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作者：McClune, Conor James; Liu, Jack Chun-Ting; Wick, Chloe; de la Pena, Ricardo; Lange, Bernd Markus; Fordyce, Polly M.; Sattely, Elizabeth S.
作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Washington State University; Stanford University; Stanford University
摘要：Plants make complex and potent therapeutic molecules1,2, but sourcing these molecules from natural producers or through chemical synthesis is difficult, which limits their use in the clinic. A prominent example is the anti-cancer therapeutic paclitaxel (sold under the brand name Taxol), which is derived from yew trees (Taxus species)3. Identifying the full paclitaxel biosynthetic pathway would enable heterologous production of the drug, but this has yet to be achieved despite half a century of...
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作者：Ma, Dongao; Pang, Jiaxuan; Gotway, Michael B.; Liang, Jianming
作者单位：Arizona State University; Arizona State University-Tempe; Mayo Clinic; Mayo Clinic Phoenix; Arizona State University; Arizona State University-Downtown Phoenix
摘要：Chest radiography frequently serves as baseline imaging for most lung diseases1. Deep learning has great potential for automating the interpretation of chest radiography2. However, existing chest radiographic deep learning models are limited in diagnostic scope, generalizability, adaptability, robustness and extensibility. To overcome these limitations, we have developed Ark+, a foundation model applied to chest radiography and pretrained by cyclically accruing and reusing the knowledge from h...
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作者：Pearson, Helen
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作者：Shi, Qiang; Chen, Yihan; Li, Yang; Qin, Shishang; Yang, Yu; Gao, Yang; Zhu, Linnan; Wang, Dongfang; Zhang, Zemin
作者单位：Peking University; Peking University; Chongqing Medical University; Shenzhen Bay Laboratory
摘要：The multicellular coordination that underlies tissue homeostasis and disease progression is of fundamental interest1, 2, 3, 4-5. However, how diverse cell types are organized within tissue niches for cohesive functioning remains largely unknown. Here we systematically characterized cross-tissue coordinated cellular modules in healthy tissues, uncovering their spatiotemporal dynamics and phenotypic associations, and examined their rewiring in cancer. We first compiled a comprehensive single-cel...
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作者：Ledford, Heidi
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作者：Reynolds, Sam A.; Christie, Alec P.; Dicks, Lynn V.; Jaffer, Sadiq; Madhavapeddy, Anil; Smith, Rebecca K.; Sutherland, William J.
作者单位：University of Cambridge; Imperial College London; University of Cambridge; University of Cambridge; University of Cambridge
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作者：Shi, Yixing; Sun, Qianqian; Jia, Fuchuan; Xie, Xiangyu; Zhou, Xiangyu; Guo, Rong; Zeng, Yangfan; Chen, Shanshan; Guo, Zhenzhen; Sun, Wenli; Guo, Tong; Xia, Yu; Li, Wenlong; Zhang, Li; Shi, Wei; Yu, Yang
作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Institute for Brain Research, Beijing; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
摘要：Chromosomal rearrangements and gene fusions are the initial events in the development of many cancers. Astroblastoma (ABM), a brain cancer of unknown cellular origin and challenging to treat, is associated with diverse in-frame gene fusions, including MN1-BEND2 and MN1-CXXC5 (refs. 1,2). However, it remains unclear whether these gene fusions contribute to tumorigenesis. Here we show in mice that these two ABM-associated fusions converge on similar molecular activities and initiate malignancy s...
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作者：Hassan, Hisham Y.
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作者：[Anonymous]
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作者：Boeck, N. G.
