作者：Visscher, Peter M.; Gyngell, Christopher; Yengo, Loic; Savulescu, Julian
作者单位：University of Queensland; University of Oxford; Murdoch Children's Research Institute; University of Melbourne; University of Oxford; National University of Singapore
摘要：Polygenic genome editing in human embryos and germ cells is predicted to become feasible in the next three decades. Several recent books and academic papers have outlined the ethical concerns raised by germline genome editing and the opportunities that it may present1, 2-3. To date, no attempts have been made to predict the consequences of altering specific variants associated with polygenic diseases. In this Analysis, we show that polygenic genome editing could theoretically yield extreme red...
作者：Huang, Peiwu; Gao, Weina; Fu, Changying; Wang, Min; Li, Yunguang; Chu, Bizhu; He, An; Li, Yuan; Deng, Xiaomei; Zhang, Yehan; Kong, Qian; Yuan, Jingxiong; Wang, Hebin; Shi, Yu; Gao, Dong; Qin, Renyi; Hunter, Tony; Tian, Ruijun
作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Southern University of Science & Technology; Southern University of Science & Technology; Huazhong University of Science & Technology; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Salk Institute; Shenzhen Bay Laboratory; Bristol-Myers Squibb
摘要：Pancreatic ductal adenocarcinoma (PDAC) has an atypical, highly stromal tumour microenvironment (TME) that profoundly contributes to its poor prognosis1. Here, to better understand the intercellular signalling between cancer and stromal cells directly in PDAC tumours, we developed a multidimensional proteomic strategy called TMEPro. We applied TMEPro to profile the glycosylated secreted and plasma membrane proteome of 100 human pancreatic tissue samples to a great depth, define cell type origi...
作者：Jones, Nicola; Witze, Alexandra; Tollefson, Jeff; Kozlov, Max
作者：Li, Yi-Hao; Chekshin, Nikita; Lu, Yilin; Yu, Jin-Quan
作者单位：Scripps Research Institute
摘要：C-H activation is the most direct way of functionalizing organic molecules. Many advances in this field still require specific directing groups to achieve the necessary activity and selectivity. Developing C-H activation reactions directed by native functional groups is essential for their broad application in synthesis1. Over the past decade, several generations of bifunctional ligands developed have enabled C(sp3)-H activation reactions of free carboxylic acids2, free aliphatic amines3, nati...
作者：Buzzai, Anthony C.; Tueting, Thomas
作者单位：Otto von Guericke University
