPRESSANT EFFECT OF LIVING NEAR GREEN SPACE AI翻译
  作者：[Anonymous]
• TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers AI翻译
  作者：Nichakawade, Tushar D.; Ge, Jiaxin; Mog, Brian J.; Lee, Bum Seok; Pearlman, Alexander H.; Hwang, Michael S.; Dinapoli, Sarah R.; Wyhs, Nicolas; Marcou, Nikita; Glavaris, Stephanie; Konig, Maximilian F.; Gabelli, Sandra B.; Watson, Evangeline; Sterling, Cole; Wagner-Johnston, Nina; Rozati, Sima; Swinnen, Lode; Fuchs, Ephraim; Pardoll, Drew M.; Gabrielson, Kathy; Papadopoulos, Nickolas; Bettegowda, Chetan; Kinzler, Kenneth W.; Zhou, Shibin; Sur, Surojit; Vogelstein, Bert; Paul, Suman
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Roche Holding; Roche Holding USA; Genentech; Merck & Company; Merck & Company USA
  摘要：Antibody and chimeric antigen receptor (CAR) T cell-mediated targeted therapies have improved survival in patients with solid and haematologic malignancies1-9. Adults with T cell leukaemias and lymphomas, collectively called T cell cancers, have short survival10,11 and lack such targeted therapies. Thus, T cell cancers particularly warrant the development of CAR T cells and antibodies to improve patient outcomes. Preclinical studies showed that targeting T cell receptor beta-chain constant reg...