2024

最新文章

• Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice AI翻译
  作者：Wang, Gang; Chen, Xi; Yu, Chengzhi; Shi, Xiaobao; Lan, Wenxian; Gao, Chaofeng; Yang, Jun; Dai, Huiling; Zhang, Xiaowei; Zhang, Huili; Zhao, Boyu; Xie, Qi; Yu, Nan; He, Zuhua; Zhang, Yu; Wang, Ertao
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fujian Agriculture & Forestry University; Shanghai Normal University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; ShanghaiTech University
  摘要：Plant pattern-recognition receptors perceive microorganism-associated molecular patterns to activate immune signalling(1,2). Activation of the pattern-recognition receptor kinase CERK1 is essential for immunity, but tight inhibition of receptor kinases in the absence of pathogen is crucial to prevent autoimmunity(3,4). Here we find that the U-box ubiquitin E3 ligase OsCIE1 acts as a molecular brake to inhibit OsCERK1 in rice. During homeostasis, OsCIE1 ubiquitinates OsCERK1, reducing its kinas...
• Changemaker: Freeman Hrabowski AI翻译
  作者：Gewin, Virginia; Hrabowski, Freeman
• Quantum tunnelling of electrons brings ultrafast optical microscopy to the atomic scale AI翻译
  作者：Siday, Thomas; Huber, Rupert
  作者单位：University of Regensburg
  摘要：The oscillating electromagnetic fields that carry light can cause electrons to tunnel back and forth through a potential energy barrier. Remarkably, this alternating current can coherently emit measurable light waves - an unexpected process that can be exploited to build an optical microscope that undercuts existing spatial and temporal limitations.
• AI's English-language bias is cultural bias, too AI翻译
  作者：Luo, Queenie; Puett, Michael
  作者单位：Harvard University
• Why snow is crucial for water supply AI翻译
  作者：Ryberg, Karen R.
• Adrenal cells provide clues to a parental-care puzzle AI翻译
  作者：Tollkuhn, Jessica
  作者单位：Cold Spring Harbor Laboratory
  摘要：Both parents of oldfield mice care for offspring, whereas in deer mice, mothers usually care for pups. The discovery of a type of adrenal-gland cell that is present in oldfield mice but not in deer mice helps to explain the difference.
• Genome organization around nuclear speckles drives mRNA splicing efficiency AI翻译
  作者：Bhat, Prashant; Chow, Amy; Emert, Benjamin; Ettlin, Olivia; Quinodoz, Sofia A.; Strehle, Mackenzie; Takei, Yodai; Burr, Alex; Goronzy, Isabel N.; Chen, Allen W.; Huang, Wesley; Ferrer, Jose Lorenzo M.; Soehalim, Elizabeth; Goh, Say-Tar; Chari, Tara; Sullivan, Delaney K.; Blanco, Mario R.; Guttman, Mitchell
  作者单位：California Institute of Technology; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Princeton University
  摘要：The nucleus is highly organized, such that factors involved in the transcription and processing of distinct classes of RNA are confined within specific nuclear bodies1,2. One example is the nuclear speckle, which is defined by high concentrations of protein and noncoding RNA regulators of pre-mRNA splicing3. What functional role, if any, speckles might play in the process of mRNA splicing is unclear4,5. Here we show that genes localized near nuclear speckles display higher spliceosome concentr...
• Heed lessons from past studies involving transgender people: first, do no harm AI翻译
  作者：Kennis, Mathilde; Staicu, Robin; Dewitte, Marieke; T'Sjoen, Guy; Sack, Alexander T.; Duecker, Felix
  作者单位：Maastricht University; Maastricht University; Maastricht University; Ghent University; Ghent University Hospital; Ghent University; Ghent University Hospital; Maastricht University
  摘要：Decades of neuroscientific work have focused on exploring a biological basis for transgender identity - but researchers must take societal factors into account.
• Mapping model units to visual neurons reveals population code for social behaviour AI翻译
  作者：Cowley, Benjamin R.; Calhoun, Adam J.; Rangarajan, Nivedita; Ireland, Elise; Turner, Maxwell H.; Pillow, Jonathan W.; Murthy, Mala
  作者单位：Princeton University; Cold Spring Harbor Laboratory; Stanford University
  摘要：The rich variety of behaviours observed in animals arises through the interplay between sensory processing and motor control. To understand these sensorimotor transformations, it is useful to build models that predict not only neural responses to sensory input(1-5) but also how each neuron causally contributes to behaviour(6,7). Here we demonstrate a novel modelling approach to identify a one-to-one mapping between internal units in a deep neural network and real neurons by predicting the beha...
• Joint recycling of steel and cement cuts CO2 emissions AI翻译
  作者：Miller, Sabbie A.
  作者单位：University of California System; University of California Davis
  摘要：Cement can be reused by including it as a component of steel recycling. This opens the way to an industrial partnership that improves the use of materials and lowers carbon emissions - but only if waste resources are well managed.