2025

最新文章

• Connectomics of predicted Sst transcriptomic types in mouse visual cortex AI翻译
  作者：Gamlin, Clare R.; Schneider-Mizell, Casey M.; Mallory, Matthew; Elabbady, Leila; Gouwens, Nathan; Williams, Grace; Mukora, Alice; Dalley, Rachel; Bodor, Agnes L.; Brittain, Derrick; Buchanan, JoAnn; Bumbarger, Daniel J.; Joyce, Emily; Kapner, Daniel; Kinn, Sam; Mahalingam, Gayathri; Seshamani, Sharmishtaa; Takeno, Marc; Torres, Russel; Yin, Wenjing; Nicovich, Philip R.; Bae, J. Alexander; Castro, Manuel A.; Dorkenwald, Sven; Halageri, Akhilesh; Jia, Zhen; Jordan, Chris; Kemnitz, Nico; Lee, Kisuk; Li, Kai; Lu, Ran; Macrina, Thomas; Mitchell, Eric; Mondal, Shanka Subhra; Mu, Shang; Nehoran, Barak; Popovych, Sergiy; Silversmith, William; Turner, Nicholas L.; Wong, William; Wu, Jingpeng; Yu, Szi-chieh; Berg, Jim; Jarsky, Tim; Lee, Brian; Seung, H. Sebastian; Zeng, Hongkui; Reid, R. Clay; Collman, Forrest; da Costa, Nuno Macarico; Sorensen, Staci A.
  作者单位：Allen Institute for Brain Science; Princeton University; Princeton University; Princeton University; Massachusetts Institute of Technology (MIT); University of Washington; University of Washington Seattle
  摘要：Neural circuit function is shaped both by the cell types that comprise the circuit and the connections between them1. Neural cell types have previously been defined by morphology2,3, electrophysiology4, transcriptomic expression5,6, connectivity7, 8-9 or a combination of such modalities10, 11-12. The Patch-seq technique enables the characterization of morphology, electrophysiology and transcriptomic properties from individual cells13, 14-15. These properties were integrated to define 28 inhibi...
• Mutations that accrue through life set the stage for stomach cancer AI翻译
  作者：Oddy, Callum; Jansen, Marnix
  作者单位：University of London; University College London
• 'One of the darkest days': NIH purges agency leadership amid mass lay-offs AI翻译
  作者：Kozlov, Max
• NEURD offers automated proofreading and feature extraction for connectomics AI翻译
  作者：Celii, Brendan; Papadopoulos, Stelios; Ding, Zhuokun; Fahey, Paul G.; Wang, Eric; Papadopoulos, Christos; Kunin, Alexander B.; Patel, Saumil; Bae, J. Alexander; Bodor, Agnes L.; Brittain, Derrick; Buchanan, Joann; Bumbarger, Daniel J.; Castro, Manuel A.; Cobos, Erick; Dorkenwald, Sven; Elabbady, Leila; Halageri, Akhilesh; Jia, Zhen; Jordan, Chris; Kapner, Dan; Kemnitz, Nico; Kinn, Sam; Lee, Kisuk; Li, Kai; Lu, Ran; Macrina, Thomas; Mahalingam, Gayathri; Mitchell, Eric; Mondal, Shanka Subhra; Mu, Shang; Nehoran, Barak; Popovych, Sergiy; Schneider-Mizell, Casey M.; Silversmith, William; Takeno, Marc; Torres, Russel; Turner, Nicholas L.; Wong, William; Wu, Jingpeng; Yu, Szi-chieh; Yin, Wenjing; Xenes, Daniel; Kitchell, Lindsey M.; Rivlin, Patricia K.; Rose, Victoria A.; Bishop, Caitlyn A.; Wester, Brock; Froudarakis, Emmanouil; Walker, Edgar Y.; Sinz, Fabian; Seung, H. Sebastian; Collman, Forrest; da Costa, Nuno Macarico; Reid, R. Clay; Pitkow, Xaq; Tolias, Andreas S.; Reimer, Jacob
  作者单位：Baylor College of Medicine; Baylor College of Medicine; Rice University; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; Stanford University; Stanford University; Stanford University; Stanford University; Creighton University; Princeton University; Princeton University; Allen Institute for Brain Science; Princeton University; Massachusetts Institute of Technology (MIT); Foundation for Research & Technology - Hellas (FORTH); University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Eberhard Karls University of Tubingen; University of Gottingen; University of Gottingen; Carnegie Mellon University; Carnegie Mellon University; Rice University; Stanford University; Stanford University
  摘要：We are in the era of millimetre-scale electron microscopy volumes collected at nanometre resolution1,2. Dense reconstruction of cellular compartments in these electron microscopy volumes has been enabled by recent advances in machine learning3, 4, 5-6. Automated segmentation methods produce exceptionally accurate reconstructions of cells, but post hoc proofreading is still required to generate large connectomes that are free of merge and split errors. The elaborate 3D meshes of neurons in thes...
• Universal photonic artificial intelligence acceleration AI翻译
  作者：Ahmed, Sufi R.; Baghdadi, Reza; Bernadskiy, Mikhail; Bowman, Nate; Braid, Ryan; Carr, Jim; Chen, Chen; Ciccarella, Pietro; Cole, Matthew; Cooke, John; Desai, Kishor; Dorta, Carlos; Elmhurst, Jonathan; Gardiner, Bryce; Greenwald, Elliot; Gupta, Shashank; Husbands, Parry; Jones, Brian; Kopa, Anthony; Lee, Ho John; Madhavan, Arulselvan; Mendrela, Adam; Moore, Nicholas; Nair, Lakshmi; Om, Aditya; Patel, Subie; Patro, Rutayan; Pellowski, Rob; Radhakrishnani, Esha; Sane, Sandeep; Sarkis, Nicholas; Stadolnik, Joe; Tymchenko, Mykhailo; Wang, Gongyu; Winikka, Kurt; Wleklinski, Alexandra; Zelman, Josh; Ho, Richard; Jain, Ritesh; Basumallik, Ayon; Bunandar, Darius; Harris, Nicholas C.
  作者单位：OpenAI
  摘要：Over the past decade, photonics research has explored accelerated tensor operations, foundational to artificial intelligence (AI) and deep learning1, 2, 3-4, as a path towards enhanced energy efficiency and performance5, 6, 7, 8, 9, 10, 11, 12, 13-14. The field is centrally motivated by finding alternative technologies to extend computational progress in a post-Moore's law and Dennard scaling era15, 16, 17, 18-19. Despite these advances, no photonic chip has achieved the precision necessary fo...
• An integrated large-scale photonic accelerator with ultralow latency AI翻译
  作者：Hua, Shiyue; Divita, Erwan; Yu, Shanshan; Peng, Bo; Roques-Carmes, Charles; Su, Zhan; Chen, Zhang; Bai, Yanfei; Zou, Jinghui; Zhu, Yunpeng; Xu, Yelong; Lu, Cheng-kuan; Di, Yuemiao; Chen, Hui; Jiang, Lushan; Wang, Lijie; Ou, Longwu; Zhang, Chaohong; Chen, Junjie; Zhang, Wen; Zhu, Hongyan; Kuang, Weijun; Wang, Long; Meng, Huaiyu; Steinman, Maurice; Shen, Yichen
  作者单位：Stanford University
  摘要：Integrated photonics, particularly silicon photonics, have emerged as cutting-edge technology driven by promising applications such as short-reach communications, autonomous driving, biosensing and photonic computing1, 2, 3-4. As advances in AI lead to growing computing demands, photonic computing has gained considerable attention as an appealing candidate. Nonetheless, there are substantial technical challenges in the scaling up of integrated photonics systems to realize these advantages, suc...
• Why an overreliance on AI-driven modelling is bad for science AI翻译
  作者：Narayanan, Arvind; Kapoor, Sayash
  作者单位：Princeton University; Princeton University
• 'Now is not the time for despair' - how scientists can take a stand against political interference AI翻译
  作者：Tormos-Aponte, Fernando
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
• Deconstruction of rubber via C-H amination and aza-Cope rearrangement AI翻译
  作者：Towell, Sydney E.; Ratushnyy, Maxim; Cooke, Lauren S.; Lewis, Geoffrey M.; Zhukhovitskiy, Aleksandr V.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Michigan System; University of Michigan
  摘要：Limited strategies exist for chemical recycling of commodity diene polymers, like those found in tyres1, 2-3. Here we apply C-H amination and backbone rearrangement of polymers to deconstruct these materials into precursors for epoxy resins. Specifically, we develop a sulfur diimide reagent4,5 that enables up to about 35% allylic amination of diene polymers and rubber. Then, we apply the cationic 2-aza-Cope rearrangement to deconstruct aminated diene polymers. In a model system, we see molecul...
• A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein AI翻译
  作者：Van Damme, Ellen; Abeywickrema, Pravien; Yin, Yanting; Xie, Jiexiong; Jacobs, Sofie; Mann, Mandeep Kaur; Doijen, Jordi; Miller, Robyn; Piassek, Madison; Marsili, Simone; Subramanian, Murali; Gottlieb, Leah; Abdelnabi, Rana; Van Gool, Michiel; van den Broeck, Nick; De Pauw, Ines; Diels, Annick; Vermeulen, Peter; Temmerman, Koen; Scobey, Trevor; Mattocks, Melissa; Schaefer, Alexandra; Jochmans, Dirk; De Jonghe, Steven; Leyssen, Pieter; Chiu, Winston; Toro, Mayra Diosa; Zwaagstra, Marleen; Leijs, Anouk A.; De Gruyter, Heidi L. M.; Buyck, Christophe; van den Heede, Klaas; Jacobs, Frank; van den Eynde, Christel; Thijs, Laura; Raeymaekers, Valerie; Miller, Seth; Del Rosario, Amanda; Neyts, Johan; Peeters, Danielle; Baric, Ralph S.; van Kuppeveld, Frank J. M.; Snijder, Eric J.; van Hemert, Martijn J.; Monshouwer, Mario; Sharma, Sujata; Draghia-Akli, Ruxandra; Koul, Anil; Van Loock, Marnix
  作者单位：Johnson & Johnson; Johson & Johnson Belgium; Janssen Pharmaceuticals; Johnson & Johnson; Janssen Pharmaceuticals; Johnson & Johnson; Janssen Pharmaceuticals; Johnson & Johnson; Johnson & Johnson Spain; Johnson & Johnson; Janssen Pharmaceuticals; KU Leuven; Johnson & Johnson; Janssen Pharmaceuticals; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Utrecht University; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Johnson & Johnson; Johson & Johnson Belgium; Janssen Pharmaceuticals; Gilead Sciences; Royal Netherlands Academy of Arts & Sciences; Royal Netherlands Institute of Southeast Asian & Caribbean Studies (KITLV-KNAW)
  摘要：The membrane (M) protein of betacoronaviruses is well conserved and has a key role in viral assembly1,2. Here we describe the identification of JNJ-9676, a small-molecule inhibitor targeting the coronavirus M protein. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and sarbecovirus strains from bat and pangolin zoonotic origin. Using cryogenic electron microscopy (cryo-EM), we determined a binding pocket of JNJ-9676 formed by the transmembrane domains o...