Science

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• Autoregulated splicing of TRA2β programs T cell fate in response to antigen-receptor stimulation AI翻译
  作者：Karginov, Timofey A.; Menoret, Antoine; Leclair, Nathan K.; Harrison, Andrew G.; Chandiran, Karthik; Suarez-Ramirez, Jenny E.; Yurieva, Marina; Karlinsey, Keaton; Wang, Penghua; O'Neill, Rachel J.; Murphy, Patrick A.; Adler, Adam J.; Cauley, Linda S.; Anczukow, Olga; Zhou, Beiyan; Vella, Anthony T.
  作者单位：University of Connecticut; University of Connecticut; Jackson Laboratory; University of Connecticut; University of Connecticut; University of Connecticut
  摘要：T cell receptor (TCR) sensitivity to peptide-major histocompatibility complex (MHC) dictates T cell fate. Canonical models of TCR sensitivity cannot be fully explained by transcriptional regulation. In this work, we identify a posttranscriptional regulatory mechanism of TCR sensitivity that guides alternative splicing of TCR signaling transcripts through an evolutionarily ultraconserved poison exon (PE) in the RNA-binding protein (RBP) TRA2 beta in mouse and human. TRA2 beta-PE splicing, seen ...
• Hope for Cynics: The Surprising Science of Human Goodness AI翻译
  作者：Shinbrot, Xoco A.
• Farmed fur animals carry harmful viruses AI翻译
  作者：Brainard, Jeffery
• Farmed fur animals carry harmful viruses AI翻译
  作者：Brainard, Jeffrey
• Einstein's Tutor: The Story of Emmy Noether and the Invention of Modern Physics AI翻译
  作者：Dewey, Sarah; Phillips, Lee
• Insulating electromagnetic-shielding silicone compound enables direct potting electronics AI翻译
  作者：Zhou, Xinfeng; Min, Peng; Liu, Yue; Jin, Meng; Yu, Zhong-Zhen; Zhang, Hao-Bin
  作者单位：Beijing University of Chemical Technology; Beijing University of Chemical Technology
  摘要：Traditional electromagnetic interference-shielding materials are predominantly electrically conductive, posing short-circuit risks when applied in highly integrated electronics. To overcome this dilemma, we propose a microcapacitor-structure model comprising conductive fillers as polar plates and intermediate polymer as a dielectric layer to develop insulating electromagnetic interference-shielding polymer composites. The electron oscillation in plates and dipole polarization in dielectric lay...
• Generative AI as a tool for truth AI翻译
  作者：Bago, Bence; Bonnefon, Jean-Francois
  作者单位：Tilburg University; Universite de Toulouse; Universite Toulouse 1 Capitole; Toulouse School of Economics
  摘要：Conversation with a trained chatbot can reduce conspiratorial beliefs
• Characterization of a Lewis adduct in its inner and outer forms AI翻译
  作者：Liu, Wei-Chun; Gabbai, Francois P.
  作者单位：Texas A&M University System; Texas A&M University College Station
  摘要：The entrance channel of bimolecular reactions sometimes involves the formation of outer complexes as weakly bound, fleeting intermediates. Here, we characterize such an outer complex in a system that models the bimolecular, C-O bond-forming reaction of a phosphine oxide Lewis base with a carbenium Lewis acid. Crystallographic studies show that the C-O distance in the outer form exceeds that of the final or inner adduct by 1.1 angstroms. As the system samples the two forms of the complex, which...
• No 'collapse' for ancient people on Rapa Nui AI翻译
  作者：Ortega, Rodrigo Perez
  摘要：New genomic, archaeological evidence counters influential tale of ecological suicide
• Linguaphile: A Life of Language Love AI翻译
  作者：Simpkins, Carolyn Wong; Sedivy, Julie