Science

最新文章

• Modeling cartel size to inform violence reduction in Mexico AI翻译
  作者：Caulkins, Jonathan P.; Kilmer, Beau; Reuter, Peter
  作者单位：Carnegie Mellon University; RAND Corporation; Rand Health; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park
  摘要：Immense violence and corruption in Mexico, and their connections to illegal drugs in the United States, are a great problem of our time. Mexico's homicide rate in 2022 was 25 per 100,000, similar to Colombia's and more than triple the US rate. Measuring corruption is notoriously difficult, but some Mexican criminal organizations have a history of intimidating and bribing government officials (1). On page 1312 of this issue, Prieto-Curiel et al. (2) take on two important tasks: estimating how m...
• Polio eradication effort struggles with end game AI翻译
  作者：Cohen, Jon
  摘要：Tom Frieden, co-author of critical new report, explains the repeated failures of decadeslong campaign
• Solar max set to arrive sooner than expected-and stronger AI翻译
  作者：Savitsky, Zack
  摘要：A feisty Sun threatens satellites and electric grids, highlighting need for better forecasts
• Impacts of metal mining on river systems: a global assessment AI翻译
  作者：Macklin, M. G.; Thomas, C. J.; Mudbhatkal, A.; Brewer, P. A.; Hudson-Edwards, K. A.; Lewin, J.; Scussolini, P.; Eilander, D.; Lechner, A.; Owen, J.; Bird, G.; Kemp, D.; Mangalaa, K. R.
  作者单位：University of Lincoln; Massey University; La Trobe University; University of Namibia; Aberystwyth University; University of Exeter; University of Exeter; Vrije Universiteit Amsterdam; Deltares; Vrije Universiteit Amsterdam; University of the Free State; Bangor University; University of Queensland; Ministry of Earth Sciences (MoES) - India
  摘要：An estimated 23 million people live on floodplains affected by potentially dangerous concentrations of toxic waste derived from past and present metal mining activity. We analyzed the global dimensions of this hazard, particularly in regard to lead, zinc, copper, and arsenic, using a georeferenced global database detailing all known metal mining sites and intact and failed tailings storage facilities. We then used process-based and empirically tested modeling to produce a global assessment of ...
• Criticism builds against Ph.D. careers firm Cheeky Scientist AI翻译
  作者：Offord, Catherine
  摘要：Researchers say they felt pushed into signing away thousands of dollars for services they ultimately didn't want
• Accurate proteome-wide missense variant effect prediction with AlphaMissense AI翻译
  作者：Cheng, Jun; Novati, Guido; Pan, Joshua; Bycroft, Clare; Zemgulyte, Akvile; Applebaum, Taylor; Pritzel, Alexander; Wong, Lai Hong; Zielinski, Michal; Sargeant, Tobias; Schneider, Rosalia G.; Senior, Andrew W.; Jumper, John; Hassabis, Demis; Kohli, Pushmeet; Avsec, Ziga
  作者单位：Alphabet Inc.; DeepMind; Google Incorporated
  摘要：The vast majority of missense variants observed in the human genome are of unknown clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on human and primate variant population frequency databases to predict missense variant pathogenicity. By combining structural context and evolutionary conservation, our model achieves state-of-the-art results across a wide range of genetic and experimental benchmarks, all without explicitly training on such data. The average ...
• Lady Sapiens: Breaking Stereotypes About Prehistoric Women AI翻译
  作者：Harris, Katie
• South Korea, a science spending champion, proposes cutbacks AI翻译
  作者：Normile, Dennis
  摘要：Sudden revamp would trim basic research spending while boosting biomedical innovation, space, and other fields
• DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans AI翻译
  作者：Xia, Yisui; Sonneville, Remi; Jenkyn-Bedford, Michael; Ji, Liqin; Alabert, Constance; Hong, Ye; Yeeles, Joseph T. P.; Labib, Karim P. M.
  作者单位：University of Dundee; MRC Laboratory Molecular Biology; Shandong University; University of Dundee; Shenzhen University; Rockefeller University
  摘要：Assembly of the CMG (CDC-45-MCM-2-7-GINS) helicase is the key regulated step during eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require additional factors that are not present in yeast. In this work, we show that Caenorhabditis elegans DNSN-1, the ortholog of human DONSON, functions during helicase assembly in a complex with MUS-101/TOPBP1. DNSN-1 is required to recruit the GINS complex to chromatin, and a cryo-electron microscopy structure indicates that D...
• How mothers tolerate their children AI翻译
  作者：Porrett, Paige M.
  作者单位：University of Alabama System; University of Alabama Birmingham
  摘要：When pregnant, maternal immunologic tolerance is required to ensure that the fetus is not rejected by the mother's immune system. This tolerance is achieved by expansion of a subset of CD4(+) T cells with regulatory properties (T-reg cells) that protect against fetal loss (1-3). Maternal T-reg cells develop immunologic memory, which confers fetal-specific protection against complications in subsequent pregnancy (4). Prior studies have suggested that memory T-reg cells are sustained by fetal mi...