作者：Lambrecht, Bart N.
作者单位：Flanders Institute for Biotechnology (VIB); Ghent University
作者：Dresden, Brooke P.; Alcorn, John F.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
作者：Chia, Shi B.; Johnson, Bryan J.; Hu, Junxiao; Valenca-Pereira, Felipe; Chadeau-Hyam, Marc; Guntoro, Fernando; Montgomery, Hugh; Boorgula, Meher P.; Sreekanth, Varsha; Goodspeed, Andrew; Davenport, Bennett; De Dominici, Marco; Zaberezhnyy, Vadym; Schleicher, Wolfgang E.; Gao, Dexiang; Cadar, Andreia N.; Petriz-Otano, Lucia; Papanicolaou, Michael; Beheshti, Afshin; Baylin, Stephen B.; Guarnieri, Joseph W.; Wallace, Douglas C.; Costello, James C.; Bartley, Jenna M.; Morrison, Thomas E.; Vermeulen, Roel; Aguirre-Ghiso, Julio A.; Rincon, Mercedes; DeGregori, James
作者单位：University of Colorado System; University of Colorado Anschutz; University of Colorado System; University of Colorado Anschutz; University of Colorado System; University of Colorado Anschutz; University of Colorado System; University of Colorado Anschutz; Utrecht University; Imperial College London; Imperial College London; Imperial College London; University of London; University College London; University of Colorado System; University of Colorado Anschutz; University of Colorado System; University of Colorado Anschutz; University of Connecticut; University of Connecticut; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Van Andel Institute; Van Andel Research Institute; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Utrecht University; Utrecht University Medical Center
摘要：Breast cancer is the second most common cancer globally, with most deaths caused by metastatic disease, often following long periods of clinical dormancy(1). Understanding the mechanisms that disrupt the quiescence of dormant disseminated cancer cells (DCCs) is crucial for addressing metastatic progression. Infections caused by respiratory viruses such as influenza and SARS-CoV-2 trigger both local and systemic inflammation(2,3). Here we demonstrate, in mice, that influenza and SARS-CoV-2 infe...
作者：Pokharna, Aditya; Stockwell, Imogen; Ivica, Josip; Singh, Bishal; Schwab, Johannes; Vega-Gutierrez, Carlos; Herguedas, Beatriz; Cais, Ondrej; Krieger, James M.; Greger, Ingo H.
作者单位：University of Texas System; UTMD Anderson Cancer Center; UK Research & Innovation (UKRI); MRC Laboratory Molecular Biology; Medical Research Council UK (MRC); University of Zaragoza; University of Zaragoza; Consejo Superior de Investigaciones Cientificas (CSIC)
摘要：AMPA-type glutamate receptors (AMPARs) mediate the majority of excitatory neurotransmission in the brain(1). Assembled from combinations of four core subunits, GluA1-4 and around 20 auxiliary subunits, their molecular diversity tunes information transfer and storage in a brain-circuit-specific manner. GluA3, a subtype strongly associated with disease(2), functions as both a fast-transmitting Ca2+-permeable AMPAR at sensory synapses(3), and as a Ca2+-impermeable receptor at cortical synapses(4,...
