8080期

最新文章

• Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy AI翻译
  作者：Shi, Guangbin; Miller, Claire; Kuno, Sota; Rey Hipolito, Alejandro G.; El Nagar, Salsabiel; Riboldi, Giulietta M.; Korn, Megan; Tran, Wyatt C.; Wang, Zixuan; Ficaro, Lia; Lin, Tao; Spillier, Quentin; Gamallo-Lana, Begona; Jones, Drew R.; Snuderl, Matija; Song, Soomin C.; Mar, Adam C.; Joyner, Alexandra L.; Sillitoe, Roy V.; Banh, Robert S.; Pacold, Michael E.
  作者单位：New York University; NYU Langone Medical Center; New York University; Baylor College of Medicine; Baylor College Medical Hospital; Memorial Sloan Kettering Cancer Center; New York University; New York University; New York University; New York University; New York University; NYU Langone Medical Center
  摘要：Decreased brain levels of coenzyme Q(10) (CoQ(10)), an endogenously synthesized lipophilic antioxidant(1,2), underpin encephalopathy in primary CoQ(10) deficiencies(3,4) and are associated with common neurodegenerative diseases and the ageing process(5,6). CoQ(10) supplementation does not increase CoQ(10) pools in the brain or in other tissues. The recent discovery of the mammalian CoQ(10) headgroup synthesis pathway, in which 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) makes 4-hyd...
• Systematic attribution of heatwaves to the emissions of carbon majors AI翻译
  作者：Quilcaille, Yann; Gudmundsson, Lukas; Schumacher, Dominik L.; Gasser, Thomas; Heede, Richard; Heri, Corina; Lejeune, Quentin; Nath, Shruti; Naveau, Philippe; Thiery, Wim; Schleussner, Carl-Friedrich; Seneviratne, Sonia I.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; International Institute for Applied Systems Analysis (IIASA); Tilburg University; University of Oxford; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Vrije Universiteit Brussel; Humboldt University of Berlin; Humboldt University of Berlin
  摘要：Extreme event attribution assesses how climate change affected climate extremes, but typically focuses on single events(1-4). Furthermore, these attributions rarely quantify the extent to which anthropogenic actors have contributed to these events(5,6). Here we show that climate change made 213 historical heatwaves reported over 2000-2023 more likely and more intense, to which each of the 180 carbon majors (fossil fuel and cement producers) substantially contributed. This work relies on the ex...
• ACLY inhibition promotes tumour immunity and suppresses liver cancer AI翻译
  作者：Gautam, Jaya; Wu, Jianhan; Lally, James S. V.; McNicol, Jamie D.; Fayyazi, Russta; Ahmadi, Elham; Oniciu, Daniela Carmen; Heaton, Spencer; Newton, Roger S.; Rehal, Sonia; Bhattacharya, Dipankar; Di Pastena, Fiorella; Binh Nguyen; Valvano, Celina M.; Townsend, Logan K.; Banskota, Suhrid; Batchuluun, Battsetseg; Jabile, Maria Joy Therese; Payne, Alice; Lu, Junfeng; Desjardins, Eric M.; Kubota, Naoto; Tsakiridis, Evangelia E.; Mistry, Bejal; Aganostopoulos, Alex; Houde, Vanessa; Dansercoer, Ann; Verschueren, Koen H. G.; Savvides, Savvas N.; Hammill, Joanne A.; Bezverbnaya, Ksenia; Muti, Paola; Tsakiridis, Theodoros; Dai, Wenting; Jiang, Lei; Hoshida, Yujin; Larche, Mark; Bramson, Jonathan L.; Friedman, Scott L.; Verstraete, Kenneth; Wang, Dongdong; Steinberg, Gregory R.
  作者单位：McMaster University; McMaster University; McMaster University; State University System of Florida; University of Florida; Icahn School of Medicine at Mount Sinai; McMaster University; McMaster University; University of Texas System; University of Texas Southwestern Medical Center; Ghent University; Flanders Institute for Biotechnology (VIB); Ghent University; City of Hope; McMaster University
  摘要：Immunosuppressive tumour microenvironments are common in cancers such as metabolic dysfunction-associated steatohepatitis (MASH)-driven hepatocellular carcinoma (HCC) (MASH-HCC)(1-3). Although immune cell metabolism influences effector function, the effect of tumour metabolism on immunogenicity is less understood(4). ATP citrate lyase (ACLY) links substrate availability and mitochondrial metabolism with lipid biosynthesis and gene regulation(5-7). Although ACLY inhibition shows antiproliferati...
• Spatiotemporal faunal connectivity across global sea floors AI翻译
  作者：O'Hara, Timothy D.; Hugall, Andrew F.; Haines, Margaret L.; Weber, Alexandra A. -T.; Eichsteller, Angelina; Brogger, Martin I.; Eleaume, Marc; Fujita, Toshihiko; Kongsrud, Jon A.; Arbizu, Pedro Martinez; Mills, Sadie; Olbers, Jennifer M.; Paulay, Gustav; Ramil, Fran; Samadi, Sarah; Sands, Chester J.; Sellanes, Javier; Solis-Marin, Francisco A.; Moussalli, Adnan
  作者单位：Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Museum National d'Histoire Naturelle (MNHN); National Museum of Nature and Science; University of Bergen; Earth Sciences New Zealand; National Institute of Water & Atmospheric Research (NIWA) - New Zealand; State University System of Florida; University of Florida; Universidade de Vigo; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Sorbonne Universite; Museum National d'Histoire Naturelle (MNHN); Ecole Pratique des Hautes Etudes (EPHE); UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Universidad Catolica del Norte; Universidad Catolica del Norte; Universidad Nacional Autonoma de Mexico
  摘要：Our knowledge of biogeographic patterns and processes in the deep sea has been limited by the lack of integrated datasets that cover its vast extent(1). Here we analyse a new global dataset of genomic DNA sequences, spanning an entire taxonomic class of benthic invertebrates (Ophiuroidea), to obtain a broad understanding of phylogenetic divergence and biotic movement across all oceans, from coastal margins down to the abyssal plains. We show that regional faunas on the continental shelf are ph...
• 'LinkedIn is like air to me': the scientists who've cracked professional networking AI翻译
  作者：Conlon, Anne Marie
• THIS IS THE WORLD'S LARGEST 'MOSQUITO FACTORY': ITS GOAL IS TO STOP DENGUE AI翻译
  作者：Lenharo, Mariana
• A revolution is sweeping Europe's farms: can it save agriculture? AI翻译
  作者：Reese, April
• How did the oldest star clusters form? AI翻译
  作者：Lahen, Natalia
  作者单位：Max Planck Society
  摘要：A computational model of the early-to-present-day Universe predicts that some of the first stars formed in structures that challenge conventional classification.
• Synthetic data can benefit medical research - but risks must be recognized AI翻译
  作者：[Anonymous]
  摘要：Artificially generated data can help to train AI models when real data are scant, but more focus is needed on validating the results.
• Design of highly functional genome editors by modelling CRISPR-Cas sequences AI翻译
  作者：Ruffolo, Jeffrey A.; Nayfach, Stephen; Gallagher, Joseph; Bhatnagar, Aadyot; Beazer, Joel; Hussain, Riffat; Russ, Jordan; Yip, Jennifer; Hill, Emily; Pacesa, Martin; Meeske, Alexander J.; Cameron, Peter; Madani, Ali
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Institute of Bioinformatics; University of Washington; University of Washington Seattle
  摘要：Gene editing has the potential to solve fundamental challenges in agriculture, biotechnology and human health. CRISPR-based gene editors derived from microorganisms, although powerful, often show notable functional tradeoffs when ported into non-native environments, such as human cells(1). Artificial-intelligence-enabled design provides a powerful alternative with the potential to bypass evolutionary constraints and generate editors with optimal properties. Here, using large language models(2)...