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作者：McPherson, Rebecca Adam; Wekerle, Claudia; Kanzow, Torsten; Ionita, Monica; Heukamp, Finn Ole; Zeising, Ole; Humbert, Angelika
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Bremen; Stefan cel Mare University of Suceava; University of Bremen
摘要：Mass loss from the Greenland ice sheet has contributed to global sea-level rise over the past 20 years. Yet direct observations from the 79 North Glacier (79NG) calving front reveal decreasing Atlantic Intermediate Water (AIW) temperatures below the ice tongue from 2018 to 2021, leading to reduced ocean heat transport. This is linked to a concurrent decrease in basal melt and thinning rates at the grounding line. The origin of this AIW cooling is traced to a slowdown of the large-scale ocean c...
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作者：Ryan-Anderson, C.; Brown, N. C.; Baldwin, C. H.; Dreiling, J. M.; Foltz, C.; Gaebler, J. P.; Gatterman, T. M.; Hewitt, N.; Holliman, C.; Horst, C. V.; Johansen, J.; Lucchetti, D.; Mengle, T.; Matheny, M.; Matsuoka, Y.; Mayer, K.; Mills, M.; Moses, S. A.; Neyenhuis, B.; Pino, J.; Siegfried, P.; Stutz, R. P.; Walker, J.; Hayes, D.
摘要：Quantum state teleportation is commonly used in designs for large-scale quantum computers. Using Quantinuum's H2 trapped-ion quantum processor, we demonstrate fault-tolerant state teleportation circuits for a quantum error correction code-specifically the Steane code. The circuits use up to 30 qubits at the physical level and employ real-time quantum error correction. We conducted experiments on several variations of logical teleportation circuits using both transversal gates and lattice surge...
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作者：Zhao, Jiantao; Yu, Huacheng; Jin, Xingchen; Qin, Bo; Mei, Shan; Xu, Jiang-Fei; Zhang, Xi
作者单位：Tsinghua University
摘要：Click reactions, which are characterized by rapid, high-yielding, and highly selective coupling of two reaction partners, are powerful tools in synthesis but are rarely reversible. Innovative strategies that reverse such couplings in a precise and on-demand manner, enabling a click-clip sequence, would greatly expand the technique's versatility. Herein, a click and clip reaction pair is demonstrated by manipulation of a sulfilimine linkage. Phenothiazines and amines are rapidly and quantitativ...
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作者：Lynteris, Christos
作者单位：University of St Andrews
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作者：Aso, Yoichi
作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ)
摘要：The detection of ripples in spacetime, which are known as gravitational waves (GWs), has emerged as a critical frontier in modern astrophysics. Indeed, kilometer-scale detectors, such as the Laser Interferometer Gravitational-Wave Observatory (LIGO), have provided insights into energetic astronomical events, including the mergers of black holes and neutron stars. It is remarkable that the sensitivity of such large detectors is limited by quantum-mechanical fluctuations, which usually become re...
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作者：Keesing, Felicia; Ostfeld, Richard S.
作者单位：Cary Institute of Ecosystem Studies
摘要：Rodents are ubiquitous and typically unwelcome dwellers in human habitats worldwide, infesting homes, farm fields, and agricultural stores and potentially shedding disease-causing microbes into the most human-occupied of spaces. Of the vertebrate animal taxa that share pathogens with us, rodents are the most abundant and diverse, with hundreds of species of confirmed zoonotic hosts, some of which have nearly global distributions. However, only 12% of rodent species are known to be sources of p...
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作者：Popow, Johannes; Farnaby, William; Gollner, Andreas; Kofink, Christiane; Fischer, Gerhard; Wurm, Melanie; Zollman, David; Wijaya, Andre; Mischerikow, Nikolai; Hasenoehrl, Carina; Prokofeva, Polina; Arnhof, Heribert; Arce-Solano, Silvia; Bell, Sammy; Boeck, Georg; Diers, Emelyne; Frost, Aileen B.; Goodwin-Tindall, Jake; Karolyi-Oezguer, Jale; Khan, Shakil; Klawatsch, Theresa; Koegl, Manfred; Kousek, Roland; Kratochvil, Barbara; Kropatsch, Katrin; Lauber, Arnel A.; Mclennan, Ross; Olt, Sabine; Peter, Daniel; Petermann, Oliver; Roessler, Vanessa; Stolt-Bergner, Peggy; Strack, Patrick; Strauss, Eva; Trainor, Nicole; Vetma, Vesna; Whitworth, Claire; Zhong, Siying; Quant, Jens; Weinstabl, Harald; Kuster, Bernhard; Ettmayer, Peter; Ciulli, Alessio
作者单位：Boehringer Ingelheim; University of Dundee; University of Dundee; Technical University of Munich; Boehringer Ingelheim
摘要：Mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) protein are highly prevalent in cancer. However, small-molecule concepts that address oncogenic KRAS alleles remain elusive beyond replacing glycine at position 12 with cysteine (G12C), which is clinically drugged through covalent inhibitors. Guided by biophysical and structural studies of ternary complexes, we designed a heterobifunctional small molecule that potently degrades 13 out of 17 of the most prevalent oncogenic KRAS ...
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作者：Brainard, Jeffrey; Servick, Kelly
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作者：Ash, Caroline; Lopez, Bianca; Vignieri, Sacha; Wible, Brad
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作者：Simkovic IV, Fedor; Rossi, Riccardo; Georges, Antoine; Ferrero, Michel
作者单位：Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Universite PSL; College de France; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Simons Foundation; Flatiron Institute; University of Geneva
摘要：The relationship between the pseudogap and underlying ground-state phases has not yet been rigorously established. We investigated the doped two-dimensional Hubbard model at finite temperature using controlled diagrammatic Monte Carlo calculations, allowing for the computation of spectral properties in the infinite-size limit and with arbitrary momentum resolution. We found three distinct regimes as a function of doping and interaction strength: a weakly correlated metal, a correlated metal wi...
