作者：Chan, Adelyne S. L.; Zhu, Haoran; Narita, Masako; Cassidy, Liam D.; Young, Andrew R. J.; Bermejo-Rodriguez, Camino; Janowska, Aleksandra T.; Chen, Hung-Chang; Gough, Sarah; Oshimori, Naoki; Zender, Lars; Aitken, Sarah J.; Hoare, Matthew; Narita, Masashi
作者单位：CRUK Cambridge Institute; University of Cambridge; Cancer Research UK; University of Liverpool; Oregon Health & Science University; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Helmholtz Association; German Cancer Research Center (DKFZ); Eberhard Karls University of Tubingen; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; Institute of Science Tokyo; Tokyo Institute of Technology
摘要：Oncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor mechanism associated with premalignancy1,2. Achieving this phenotype typically requires a high level of oncogenic stress, yet the phenotype provoked by lower oncogenic dosage remains unclear. Here we develop oncogenic RAS dose-escalation models in vitro and in vivo, revealing a RAS dose-driven non-linear continuum of downstream phenotypes. In a hepatocyte OIS model in vivo, ectopic expression of NRAS(G12V) does not induc...
作者：Lalli, Roberto; Navarro, Jaume
作者单位：Polytechnic University of Turin; University of Basque Country
摘要：Can science be a route to peace and common understanding? A glance at the history of one institution shows: only when scientists actively commit to it.
作者：Laxminarayan, Ramanan
摘要：Ensuring that clinics in low- and middle-income countries are well-stocked with high-quality antibiotics could help physicians to treat millions of people each year and slow the spread of drug resistance.
作者：Guterres-Pazin, Michelle Gil
作者：Mckendry, Rachel A.; Rogers, Elliott; Singer, Mervyn; Brown, Colin S.
作者单位：University of London; University College London; UK Health Security Agency (UKHSA)
作者：Nowogrodzki, Julian
摘要：The first face transplant to also include an eyeball was a surgical coup - but restoring vision remains a challenge.
