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作者:Dowker, Fay
作者单位:Imperial College London; Perimeter Institute for Theoretical Physics
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作者:Foris, Borbala; Rault, Jean-Loup
作者单位:University of Veterinary Medicine Vienna
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作者:Ji, Haijin; Xiang, Jingwei; Li, Yong; Zheng, Mengting; Yuan, Lixia; Liao, Yaqi; Du, Lin; Li, Zezhuo; Xie, Zhangyating; Huang, Kai; Lin, Xing; Xie, Zhengkun; Shen, Yue; Chen, Ming; Li, Tongjiang; Feng, Guang; Sun, Yongming; Qie, Long; Li, Hui; Zhang, Fangshu; Guo, Rui; Feng, Xuning; Chen, Weihua; Ai, Xinping; Lu, Jun; Huang, Yunhui
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作者:Frankel, Felice
作者单位:Massachusetts Institute of Technology (MIT)
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作者:[Anonymous]
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作者:Christensen, Helen; MackInnon, Andrew
作者单位:University of New South Wales Sydney; Black Dog Institute
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作者:Bird, Sarah; Pawlyn, Charlotte
作者单位:Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust
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作者:Fieldhouse, Rachel
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作者:Joung, Joonyoung F.; Fong, Mun Hong; Casetti, Nicholas; Liles, Jordan P.; Dassanayake, Ne S.; Coley, Connor W.
作者单位:Massachusetts Institute of Technology (MIT); Kookmin University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要:Central to our understanding of chemical reactivity is the principle of mass conservation1, which is fundamental for ensuring physical consistency, balancing equations and guiding reaction design. However, data-driven computational models2, 3, 4, 5, 6, 7, 8-9 for tasks such as reaction product prediction rarely abide by this most basic constraint10, 11, 12-13. Here we recast the problem of reaction prediction as a problem of electron redistribution using the modern deep generative framework of...
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作者:Tang, Haichao; Wei, Zongfang; Zheng, Bei; Cai, Yumeng; Wu, Peihan; Wu, Lulu; Ma, Xiaohe; Chen, Yanqin; Su, Si; Xu, Jinmin; Qiao, Yu; Zhang, Ying; Miao, Juju; Yu, Zijing; Zhao, Yaodong; Xia, Zhen; Zhou, Rongjing; Liu, Jian; Guo, Jufeng; Liu, Zhaoyuan; Xie, Qi; Ginhoux, Florent; Zhao, Luming; Li, Xu; Xia, Bing; Wu, Huanwen; Zhang, Yongdeng; Zhou, Ting
作者单位:Zhejiang University; Westlake Laboratory; Westlake University; Westlake University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Westlake University; Westlake University; Shanghai Jiao Tong University; Chinese Academy of Sciences; UNICANCER; Gustave Roussy
摘要:The dendritic cell (DC)-initiated and sustained cancer immunity cycle is indispensable for effective endogenous and therapeutically mobilized antitumour T cell responses1, 2, 3, 4, 5, 6, 7-8. This necessitates the continuous migration of antigen-carrying DCs from the tumour microenvironment (TME) to the tumour draining lymph nodes (tdLNs)7, 8, 9, 10, 11, 12-13. Here, through longitudinal analysis of human and mouse tumours, we observed a progressive decrease in migratory conventional DCs (mig-...