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作者:Muenzner, Julia; Trebulle, Pauline; Agostini, Federica; Zauber, Henrik; Messner, Christoph B.; Steger, Martin; Kilian, Christiane; Lau, Kate; Barthel, Natalie; Lehmann, Andrea; Textoris-Taube, Kathrin; Caudal, Elodie; Egger, Anna-Sophia; Amari, Fatma; De Chiara, Matteo; Demichev, Vadim; Gossmann, Toni I.; Muelleder, Michael; Liti, Gianni; Schacherer, Joseph; Selbach, Matthias; Berman, Judith; Ralser, Markus
作者单位:Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Francis Crick Institute; University of Oxford; Wellcome Centre for Human Genetics; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Swiss Institute of Allergy & Asthma Research; University of Zurich; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Dortmund University of Technology; Institut Universitaire de France; Tel Aviv University; Max Planck Society
摘要:Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions and allows the generalizability of laboratory findings to be assessed. One notable discovery made in natural isolates of Saccharomyces cerevisiae is that aneuploidy-an imbalance in chromosome copy numbers-is frequent(1,2) (around 20%), which seems to contradict the substantial fitness costs and transient nature of aneuploidy when it is engineered in the laboratory(3-5). Here we generate a...
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作者:Garimella, Kiran; Chauchard, Simon
作者单位:Rutgers University System; Rutgers University New Brunswick; Universidad Carlos III de Madrid
摘要:A sample of roughly two million WhatsApp messages highlights urgent concerns about the spread and prevalence of AI-generated political content generated by artificial intelligence.
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作者:[Anonymous]
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作者:Heilig, Markus; Petrella, Michele
作者单位:Linkoping University
摘要:Neuroscientists find that two distinct neural pathways are responsible for the addictive properties of the opioid fentanyl: one mediates reward, the other promotes the seeking of relief from symptoms of withdrawal.
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作者:Callaway, Ewen
摘要:Researchers are aiming to create fully accessible versions of the latest iteration of DeepMind's blockbuster protein-structure model.
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作者:Peplow, Mark
摘要:Chemists achieve synthetic feat with radioactive promethium for the first time.
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作者:von Kuegelgen, Andriko; Cassidy, C. Keith; van Dorst, Sofie; Pagani, Lennart L.; Batters, Christopher; Ford, Zephyr; Loewe, Jan; Alva, Vikram; Stansfeld, Phillip J.; Bharat, Tanmay A. M.
作者单位:MRC Laboratory Molecular Biology; University of Oxford; University of Missouri System; University of Missouri Columbia; MRC Laboratory Molecular Biology; University of Warwick
摘要:Nitrosopumilus maritimus is an ammonia-oxidizing archaeon that is crucial to the global nitrogen cycle(1,2). A critical step for nitrogen oxidation is the entrapment of ammonium ions from a dilute marine environment at the cell surface and their subsequent channelling to the cell membrane of N. maritimus. Here we elucidate the structure of the molecular machinery responsible for this process, comprising the surface layer (S-layer), using electron cryotomography and subtomogram averaging from c...
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作者:Bucar, Dejan-Kresimir
作者单位:University of London; University College London
摘要:A simple design approach and predictive computational methods have spawned a pathway for making materials that could trap specific molecules - an ability needed for applications such as carbon capture.
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作者:Ecker, Ullrich; Roozenbeek, Jon; van der Linden, Sander; Tay, Li Qian; Cook, John; Oreskes, Naomi; Lewandowsky, Stephan
作者单位:University of Western Australia; University of London; King's College London; University of Cambridge; Australian National University; University of Melbourne; University of Bristol
摘要:In today's polarized political climate, researchers who combat mistruths have come under attack and been labelled as unelected arbiters of truth. But the fight against misinformation is valid, warranted and urgently required.
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作者:Savage, Neil
摘要:Although researchers often face uncertainty when grants expire with no replacement in sight, there are creative ways to ease the dry spell.