Science

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• Embed equity throughout innovation AI翻译
  作者：Wailoo, Keith A.; Dzau, Victor J.; Yamamoto, Keith R.
  作者单位：Princeton University; National Academies of Sciences, Engineering & Medicine; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：The social benefit of technologies is frequently unevenly realized across the United States. Rural communities, individuals with disabilities, and historically marginalized groups face out-of-reach costs or lack access to products that meet their needs. Blame is typically placed on complicated regulatory processes or complex delivery systems, but this response neglects the problem that equity is not baked into the nation's innovation process at any stage. The United States needs to rethink its...
• Oxidative addition of an alkyl halide to form a stable Cu(III) product AI翻译
  作者：Luo, Yongrui; Li, Yuli; Wu, Jian; Xue, Xiao-Song; Hartwig, John F.; Shen, Qilong
  作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Organic Chemistry, CAS; University of California System; University of California Berkeley
  摘要：The step that cleaves the carbon-halogen bond in copper-catalyzed cross-coupling reactions remains ill defined because of the multiple redox manifolds available to copper and the instability of the highvalent copper product formed. We report the oxidative addition of a-haloacetonitrile to ionic and neutral copper(I) complexes to form previously elusive but here fully characterized copper(III) complexes. The stability of these complexes stems from the strong Cu-CF3 bond and the high barrier for...
• Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors AI翻译
  作者：Lv, Xiangdong; Lu, Xuan; Cao, Jin; Luo, Qin; Ding, Yao; Peng, Fanglue; Pataer, Apar; Lu, Dong; Han, Dong; Malmberg, Eric; Chan, Doug W.; Wang, Xiaoran; Savage, Sara R.; Mao, Sufeng; Yu, Jingjing; Peng, Fei; Yan, Liang; Meng, Huan; Maneix, Laure; Han, Yumin; Chen, Yiwen; Yao, Wantong; Chang, Eric C.; Catic, Andre; Lin, Xia; Miles, George; Huang, Pengxiang; Sun, Zheng; Burt, Bryan; Wang, Huamin; Wang, Jin; Yao, Qizhi Cathy; Zhang, Bing; Roth, Jack A.; O'Malley, Bert W.; Ellis, Matthew J.; Rimawi, Mothaffar F.; Ying, Haoqiang; Chen, Xi
  作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; AstraZeneca
  摘要：Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of multiple KRASi-resistance mechanisms. Inactivation of oncogenic KRAS down-regulated both the heat shock response and the inositol-requiring enzyme 1a (IRE1a) branch of the unfolded protein response, causing severe proteostasis disturbances. However, IRE1a was selectively reactivated in an...
• Seizure of Nicaraguan university deals blow to nation's scientists AI翻译
  作者：Karath, Kata
• Establishing a new standard of care for calculus using trials with randomized student allocation AI翻译
  作者：Kramer, Laird; Fuller, Edgar; Watson, Charity; Castillo, Adam; Oliva, Pablo Duran; Potvin, Geoff
  作者单位：State University System of Florida; Florida International University; State University System of Florida; Florida International University; State University System of Florida; Florida International University; State University System of Florida; Florida International University; Virginia Commonwealth University
  摘要：Calculus, the study of change in processes and systems, serves as the foundation for many STEM disciplines. Traditional, lecture-based calculus instruction may present a barrier for students seeking STEM degrees, limit their access to STEM professions, and block their potential to address society's challenges. A large-scale pragmatic trial with randomized student allocation was conducted to compare two calculus instruction styles: active student engagement (treatment condition) versus traditio...
• In Other Journals AI翻译
  作者：[Anonymous]
• News at a glance AI翻译
  作者：Brainard, Jeffrey
• 撤稿声明: Hierarchical organization of guidance receptors: Silencing of netrin attraction by Slit through a Robo/DCC receptor complex (Retraction of Vol 29, art no 1928, 2001) AI翻译
  作者：Tessier-Lavigne, Marc
  作者单位：Stanford University
• Observations of a black hole x-ray binary indicate formation of a magnetically arrested disk AI翻译
  作者：You, Bei; Cao, Xinwu; Yan, Zhen; Hameury, Jean-Marie; Czerny, Bozena; Wu, Yue; Xia, Tianyu; Sikora, Marek; Zhang, Shuang-Nan; Du, Pu; Zycki, Piotr T.
  作者单位：Wuhan University; Zhejiang University; Chinese Academy of Sciences; Shanghai Astronomical Observatory, CAS; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Polish Academy of Sciences; Center for Theoretical Physics - Polish Academy of Sciences; Nanjing University; Nanjing University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Polish Academy of Sciences; Nicolaus Copernicus Astronomical Center of the Polish Academy of Sciences; Chinese Academy of Sciences; Institute of High Energy Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Accretion of material onto a black hole drags any magnetic fields present inwards, increasing their strength. Theory predicts that sufficiently strong magnetic fields can halt the accretion flow, producing a magnetically arrested disk (MAD). We analyzed archival multiwavelength observations of an outburst from the black hole x-ray binary MAXI J1820+070 in 2018. The radio and optical fluxes were delayed compared with the x-ray flux by about 8 and 17 days, respectively. We interpret this as evid...
• A machine-learning tool to predict substrate-adaptive conditions for Pd-catalyzed C-N couplings AI翻译
  作者：Rinehart, N. Ian; Saunthwal, Rakesh K.; Wellauer, Joel; Zahrt, Andrew F.; Schlemper, Lukas; Shved, Alexander S.; Bigler, Raphael; Fantasia, Serena; Denmark, Scott E.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Machine-learning methods have great potential to accelerate the identification of reaction conditions for chemical transformations. A tool that gives substrate-adaptive conditions for palladium (Pd)-catalyzed carbon-nitrogen (C-N) couplings is presented. The design and construction of this tool required the generation of an experimental dataset that explores a diverse network of reactant pairings across a set of reaction conditions. A large scope of C-N couplings was actively learned by neural...