-
作者：Shah, Hiral; Olivetta, Marine; Bhickta, Chandni; Ronchi, Paolo; Trupinic, Monika; Tromer, Eelco C.; Tolic, Iva M.; Schwab, Yannick; Dudin, Omaya; Dey, Gautam
-
作者：Shah, Hiral; Olivetta, Marine; Bhickta, Chandni; Ronchi, Paolo; Trupinic, Monika; Tromer, Eelco C.; Tolic, Iva M.; Schwab, Yannick; Dudin, Omaya; Dey, Gautam
作者单位：European Molecular Biology Laboratory (EMBL); Swiss Institute Experimental Cancer Research; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; European Molecular Biology Laboratory (EMBL); University of Groningen
-
作者：Green, Gilad Sahar; Fujita, Masashi; Yang, Hyun-Sik; Taga, Mariko; Cain, Anael; McCcabe, Cristin; Comandante-Lou, Natacha; White, Charles C.; Schmidtner, Anna K.; Zeng, Lu; Sigalov, Alina; Wang, Yangling; Regev, Aviv; Klein, Hans-Ulrich; Menon, Vilas; Bennett, David A.; Habib, Naomi; De Jager, Philip L.
作者单位：Hebrew University of Jerusalem; NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Rush University; Massachusetts Institute of Technology (MIT); Roche Holding; Genentech; Roche Holding USA
摘要：Alzheimer's disease (AD) has recently been associated with diverse cell states1-11, yet when and how these states affect the onset of AD remains unclear. Here we used a data-driven approach to reconstruct the dynamics of the brain's cellular environment and identified a trajectory leading to AD that is distinct from other ageing-related effects. First, we built a comprehensive cell atlas of the aged prefrontal cortex from 1.65 million single-nucleus RNA-sequencing profiles sampled from 437 old...
-
作者：Stankovic, Stasa; Shekari, Saleh; Huang, Qin Qin; Gardner, Eugene J.; Ivarsdottir, Erna V.; Owens, Nick D. L.; Mavaddat, Nasim; Azad, Ajuna; Hawkes, Gareth; Kentistou, Katherine A.; Beaumont, Robin N.; Day, Felix R.; Zhao, Yajie; Jonsson, Hakon; Rafnar, Thorunn; Tragante, Vinicius; Sveinbjornsson, Gardar; Oddsson, Asmundur; Styrkarsdottir, Unnur; Gudmundsson, Julius; Stacey, Simon N.; Gudbjartsson, Daniel F.; Kennedy, Kitale; Wood, Andrew R.; Weedon, Michael N.; Ong, Ken K.; Wright, Caroline F.; Hoffmann, Eva R.; Sulem, Patrick; Hurles, Matthew E.; Ruth, Katherine S.; Martin, Hilary C.; Stefansson, Kari; Perry, John R. B.; Murray, Anna
作者单位：University of Cambridge; University of Exeter; University of Queensland; Wellcome Trust Sanger Institute; Decode Genetics; University of Cambridge; University of Copenhagen; University of Cambridge; University of Cambridge
摘要：Human genetic studies of common variants have provided substantial insight into the biological mechanisms that govern ovarian ageing1. Here we report analyses of rare protein-coding variants in 106,973 women from the UK Biobank study, implicating genes with effects around five times larger than previously found for common variants (ETAA1, ZNF518A, PNPLA8, PALB2 and SAMHD1). The SAMHD1 association reinforces the link between ovarian ageing and cancer susceptibility1, with damaging germline vari...
-
作者：Lynch, Charles J.; Elbau, Immanuel G.; Ng, Tommy; Ayaz, Aliza; Zhu, Shasha; Wolk, Danielle; Manfredi, Nicola; Johnson, Megan; Chang, Megan; Chou, Jolin; Summerville, Indira; Ho, Claire; Lueckel, Maximilian; Bukhari, Hussain; Buchanan, Derrick; Victoria, Lindsay W.; Solomonov, Nili; Goldwaser, Eric; Moia, Stefano; Caballero-Gaudes, Cesar; Downar, Jonathan; Vila-Rodriguez, Fidel; Daskalakis, Zafiris J.; Blumberger, Daniel M.; Kay, Kendrick; Aloysi, Amy; Gordon, Evan M.; Bhati, Mahendra T.; Williams, Nolan; Power, Jonathan D.; Zebley, Benjamin; Grosenick, Logan; Gunning, Faith M.; Liston, Conor
作者单位：Cornell University; Weill Cornell Medicine; Johannes Gutenberg University of Mainz; Stanford University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Geneva; University of Toronto; University of Toronto; University of British Columbia; University of California System; University of California San Diego; University of Toronto; Centre for Addiction & Mental Health - Canada; University of Minnesota System; University of Minnesota Twin Cities; Icahn School of Medicine at Mount Sinai; Washington University (WUSTL)
摘要：Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset1. Furthermore, whereas depression is episodic, few longitudinal neuroimaging studies exist, limiting understanding of mechanisms that drive mood-state transitions. The emerging field of precision functional mapping has used densely sampled longitudinal neuroimaging data to show behaviourally meani...
-
作者：Lee, Casey S.; Chen, Sisi; Berry, Corbett T.; Kelly, Andre R.; Herman, Patrick J.; Oh, Sangwook; O'Connor, Roddy S.; Payne, Aimee S.; Ellebrecht, Christoph T.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Hallym University; Columbia University
摘要：Early expansion and long-term persistence predict efficacy of chimeric antigen receptor T cells (CARTs)1-7, but mechanisms governing effector versus memory CART differentiation and whether asymmetric cell division induces differential fates in human CARTs remain unclear. Here we show that target-induced proximity labelling enables isolation of first-division proximal-daughter and distal-daughter CD8 CARTs that asymmetrically distribute their surface proteome and transcriptome, resulting in div...
-
作者：Burnett Jr, John C.
作者单位：Mayo Clinic; Mayo Clinic
-
作者：Petrova, Irina Y.; Miralles, Diego G.; Brient, Florent; Donat, Markus G.; Min, Seung-Ki; Kim, Yeon-Hee; Bador, Margot
作者单位：Ghent University; Institut Polytechnique de Paris; Ecole des Ponts ParisTech; Ecole Polytechnique; Universite Paris Cite; Sorbonne Universite; Universitat Politecnica de Catalunya; Barcelona Supercomputer Center (BSC-CNS); ICREA; Pohang University of Science & Technology (POSTECH); Yonsei University; CERFACS; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse
摘要：Climate models indicate that dry extremes will be exacerbated in many regions of the world1,2. However, confidence in the magnitude and timing of these projected changes remains low3,4, leaving societies largely unprepared5,6. Here we show that constraining model projections with observations using a newly proposed emergent constraint (EC) reduces the uncertainty in predictions of a core drought indicator, the longest annual dry spell (LAD), by 10-26% globally. Our EC-corrected projections rev...
-
作者：Saha, Senjuti; Gales, Ana Cristina; Okeke, Iruka N.; Shamas, Nour
作者单位：Universidade Federal de Sao Paulo (UNIFESP); University of Ibadan
摘要：Ahead of a United Nations meeting on the global challenge of drug-resistant infections, Nature asked health-care experts in emerging economies to describe what would address the issue in their country or region most effectively. Ahead of a United Nations meeting on the global challenge of drug-resistant infections, Nature asked health-care experts in emerging economies to describe what would address the issue in their country or region most effectively.
-
作者：Nomburg, Jason; Doherty, Erin E.; Price, Nathan; Bellieny-Rabelo, Daniel; Zhu, Yong K.; Doudna, Jennifer A.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley
摘要：The rapid evolution of viruses generates proteins that are essential for infectivity and replication but with unknown functions, due to extreme sequence divergence1. Here, using a database of 67,715 newly predicted protein structures from 4,463 eukaryotic viral species, we found that 62% of viral proteins are structurally distinct and lack homologues in the AlphaFold database2,3. Among the remaining 38% of viral proteins, many have non-viral structural analogues that revealed surprising simila...
