作者：Reglade, U.; Bocquet, A.; Gautier, R.; Cohen, J.; Marquet, A.; Albertinale, E.; Pankratova, N.; Hallen, M.; Rautschke, F.; Sellem, L. -A.; Rouchon, P.; Sarlette, A.; Mirrahimi, M.; Campagne-Ibarcq, P.; Lescanne, R.; Jezouin, S.; Leghtas, Z.
作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Ecole Normale Superieure de Lyon (ENS de LYON)
作者：Luo, Qingyu; Raulston, Evangeline G.; Prado, Miguel A.; Wu, Xiaowei; Gritsman, Kira; Whalen, Karley S.; Yan, Kezhi; Booth, Christopher A. G.; Xu, Ran; van Galen, Peter; Doench, John G.; Shimony, Shai; Long, Henry W.; Neuberg, Donna S.; Paulo, Joao A.; Lane, Andrew A.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA); Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Tel Aviv University; Rabin Medical Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Phosphoinositide-3-kinase-gamma (PI3K gamma) is implicated as a target to repolarize tumour-associated macrophages and promote antitumour immune responses in solid cancers1-4. However, cancer cell-intrinsic roles of PI3K gamma are unclear. Here, by integrating unbiased genome-wide CRISPR interference screening with functional analyses across acute leukaemias, we define a selective dependency on the PI3K gamma complex in a high-risk subset that includes myeloid, lymphoid and dendritic lineages....
作者：Makova, Kateryna D.; Pickett, Brandon D.; Harris, Robert S.; Hartley, Gabrielle A.; Cechova, Monika; Pal, Karol; Nurk, Sergey; Yoo, Dongahn; Li, Qiuhui; Hebbar, Prajna; McGrath, Barbara C.; Antonacci, Francesca; Aubel, Margaux; Biddanda, Arjun; Borchers, Matthew; Bornberg-Bauer, Erich; Bouffard, Gerard G.; Brooks, Shelise Y.; Carbone, Lucia; Carrel, Laura; Carroll, Andrew; Chang, Pi-Chuan; Chin, Chen-Shan; Cook, Daniel E.; Craig, Sarah J. C.; de Gennaro, Luciana; Diekhans, Mark; Dutra, Amalia; Garcia, Gage H.; Grady, Patrick G. S.; Green, Richard E.; Haddad, Diana; Hallast, Pille; Harvey, William T.; Hickey, Glenn; Hillis, David A.; Hoyt, Savannah J.; Jeong, Hyeonsoo; Kamali, Kaivan; Pond, Sergei L. Kosakovsky; Lapolice, Troy M.; Lee, Charles; Lewis, Alexandra P.; Loh, Yong-Hwee E.; Masterson, Patrick; Mcgarvey, Kelly M.; Mccoy, Rajiv C.; Medvedev, Paul; Miga, Karen H.; Munson, Katherine M.; Pak, Evgenia; Paten, Benedict; Pinto, Brendan J.; Potapova, Tamara; Rhie, Arang; Rocha, Joana L.; Ryabov, Fedor; Ryder, Oliver A.; Sacco, Samuel; Shafin, Kishwar; Shepelev, Valery A.; Slon, Viviane; Solar, Steven J.; Storer, Jessica M.; Sudmant, Peter H.; Sweeten, Alex; Tassia, Michael G.; Thibaud-Nissen, Francoise; Ventura, Mario; Wilson, Melissa A.; Young, Alice C.; Zeng, Huiqing; Zhang, Xinru; Szpiech, Zachary A.; Huber, Christian D.; Gerton, Jennifer L.; Yi, Soojin V.; Schatz, Michael C.; Alexandrov, Ivan A.; Koren, Sergey; O'Neill, Rachel J.; Eichler, Evan E.; Phillippy, Adam M.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of Connecticut; University of California System; University of California Santa Cruz; University of Washington; University of Washington Seattle; Johns Hopkins University; Universita degli Studi di Bari Aldo Moro; University of Munster; Stowers Institute for Medical Research; Oregon Health & Science University; Oregon Health & Science University; Oregon National Primate Research Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Alphabet Inc.; Google Incorporated; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Jackson Laboratory; University of California System; University of California Santa Barbara; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Arizona State University; Arizona State University-Tempe; University of California System; University of California Berkeley; HSE University (National Research University Higher School of Economics); Zoological Society of San Diego; Tel Aviv University; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
摘要：Apes possess two sex chromosomes-the male-specific Y chromosome and the X chromosome, which is present in both males and females. The Y chromosome is crucial for male reproduction, with deletions being linked to infertility 1 . The X chromosome is vital for reproduction and cognition 2 . Variation in mating patterns and brain function among apes suggests corresponding differences in their sex chromosomes. However, owing to their repetitive nature and incomplete reference assemblies, ape sex ch...
