作者：Levison, Harold F.; Marchi, Simone; Noll, Keith S.; Spencer, John R.; Statler, Thomas S.; Bell, James F.; Bierhaus, Edward B.; Binzel, Richard; Bottke, William F.; Britt, Daniel; Brown, Michael E.; Buie, Marc W.; Christensen, Philip R.; Dello Russo, Neil; Emery, Joshua P.; Grundy, William M.; Hahn, Matthias; Hamilton, Victoria E.; Howett, Carly; Kaplan, Hannah; Kretke, Katherine; Lauer, Tod R.; Manzoni, Claudia; Marschall, Raphael; Martin, Audrey C.; May, Brian H.; Mottola, Stefano; Olkin, Catherine B.; Paetzold, Martin; Parker, Joel Wm.; Porter, Simon; Preusker, Frank; Protopapa, Silvia; Reuter, Dennis C.; Robbins, Stuart J.; Salmon, Julien; Simon, Amy A.; Stern, S. Alan; Sunshine, Jessica M.; Wong, Ian; Weaver, Harold A.; Adam, Coralie; Ancheta, Shanti; Andrews, John; Anwar, Saadat; Barnouin, Olivier S.; Beasley, Matthew; Berry, Kevin E.; Birath, Emma; Bolin, Bryce; Booco, Mark; Burns, Rich; Campbell, Pam; Carpenter, Russell; Crombie, Katherine; Effertz, Mark; Eifert, Emily; Ellis, Caroline; Faiks, Preston; Fischetti, Joel; Fleming, Paul; Francis, Kristen; Franco, Ray; Freund, Sandy; Gallagher, Claire; Geeraert, Jeroen; Gobat, Caden; Gorgas, Donovan; Granat, Chris; Gray, Sheila; Haas, Patrick; Harch, Ann; Hegedus, Katie; Isabelle, Chris; Jackson, Bill; Jacob, Taylor; Jennings, Sherry; Kaufmann, David; Keeney, Brian A.; Kennedy, Thomas; Lauffer, Karl; Lessac-Chenen, Erik; Leonard, Rob; Levine, Andrew; Lunsford, Allen; Martin, Tim; Mcadams, Jim; Mehall, Greg; Merkley, Trevor; Miller, Graham; Montanaro, Matthew; Montgomery, Anna; Murphy, Graham; Myers, Maxwell; Nelson, Derek S.; Ocampo, Adriana; Olds, Ryan; Pelgrift, John Y.; Perkins, Trevor; Pineau, Jon; Poland, Devin; Ramanan, Vaishnavi; Rose, Debi; Sahr, Eric; Short, Owen; Solanki, Ishita; Stanbridge, Dale; Sutter, Brian; Talpas, Zachary; Taylor, Howard; Treiu, Bo; Vermeer, Nate; Vincent, Michael; Wallace, Mike; Weigle, Gerald; Wibben, Daniel R.; Wiens, Zach; Wilson, John P.; Zhao, Yifan
作者单位：Southwest Research Institute; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); Mary W. Jackson NASA Headquarters; Arizona State University; Arizona State University-Tempe; Massachusetts Institute of Technology (MIT); State University System of Florida; University of Central Florida; California Institute of Technology; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; Northern Arizona University; University of Cologne; University of Oxford; Universite Cote d'Azur; Observatoire de la Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Helmholtz Association; German Aerospace Centre (DLR); University System of Maryland; University of Maryland College Park; American University; Cornell University; Rochester Institute of Technology
摘要：Asteroids with diameters less than about 5 km have complex histories because they are small enough for radiative torques (that is, YORP, short for the Yarkovsky-O'Keefe-Radzievskii-Paddack effect) 1 to be a notable factor in their evolution 2 . (152830) Dinkinesh is a small asteroid orbiting the Sun near the inner edge of the main asteroid belt with a heliocentric semimajor axis of 2.19 au; its S-type spectrum 3,4 is typical of bodies in this part of the main belt 5 . Here we report observatio...
作者：Papasergi-Scott, Makaia M.; Perez-Hernandez, Guillermo; Batebi, Hossein; Gao, Yang; Eskici, Goezde; Seven, Alpay B.; Panova, Ouliana; Hilger, Daniel; Casiraghi, Marina; He, Feng; Maul, Luis; Gmeiner, Peter; Kobilka, Brian K.; Hildebrand, Peter W.; Skiniotis, Georgios
作者单位：Stanford University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Leipzig University; Philipps University Marburg; University of Milan; University of Erlangen Nuremberg; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Stanford University
摘要：G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating guanine nucleotide exchange in the G alpha subunit1. To visualize this mechanism, we developed a time-resolved cryo-EM approach that examines the progression of ensembles of pre-steady-state intermediates of a GPCR-G-protein complex. By monitoring the transitions of the stimulatory Gs protein in complex with the beta 2-adrenergic receptor at short sequential time points after GTP addition, we identified the c...
