2025

最新文章

• The origin of the oldest solid objects in the Solar System AI翻译
  作者：Ciesla, Fred
  作者单位：University of Chicago
• Sex differences in skin-cancer risk are linked to oestrogen levels AI翻译
  作者：Meierjohann, Svenja
  作者单位：University of Wurzburg
• Rare find: interstellar visitor seen blazing through our Solar System AI翻译
  作者：Jones, Nicola
• A canine friend to a feline family AI翻译
  作者：[Anonymous]
• China's shift towards 'organized research': how can coordination and innovation co-exist? AI翻译
  作者：Han, Shuangmiao; Xie, Jing
  作者单位：Zhejiang University; Zhejiang University of Finance & Economics
• Memory gets a boost from positive emotion AI翻译
  作者：[Anonymous]
• Refractory solid condensation detected in an embedded protoplanetary disk AI翻译
  作者：McClure, M. K.; Van't Hoff, Merel; Francis, Logan; Bergin, Edwin; Rocha, Will R. M.; Sturm, J. A.; Harsono, Daniel; van Dishoeck, Ewine F.; Black, John H.; Noble, J. A.; Qasim, D.; Dartois, E.
  作者单位：Leiden University - Excl LUMC; Leiden University; University of Michigan System; University of Michigan; Purdue University System; Purdue University; Leiden University - Excl LUMC; Leiden University; National Tsing Hua University; Chalmers University of Technology; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Southwest Research Institute; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay
  摘要：Terrestrial planets and small bodies in our Solar System are theorized to have assembled from interstellar solids mixed with rocky solids that precipitated from a hot, cooling gas1,2. The first high-temperature minerals to recondense from this gaseous reservoir start the clock on planet formation3,4. However, the production mechanism of this initial hot gas and its importance to planet formation in other systems are unclear. Here we report the astronomical detection of this t = 0 moment, captu...
• Research-integrity sleuths say their work is being 'twisted' to undermine science AI翻译
  作者：Naddaf, Miryam
• Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin AI翻译
  作者：Raymond, Jeremy H.; Aktary, Zackie; Pouteaux, Marie; Petit, Valerie; Luciani, Flavie; Wehbe, Maria; Gizzi, Patrick; Bourban, Claire; Decaudin, Didier; Nemati, Fariba; Martianov, Igor; Davidson, Irwin; Tomasetto, Catherine-Laure; White, Richard M.; Mahuteau-Betzer, Florence; Vergier, Beatrice; Larue, Lionel; Delmas, Veronique
  作者单位：Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris Saclay; Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; University of Oxford; Ludwig Institute for Cancer Research; UNICANCER; Universite PSL; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux; CHU Bordeaux; Universite de Bordeaux; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Sex inequalities in cancer are well documented, but the current limited understanding is hindering advances in precision medicine and therapies1. Consideration of ethnicity, age and sex is essential for the management of cancer patients because they underlie important differences in both incidence and response to treatment2,3. Age-related hormone production, which is a consistent divergence between the sexes, is underestimated in cancers that are not recognized as being hormone dependent4, 5-6...
• Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1 AI翻译
  作者：Gulati, Ashutosh; Ahn, Do-Hwan; Suades, Albert; Hult, Yurie; Wolf, Gernot; Iwata, So; Superti-Furga, Giulio; Nomura, Norimichi; Drew, David
  作者单位：Stockholm University; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences; Kyoto University; Medical University of Vienna
  摘要：ATP generated in the mitochondria is exported by an ADP/ATP carrier of the SLC25 family1. The endoplasmic reticulum (ER) cannot synthesize ATP but must import cytoplasmic ATP to energize protein folding, quality control and trafficking2,3. It was recently proposed that a member of the nucleotide sugar transporter family, termed SLC35B1 (also known as AXER), is not a nucleotide sugar transporter but a long-sought-after ER importer of ATP4. Here we report that human SLC35B1 does not bind nucleot...