作者：Cao, Dominica; Bergmann, Jenna; Zhong, Liangwen; Hemalatha, Anupama; Dingare, Chaitanya; Jensen, Tyler; Cox, Andy L.; Greco, Valentina; Steventon, Benjamin; Sozen, Berna
作者单位：Yale University; University of Cambridge; Yale University; Yale University; Yale University; Howard Hughes Medical Institute; Yale University
摘要：The prevailing dogma for morphological patterning in developing organisms argues that the combined inputs of transcription factor networks and signalling morphogens alone generate spatially and temporally distinct expression patterns. However, metabolism has also emerged as a critical developmental regulator1-10, independent of its functions in energy production and growth. The mechanistic role of nutrient utilization in instructing cellular programmes to shape the in vivo developing mammalian...
作者：Taddeo, Mariarosaria; Blanchard, Alexander; Pundyk, Kate
作者单位：University of Oxford; Alan Turing Institute; University of Oxford
作者：[Anonymous]
摘要：Scientists are closing in on a tool that can reliably identify AI-generated text without affecting the user's experience. But the technology's robustness remains a challenge.
作者：Luo, Zhe-Xi
作者单位：University of Chicago
摘要：Mammals feed using a jaw hinge formed by dentary and squamosal bones. Fossil evidence reveals that this type of joint evolved independently in an extinct species of mammalian relatives called cynodonts.
作者：[Anonymous]
摘要：Modelling of an outbreak at a US university suggests that a nimble vaccination campaign can limit transmission.
作者：Chowdhury, Rumman; Forsberg, Ole J.; Tay, Li Qian; Kasenally, Roukaya; King, Bridgett A.
作者单位：Australian National University; University of Mauritius; University of Kentucky
摘要：Five specialists share essential books for understanding threats to democracy past and present, and finding ways to guard against them.
作者：Lavillegrand, Jean-Remi; Al-Rifai, Rida; Thietart, Sara; Guyon, Theo; Vandestienne, Marie; Cohen, Raphael; Duval, Vincent; Zhong, Xiaodan; Yen, Daniel; Ozturk, Mumin; Negishi, Yutaka; Konkel, Joanne; Pinteaux, Emmanuel; Lenoir, Olivia; Vilar, Jose; Laurans, Ludivine; Esposito, Bruno; Bredon, Marius; Sokol, Harry; Diedisheim, Marc; Saliba, Antoine-Emmanuel; Zernecke, Alma; Cochain, Clement; Haub, Jessica; Tedgui, Alain; Speck, Nancy A.; Taleb, Soraya; Mhlanga, Musa M.; Schlitzer, Andreas; Riksen, Niels P.; Ait-Oufella, Hafid
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; University of Bonn; University of Pennsylvania; University of Pennsylvania; Radboud University Nijmegen; University of Manchester; University of Manchester; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); AgroParisTech; Universite Paris Saclay; INRAE; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Helmholtz Association; Helmholtz-Center for Infection Research; University of Wurzburg; Radboud University Nijmegen; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP
摘要：Systemic immune responses caused by chronic hypercholesterolaemia contribute to atherosclerosis initiation, progression and complications1. However, individuals often change their dietary habits over time2, and the effects of an alternating high-fat diet (HFD) on atherosclerosis remain unclear. Here, to address this relevant issue, we developed a protocol using atherosclerosis-prone mice to compare an alternating versus continuous HFD while maintaining similar overall exposure periods. We foun...
