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作者：[Anonymous]
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作者：Kosicki, Michael; Zhang, Boyang; Hecht, Vivian; Pampari, Anusri; Cook, Laura E.; Slaven, Neil; Akiyama, Jennifer A.; Plajzer-Frick, Ingrid; Novak, Catherine S.; Kato, Momoe; Tran, Stella; Hunter, Riana D.; von Maydell, Kianna; Barton, Sarah; Beckman, Erik; Zhu, Yiwen; Dickel, Diane E.; Kundaje, Anshul; Visel, Axel; Pennacchio, Len A.
作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Stanford University; Stanford University; University of California System; University of California Merced; University of California System; University of California Berkeley
摘要：Distant-acting enhancers are central to human development1. However, our limited understanding of their functional sequence features prevents the interpretation of enhancer mutations in disease2. Here we determined the functional sensitivity to mutagenesis of human developmental enhancers in vivo. Focusing on seven enhancers that are active in the developing brain, heart, limb and face, we created over 1,700 transgenic mice for over 260 mutagenized enhancer alleles. Systematic mutation of 12-b...
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作者：Ahart, Jenna
摘要：Democrats hosted a protest event featuring 'things we'll never know' because of the US government's cuts to science.
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作者：Wild, Sarah
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作者：Zhou, Jingxuan; Zhou, Jingyuan; Wan, Zhong; Qian, Qi; Ren, Huaying; Yan, Xingxu; Zhou, Boxuan; Zhang, Ao; Pan, Xiaoqing; Fang, Wuzhang; Ping, Yuan; Sofer, Zdenek; Huang, Yu; Duan, Xiangfeng
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Chemistry & Technology, Prague; University of California System; University of California Los Angeles
摘要：Tailoring magnetic ordering in solid-state materials is essential for emerging spintronics1,2. However, substitutional lattice doping in magnetic semiconductors is often constrained by the low solubility of magnetic elements3, 4-5, limiting the maximum achievable doping concentration (for example, less than 5%) and ferromagnetic ordering temperature6. The intercalation of magnetic elements in layered two-dimensional atomic crystals (2DACs) without breaking in-plane covalent bonds offers an alt...
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作者：Piffko, Andras; Yang, Kaiting; Panda, Arpit; Heide, Janna; Tesak, Krystyna; Wen, Chuangyu; Zawieracz, Katarzyna; Wang, Liangliang; Naccasha, Emile Z.; Bugno, Jason; Fu, Yanbin; Chen, Dapeng; Donle, Leonhard; Lengyel, Ernst; Tilley, Douglas G.; Mack, Matthias; Rock, Ronald S.; Chmura, Steven J.; Vokes, Everett E.; He, Chuan; Pitroda, Sean P.; Liang, Hua Laura; Weichselbaum, Ralph R.
作者单位：University of Chicago; University of Chicago; University of Hamburg; University Medical Center Hamburg-Eppendorf; South China University of Technology; University of Chicago; University of Chicago; University of Chicago; Howard Hughes Medical Institute; University of Chicago; University of Chicago; Chinese Academy of Sciences; Institute of Microbiology, CAS; University of Chicago; Cornell University; Weill Cornell Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Regensburg; University of Chicago
摘要：The anti-tumour effect of radiotherapy beyond the treatment field-the abscopal effect-has garnered much interest1. However, the potentially deleterious effect of radiation in promoting metastasis is less well studied. Here we show that radiotherapy induces the expression of the EGFR ligand amphiregulin in tumour cells, which reprogrammes EGFR-expressing myeloid cells toward an immunosuppressive phenotype and reduces phagocytosis. This stimulates distant metastasis growth in human patients and ...
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作者：Conde, Joao
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作者：Montesinos-Tubee, Daniel B.
作者单位：Universidad Cientifica del Sur (CIENTIFICA)
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作者：Zmigrod, Leor; Moorosi, Nyalleng; Sultana, Farhana; Abalkina, Anna; Odgers, Candice L.; Libonati, Renata; Gomez-Marin, Alex; McLemore, Monica; Wojcik, Genevieve L.; Park, Tae Jung
作者单位：Syracuse University; Free University of Berlin; University of California System; University of California Irvine; Universidade Federal do Rio de Janeiro; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante (IN); New York University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Korea Advanced Institute of Science & Technology (KAIST)
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作者：Fieldhouse, Rachel
