作者：Ardanaz, Carlos G.; Steculorum, Sophie M.
摘要：The discovery of a pathway that controls appetite and calorie burning has led to the development of a drug that modulates both by targeting one receptor, offering a promising strategy for weight loss and improved metabolic health.
作者：Jones, Gavin M.
作者单位：United States Department of Agriculture (USDA); United States Forest Service
作者：Turner, Adrianna M.; Li, Lucy; Monk, Ian R.; Lee, Jean Y. H.; Ingle, Danielle J.; Portelli, Stephanie; Sherry, Norelle L.; Isles, Nicole; Seemann, Torsten; Sharkey, Liam K.; Walsh, Calum J.; Reid, Gavin E.; Nie, Shuai; Eijkelkamp, Bart A.; Holmes, Natasha E.; Collis, Brennan; Vogrin, Sara; Hiergeist, Andreas; Weber, Daniela; Gessner, Andre; Holler, Ernst; Ascher, David B.; Duchene, Sebastian; Scott, Nichollas E.; Stinear, Timothy P.; Kwong, Jason C.; Gorrie, Claire L.; Howden, Benjamin P.; Carter, Glen P.
作者单位：University of Melbourne; Peter Doherty Institute; Monash Health; University of Queensland; University of Melbourne; Peter Doherty Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; University of Melbourne; University of Melbourne; University of Melbourne; University of Melbourne; Flinders University South Australia; University of Melbourne; Peter Doherty Institute; University of Melbourne; University of Regensburg; University of Regensburg; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
摘要：Multidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health1. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action2, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients with liver disease3, causes cross-resistance to daptomycin in VREfm. Amino acid ch...
作者：Aczel, Balazs
作者单位：Eotvos Lorand University
摘要：Open-ended research is essential to building solid hypotheses in the social sciences - without it, even the best-planned analyses can fail.
作者：Bian, Yangyang; Yan, Xiaohan; Chen, Fei; Li, Qian; Li, Bo; Hou, Wenjun; Lu, Zizhe; Wang, Shuaibing; Zhang, Han; Zhang, Wenjing; Zhang, Dandan; Tang, Aiwei; Fan, Fengjia; Shen, Huaibin
作者单位：Henan University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Beijing Jiaotong University; TCL Inc.
摘要：Green indium phosphide (InP)-based quantum dot light-emitting diodes (QD-LEDs) still suffer from low efficiency and short operational lifetime, posing a critical challenge to fully cadmium-free QD-LED displays and lighting1-3. Unfortunately, the factors that underlie these limitations remain unclear and, therefore, no clear device-engineering guidelines are available. Here, by using electrically excited transient absorption spectroscopy, we find that the low efficiency of state-of-the-art gree...
作者：Kozlov, Max
摘要：Sweeping changes and more research scrutiny could be on the way for the US National Institutes of Health.
作者：Kwon, Diana
摘要：Half a dozen drugs are in trials for conditions of the brain, but success is not guaranteed.
