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作者：Lim, Fabian; Solvason, Joe J.; Ryan, Genevieve E.; Le, Sophia H.; Jindal, Granton A.; Steffen, Paige; Jandu, Simran K.; Farley, Emma K.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Enhancers control the location and timing of gene expression and contain the majority of variants associated with disease1-3. The ZRS is arguably the most well-studied vertebrate enhancer and mediates the expression of Shh in the developing limb4. Thirty-one human single-nucleotide variants (SNVs) within the ZRS are associated with polydactyly4-6. However, how this enhancer encodes tissue-specific activity, and the mechanisms by which SNVs alter the number of digits, are poorly understood. Her...
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作者：Liu, Dasheng; Thompson, Julian R.; Gao, Jun; Shen, Henglun
作者单位：University of London; University College London; Nanjing Institute of Environmental Sciences, Ministry of Ecology & Environment; Zaozhuang University
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作者：Sukenikova, L.; Mallone, A.; Schreiner, B.; Ripellino, P.; Nilsson, J.; Stoffel, M.; Ulbrich, S. E.; Sallusto, F.; Latorre, D.
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University Zurich Hospital; University of Zurich; Universita della Svizzera Italiana; University of Zurich; University Zurich Hospital; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Universita della Svizzera Italiana
摘要：Guillain-Barre syndrome (GBS) is a rare heterogenous disorder of the peripheral nervous system, which is usually triggered by a preceding infection, and causes a potentially life-threatening progressive muscle weakness1. Although GBS is considered an autoimmune disease, the mechanisms that underlie its distinct clinical subtypes remain largely unknown. Here, by combining in vitro T cell screening, single-cell RNA sequencing and T cell receptor (TCR) sequencing, we identify autoreactive memory ...
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作者：Carson, Cathryn
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
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作者：Hughes, Brent B.; Beheshti, Kathryn M.; Tinker, M. Tim; Angelini, Christine; Endris, Charlie; Murai, Lee; Anderson, Sean C.; Espinosa, Sarah; Staedler, Michelle; Tomoleoni, Joseph A.; Sanchez, Madeline; Silliman, Brian R.
作者单位：California State University System; Sonoma State University; Duke University; University of California System; University of California Santa Cruz; University of California System; University of California Santa Barbara; State University System of Florida; University of Florida; Moss Landing Marine Laboratories; Fisheries & Oceans Canada; Simon Fraser University; Monterey Bay Aquarium Research Institute; United States Department of the Interior; United States Geological Survey
摘要：The recovery of top predators is thought to have cascading effects on vegetated ecosystems and their geomorphology1,2, but the evidence for this remains correlational and intensely debated3,4. Here we combine observational and experimental data to reveal that recolonization of sea otters in a US estuary generates a trophic cascade that facilitates coastal wetland plant biomass and suppresses the erosion of marsh edges-a process that otherwise leads to the severe loss of habitats and ecosystem ...
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作者：[Anonymous]
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作者：Gibney, Elizabeth
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作者：Ferretti, Luca; Wymant, Chris; Petrie, James; Tsallis, Daphne; Kendall, Michelle; Ledda, Alice; Di Lauro, Francesco; Fowler, Adam; Di Francia, Andrea; Panovska-Griffiths, Jasmina; Abeler-Doerner, Lucie; Charalambides, Marcos; Briers, Mark; Fraser, Christophe
作者单位：University of Oxford; University of Oxford; University of Warwick; UK Health Security Agency (UKHSA); Alan Turing Institute
摘要：How likely is it to become infected by SARS-CoV-2 after being exposed? Almost everyone wondered about this question during the COVID-19 pandemic. Contact-tracing apps1,2 recorded measurements of proximity3 and duration between nearby smartphones. Contacts-individuals exposed to confirmed cases-were notified according to public health policies such as the 2 m, 15 min guideline4,5, despite limited evidence supporting this threshold. Here we analysed 7 million contacts notified by the National He...
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作者：Kozlov, Max
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作者：Sukenikova, L.; Mallone, A.; Schreiner, B.; Ripellino, P.; Nilsson, J.; Stoffel, M.; Ulbrich, S. E.; Sallusto, F.; Latorre, D.
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University Zurich Hospital; University of Zurich; Universita della Svizzera Italiana; University of Zurich; University Zurich Hospital; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Geneva; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Universita della Svizzera Italiana
摘要：Guillain-Barre syndrome (GBS) is a rare heterogenous disorder of the peripheral nervous system, which is usually triggered by a preceding infection, and causes a potentially life-threatening progressive muscle weakness1. Although GBS is considered an autoimmune disease, the mechanisms that underlie its distinct clinical subtypes remain largely unknown. Here, by combining in vitro T cell screening, single-cell RNA sequencing and T cell receptor (TCR) sequencing, we identify autoreactive memory ...
