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作者：Rey, Federico; Vemuganti, Vaibhav
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
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作者：Majd, Homa; Samuel, Ryan M.; Cesiulis, Andrius; Ramirez, Jonathan T.; Kalantari, Ali; Barber, Kevin; Farahvashi, Sina; Ghazizadeh, Zaniar; Majd, Alireza; Chemel, Angeline K.; Richter, Mikayla N.; Das, Subhamoy; Bendrick, Jacqueline L.; Keefe, Matthew G.; Wang, Jeffrey; Shiv, Rahul K.; Bhat, Samyukta; Khoroshkin, Matvei; Yu, Johnny; Nowakowski, Tomasz J.; Wen, Kwun Wah; Goodarzi, Hani; Thapar, Nikhil; Kaltschmidt, Julia A.; Mccann, Conor J.; Fattahi, Faranak
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Stanford University; Stanford University; Stanford University; Stanford University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Stanford University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of London; University College London; Childrens Health Queensland Hospital & Health Service; Queensland Childrens Hospital; University of Queensland; Queensland University of Technology (QUT)
摘要：Gastrointestinal (GI) motility disorders represent a major medical challenge, with few effective therapies available. These disorders often result from dysfunction of inhibitory nitric oxide (NO)-producing motor neurons in the enteric nervous system, which are essential for regulating gut motility. Loss or dysfunction of NO neurons is linked to severe conditions, including achalasia, gastroparesis, intestinal pseudo-obstruction and chronic constipation1,2. Here we introduce a platform based on...
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作者：Fleming, Nic
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作者：Gewin, Virginia
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作者：Liu, Yanan; Xu, Lu; Wu, Mingsong; Wang, Jingjie; Qiu, Dan; Lan, Jiameng; Lu, Junxing; Zhang, Yang; Li, Xin; Zhang, Yuelin
作者单位：Sichuan University; University of British Columbia; Chongqing Normal University; University of British Columbia
摘要：Salicylic acid (SA) is the active ingredient in willow bark that has been used for anti-inflammation and pain relief for centuries. Aspirin, a derivative of SA, is the most widely used medication in human history. SA also acts as a key plant defence hormone1, 2, 3-4. Although SA was known to be produced from chorismate in the model plant Arabidopsis5,6, how it is biosynthesized in plant families outside Brassicaceae remains unclear. Here we report the identification of a conserved pathway for ...
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作者：Aldarondo, Diego; Merel, Josh; Marshall, Jesse D.; Hasenclever, Leonard; Klibaite, Ugne; Gellis, Amanda; Tassa, Yuval; Wayne, Greg; Botvinick, Matthew; Olveczky, Bence P.
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作者：Attipa, Charalampos; Warr, Amanda S.; Epaminondas, Demetris; O'Shea, Marie; Hanton, Andrew J.; Fletcher, Sarah; Malbon, Alexandra; Lyraki, Maria; Hammond, Rachael; Hardas, Alexandros; Zanti, Antria; Loukaidou, Stavroula; Gentil, Michaela; Gunn-Moore, Danielle; Lycett, Samantha J.; Mazeri, Stella; Tait-Burkard, Christine
作者单位：University of Edinburgh; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; University of Edinburgh; University of Edinburgh; University of London; University of London Royal Veterinary College
摘要：Cross-species transmission of coronaviruses (CoVs) poses a serious threat to both animal and human health1, 2-3. While the large RNA genome of CoVs shows relatively low mutation rates, recombination within genera is frequently observed4, 5, 6-7. Companion animals are often overlooked in the transmission cycle of viral diseases; however, the close relationship of feline (FCoV) and canine CoV (CCoV) to human hCoV-229E5,8, as well as the susceptibility of these animals to SARS-CoV-29, highlight t...
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作者：Genkin, Mikhail; Shenoy, Krishna V.; Chandrasekaran, Chandramouli; Engel, Tatiana A.
作者单位：Cold Spring Harbor Laboratory; Stanford University; Howard Hughes Medical Institute; Stanford University; Boston University; Boston University; Boston University; Boston University; Princeton University
摘要：The brain represents sensory variables in the coordinated activity of neural populations, in which tuning curves of single neurons define the geometry of the population code1,2. Whether the same coding principle holds for dynamic cognitive variables remains unknown because internal cognitive processes unfold with a unique time course on single trials observed only in the irregular spiking of heterogeneous neural populations3, 4, 5, 6, 7-8. Here we show the existence of such a population code f...
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作者：Fieldhouse, Rachel
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作者：Fallahshahroudi, Amir; Yousefi Taemeh, Sara; Rodriguez-Montes, Leticia; Trost, Nils; Frank, Dana; Lafrenz, Pascal; Koubek, Jiri; Tellez Jr, Guillermo; Ballantyne, Maeve; Idoko-Akoh, Alewo; Taylor, Lorna; Sherman, Adrian; Davey, Megan; Ma, Cheng; Sorato, Enrico; Johnsson, Martin; Grozou, Christina; Xue, Ying; Liu, Long; Kramer, Guenter; Rubin, Carl-Johan; Cardoso-Moreira, Margarida; McGrew, Mike J.; Kaessmann, Henrik
作者单位：Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Uppsala University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; University of Edinburgh; University of Edinburgh; University of Bristol; Swedish University of Agricultural Sciences; Yangzhou University; Francis Crick Institute
摘要：Birds have a sex chromosome system in which females are heterogametic (ZW) and males are homogametic (ZZ)1. The differentiation of avian sex chromosomes from ancestral autosomes entails the loss of most genes from the W chromosome during evolution1,2. However, the extent to which mechanisms evolved that counterbalance this substantial reduction in female gene dosage remains unclear. Here we report functional in vivo and evolutionary analyses of a Z-linked microRNA (miR-2954) with strong male-b...
