8015期

最新文章

• Natural proteome diversity links aneuploidy tolerance to protein turnover AI翻译
  作者：Muenzner, Julia; Trebulle, Pauline; Agostini, Federica; Zauber, Henrik; Messner, Christoph B.; Steger, Martin; Kilian, Christiane; Lau, Kate; Barthel, Natalie; Lehmann, Andrea; Textoris-Taube, Kathrin; Caudal, Elodie; Egger, Anna-Sophia; Amari, Fatma; De Chiara, Matteo; Demichev, Vadim; Gossmann, Toni I.; Muelleder, Michael; Liti, Gianni; Schacherer, Joseph; Selbach, Matthias; Berman, Judith; Ralser, Markus
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Francis Crick Institute; University of Oxford; Wellcome Centre for Human Genetics; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Swiss Institute of Allergy & Asthma Research; University of Zurich; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Dortmund University of Technology; Institut Universitaire de France; Tel Aviv University; Max Planck Society
  摘要：Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions and allows the generalizability of laboratory findings to be assessed. One notable discovery made in natural isolates of Saccharomyces cerevisiae is that aneuploidy-an imbalance in chromosome copy numbers-is frequent(1,2) (around 20%), which seems to contradict the substantial fitness costs and transient nature of aneuploidy when it is engineered in the laboratory(3-5). Here we generate a...
• How prevalent is AI misinformation? What our studies in India show so far AI翻译
  作者：Garimella, Kiran; Chauchard, Simon
  作者单位：Rutgers University System; Rutgers University New Brunswick; Universidad Carlos III de Madrid
  摘要：A sample of roughly two million WhatsApp messages highlights urgent concerns about the spread and prevalence of AI-generated political content generated by artificial intelligence.
• GUT REACTION: HOW SEX HORMONES GET PREGNANCY BOOST AI翻译
  作者：[Anonymous]
• Neural pathways for reward and relief promote fentanyl addiction AI翻译
  作者：Heilig, Markus; Petrella, Michele
  作者单位：Linkoping University
  摘要：Neuroscientists find that two distinct neural pathways are responsible for the addictive properties of the opioid fentanyl: one mediates reward, the other promotes the seeking of relief from symptoms of withdrawal.
• Who will make AlphaFold3 open source? AI翻译
  作者：Callaway, Ewen
  摘要：Researchers are aiming to create fully accessible versions of the latest iteration of DeepMind's blockbuster protein-structure model.
• Element from the periodic table's far reaches coaxed into elusive compound AI翻译
  作者：Peplow, Mark
  摘要：Chemists achieve synthetic feat with radioactive promethium for the first time.
• Membraneless channels sieve cations in ammonia-oxidizing marine archaea AI翻译
  作者：von Kuegelgen, Andriko; Cassidy, C. Keith; van Dorst, Sofie; Pagani, Lennart L.; Batters, Christopher; Ford, Zephyr; Loewe, Jan; Alva, Vikram; Stansfeld, Phillip J.; Bharat, Tanmay A. M.
  作者单位：MRC Laboratory Molecular Biology; University of Oxford; University of Missouri System; University of Missouri Columbia; MRC Laboratory Molecular Biology; University of Warwick
  摘要：Nitrosopumilus maritimus is an ammonia-oxidizing archaeon that is crucial to the global nitrogen cycle(1,2). A critical step for nitrogen oxidation is the entrapment of ammonium ions from a dilute marine environment at the cell surface and their subsequent channelling to the cell membrane of N. maritimus. Here we elucidate the structure of the molecular machinery responsible for this process, comprising the surface layer (S-layer), using electron cryotomography and subtomogram averaging from c...
• Designer porous solids open up vast sandbox for materials research AI翻译
  作者：Bucar, Dejan-Kresimir
  作者单位：University of London; University College London
  摘要：A simple design approach and predictive computational methods have spawned a pathway for making materials that could trap specific molecules - an ability needed for applications such as carbon capture.
• Misinformation poses a bigger threat to democracy than you might think AI翻译
  作者：Ecker, Ullrich; Roozenbeek, Jon; van der Linden, Sander; Tay, Li Qian; Cook, John; Oreskes, Naomi; Lewandowsky, Stephan
  作者单位：University of Western Australia; University of London; King's College London; University of Cambridge; Australian National University; University of Melbourne; University of Bristol
  摘要：In today's polarized political climate, researchers who combat mistruths have come under attack and been labelled as unelected arbiters of truth. But the fight against misinformation is valid, warranted and urgently required.
• What steps to take when funding starts to run out AI翻译
  作者：Savage, Neil
  摘要：Although researchers often face uncertainty when grants expire with no replacement in sight, there are creative ways to ease the dry spell.