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作者：Xia, Frances; Fascianelli, Valeria; Vishwakarma, Nina; Ghinger, Frances Grace; Kwon, Andrew; Gergues, Mark M.; Lalani, Lahin K.; Fusi, Stefano; Kheirbek, Mazen A.
作者单位：University of California System; University of California San Francisco; Columbia University; Columbia University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Columbia University; NewYork-Presbyterian Hospital; NewYork-Presbyterian Hospital; Columbia University; University of California System; University of California San Francisco
摘要：Anhedonia, the diminished drive to seek, value, and learn about rewards, is a core feature of major depressive disorder1, 2-3. The neural underpinnings of anhedonia and how this emotional state drives behaviour remain unclear. Here we investigated the neural code of anhedonia by taking advantage of the fact that when mice are exposed to traumatic social stress, susceptible animals become socially withdrawn and anhedonic, whereas others remain resilient. By performing high-density electrophysio...
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作者：Kim, Jae-Hyun; Daie, Kayvon; Li, Nuo
作者单位：Duke University; Baylor College of Medicine
摘要：Motor skill repertoire can be stably retained over long periods, but the neural mechanism that underlies stable memory storage remains poorly understood1-8. Moreover, it is unknown how existing motor memories are maintained as new motor skills are continuously acquired. Here we tracked neural representation of learned actions throughout a significant portion of the lifespan of a mouse and show that learned actions are stably retained in combination with context, which protects existing memorie...
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作者：Monje, Michelle; Mahdi, Jasia; Majzner, Robbie; Yeom, Kristen W.; Schultz, Liora M.; Richards, Rebecca M.; Barsan, Valentin; Song, Kun-Wei; Kamens, Jen; Baggott, Christina; Kunicki, Michael; Rietberg, Skyler P.; Lim, Alexandria Sung; Reschke, Agnes; Mavroukakis, Sharon; Egeler, Emily; Moon, Jennifer; Patel, Shabnum; Chinnasamy, Harshini; Erickson, Courtney; Jacobs, Ashley; Duh, Allison K.; Tunuguntla, Ramya; Klysz, Dorota Danuta; Fowler, Carley; Green, Sean; Beebe, Barbara; Carr, Casey; Fujimoto, Michelle; Brown, Annie Kathleen; Petersen, Ann-Louise G.; McIntyre, Catherine; Siddiqui, Aman; Lepori-Bui, Nadia; Villar, Katlin; Pham, Kymhuynh; Bove, Rachel; Musa, Eric; Reynolds, Warren D.; Kuo, Adam; Prabhu, Snehit; Rasmussen, Lindsey; Cornell, Timothy T.; Partap, Sonia; Fisher, Paul G.; Campen, Cynthia J.; Grant, Gerald; Prolo, Laura; Ye, Xiaobu; Sahaf, Bita; Davis, Kara L.; Feldman, Steven A.; Ramakrishna, Sneha; Mackall, Crystal
作者单位：Stanford University; Stanford University; Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford Medicine; Stanford University; Johns Hopkins University; Johns Hopkins Medicine; Stanford University
摘要：H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. 1). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models2. Arm A of Phase I trial no. NCT04196413 (ref. 3) administered one intravenous (IV) dose of autologous GD2-CART to patients with H3K27M-mutant pontine (DIPG) or spinal DMG (sDMG) at two dose levels (DL1, 1 x 106 kg-1; DL2, 3 x 106 kg-1) following lymphodepleting chemotherapy. Patients w...
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作者：Mitchinson, Andrew
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作者：Steinkellner, Georg; Kroutil, Wolfgang; Gruber, Karl; Gruber, Christian C.
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作者：Nowogrodzki, Julian
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作者：Pierson, Leah; Pierson, Emma
作者单位：Harvard University; Harvard Medical School; University of California System; University of California Berkeley
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作者：Watson, Traci
摘要：Research in mice points towards a mechanism that keeps old memories from being overwritten.
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作者：Elewaut, Anais; Estivill, Guillem; Bayerl, Felix; Castillon, Leticia; Novatchkova, Maria; Pottendorfer, Elisabeth; Hoffmann-Haas, Lisa; Schonlein, Martin; Nguyen, Trung Viet; Lauss, Martin; Andreatta, Francesco; Vulin, Milica; Krecioch, Izabela; Bayerl, Jonas; Pedde, Anna-Marie; Fabre, Naomi; Holstein, Felix; Cronin, Shona M.; Rieser, Sarah; Laniti, Denarda Dangaj; Barras, David; Coukos, George; Quek, Camelia; Bai, Xinyu; Munoz i Ordono, Miquel; Wiesner, Thomas; Zuber, Johannes; Jonsson, Goran; Bottcher, Jan P.; Vanharanta, Sakari; Obenauf, Anna C.
作者单位：Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); Vienna Biocenter (VBC); University of Vienna; Medical University of Vienna; Technical University of Munich; University of Helsinki; Lund University; University of Lausanne; Ludwig Institute for Cancer Research; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; University of Sydney; Melanoma Institute Australia; University of Sydney; University of Sydney; Medical University of Vienna; University of Helsinki
摘要：The tumour microenvironment is programmed by cancer cells and substantially influences anti-tumour immune responses1,2. Within the tumour microenvironment, CD8+ T cells undergo full effector differentiation and acquire cytotoxic anti-tumour functions in specialized niches3-7. Although interactions with type 1 conventional dendritic cells have been implicated in this process3-5,8-10, the underlying cellular players and molecular mechanisms remain incompletely understood. Here we show that infla...
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作者：Mallapaty, Smriti
