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作者:Chanin, Rachael B.; West, Patrick T.; Wirbel, Jakob; Gill, Matthew O.; Green, Gabriella Z. M.; Park, Ryan M.; Enright, Nora; Miklos, Arjun M.; Hickey, Angela S.; Brooks, Erin F.; Lum, Krystal K.; Cristea, Ileana M.; Bhatt, Ami S.
作者单位:Stanford University; Stanford University; Stanford University; Princeton University
摘要:Bacterial populations that originate from a single bacterium are not strictly clonal and often contain subgroups with distinct phenotypes(1). Bacteria can generate heterogeneity through phase variation-a preprogrammed, reversible mechanism that alters gene expression levels across a population(1). One well-studied type of phase variation involves enzyme-mediated inversion of specific regions of genomic DNA2. Frequently, these DNA inversions flip the orientation of promoters, turning transcript...
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作者:Nazarovets, Serhii
作者单位:Ministry of Education & Science of Ukraine; Borys Grinchenko Kyiv Metropolitan University
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作者:Schlegel, Philipp; Yin, Yijie; Bates, Alexander S.; Dorkenwald, Sven; Eichler, Katharina; Brooks, Paul; Han, Daniel S.; Gkantia, Marina; dos Santos, Marcia; Munnelly, Eva J.; Badalamente, Griffin; Capdevila, Laia Serratosa; Sane, Varun A.; Fragniere, Alexandra M. C.; Kiassat, Ladann; Pleijzier, Markus W.; Sturner, Tomke; Tamimi, Imaan F. M.; Dunne, Christopher R.; Salgarella, Irene; Javier, Alexandre; Fang, Siqi; Perlman, Eric; Kazimiers, Tom; Jagannathan, Sridhar R.; Matsliah, Arie; Sterling, Amy R.; Yu, Szi-chieh; McKellar, Claire E.; Costa, Marta; Seung, H. Sebastian; Murthy, Mala; Hartenstein, Volker; Bock, Davi D.; Jefferis, Gregory S. X. E.
作者单位:MRC Laboratory Molecular Biology; University of Cambridge; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard Medical School; University of Oxford; Princeton University; Princeton University; University of New South Wales Sydney; University of California System; University of California Los Angeles; University of Vermont
摘要:The fruit fly Drosophila melanogaster has emerged as a key model organism in neuroscience, in large part due to the concentration of collaboratively generated molecular, genetic and digital resources available for it. Here we complement the approximately 140,000 neuron FlyWire whole-brain connectome(1) with a systematic and hierarchical annotation of neuronal classes, cell types and developmental units (hemilineages). Of 8,453 annotated cell types, 3,643 were previously proposed in the partial...
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作者:Kuglitsch, Monique M.; Cox, Jon; Luterbacher, Jurg; Jamoussi, Bilel; Xoplaki, Elena; Thummarukudy, Muralee; Radwan, Golestan Sally; Yasukawa, Soichiro; McClain, Shanna N.; Albayrak, Rustem Arif; Oehmen, David; Ward, Thomas
作者单位:Fraunhofer Gesellschaft; Fraunhofer Germany; Fraunhofer Telecommunications Heinrich Hertz Institut; Justus Liebig University Giessen; Justus Liebig University Giessen; Justus Liebig University Giessen; United Nations Environment Programme; National Aeronautics & Space Administration (NASA); University System of Maryland; University of Maryland Baltimore County; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; International Business Machines (IBM); IBM USA
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作者:[Anonymous]
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作者:Van Damme, J.; Massar, S.; Acharya, R.; Ivanov, Ts.; Lozano, D. Perez; Canvel, Y.; Demarets, M.; Vangoidsenhoven, D.; Hermans, Y.; Lai, J. G.; Vadiraj, A. M.; Mongillo, M.; Wan, D.; De Boeck, J.; Potocnik, A.; De Greve, K.
作者单位:Interuniversity Microelectronics Centre; KU Leuven
摘要:The development of superconducting qubit technology has shown great potential for the construction of practical quantum computers1,2. As the complexity of quantum processors continues to grow, the need for stringent fabrication tolerances becomes increasingly critical3. Utilizing advanced industrial fabrication processes could facilitate the necessary level of fabrication control to support the continued scaling of quantum processors. However, at present, these industrial processes are not opt...
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作者:Seung, H. Sebastian
作者单位:Princeton University; Princeton University
摘要:As connectomics advances, it will become commonplace to know far more about the structure of a nervous system than about its function. The starting point for many investigations will become neuronal wiring diagrams, which will be interpreted to make theoretical predictions about function. Here I demonstrate this emerging approach with the Drosophila optic lobe, analysing its structure to predict that three Dm3 (refs. 1-4) and three TmY (refs. 2,4) cell types are part of a circuit that serves t...
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作者:Devineni, Anita V.
作者单位:Emory University
摘要:Neuroscientists have reconstructed the first complete wiring map of the fruit-fly brain, including 140,000 neurons and more than 50 million connections. This resource has already begun to revolutionize the field.
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作者:Remmel, Ariana
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作者:Lambert, Fabrice
作者单位:Pontificia Universidad Catolica de Chile