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作者：Courellis, Hristos S.; Minxha, Juri; Cardenas, Araceli R.; Kimmel, Daniel L.; Reed, Chrystal M.; Valiante, Taufik A.; Salzman, C. Daniel; Mamelak, Adam N.; Fusi, Stefano; Rutishauser, Ueli
作者单位：Cedars Sinai Medical Center; California Institute of Technology; Columbia University; Krembil Research Institute; University of Toronto; University Health Network Toronto; University of Toronto; University Health Network Toronto; Columbia University; Cedars Sinai Medical Center; New York State Psychiatry Institute; Columbia University; Columbia University; Cedars Sinai Medical Center
摘要：Humans have the remarkable cognitive capacity to rapidly adapt to changing environments. Central to this capacity is the ability to form high-level, abstract representations that take advantage of regularities in the world to support generalization1. However, little is known about how these representations are encoded in populations of neurons, how they emerge through learning and how they relate to behaviour2,3. Here we characterized the representational geometry of populations of neurons (si...
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作者：Plackett, Benjamin
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作者：Gogoi, Mayuri; Clark, Paula A.; Ferreira, Ana C. F.; Rodriguez Rodriguez, Noe; Heycock, Morgan; Ko, Michelle; Murphy, Jane E.; Chen, Victor; Luan, Shi-Lu; Jolin, Helen E.; McKenzie, Andrew N. J.
作者单位：MRC Laboratory Molecular Biology
摘要：Migration and homing of immune cells are critical for immune surveillance. Trafficking is mediated by combinations of adhesion and chemokine receptors that guide immune cells, in response to chemokine signals, to specific locations within tissues and the lymphatic system to support tissue-localized immune reactions and systemic immunity(1,2). Here we show that disruption of leukaemia inhibitory factor (LIF) production from group2 innate lymphoid cells (ILC2s) prevents immune cells leaving the ...
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作者：Hoeijmakers, Jan H. J.
作者单位：Erasmus University Rotterdam; Erasmus MC
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作者：Mallapaty, Smriti
摘要：Researchers from Afghanistan who found sanctuary around the world following the Taliban takeover in 2021 are struggling to settle in.
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作者：Newsome, Melba
摘要：Many nations have embraced burning wood pellets to produce electricity - under the assumption that it is carbon neutral. But research shows this approach can boost greenhouse-gas emissions and threaten the health of local communities.
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作者：Tan, Jiaxin; Xiao, Yuan; Kong, Fang; Zhang, Xiaochun; Xu, Hanwen; Zhu, Angqi; Liu, Yiming; Lei, Jianlin; Tian, Boxue; Yuan, Yafei; Yan, Chuangye
作者单位：Tsinghua University; Tsinghua University
摘要：Noradrenaline, also known as norepinephrine, has a wide range of activities and effects on most brain cell types1. Its reuptake from the synaptic cleft heavily relies on the noradrenaline transporter (NET) located in the presynaptic membrane2. Here we report the cryo-electron microscopy (cryo-EM) structures of the human NET in both its apo state and when bound to substrates or antidepressant drugs, with resolutions ranging from 2.5 & Aring; to 3.5 & Aring;. The two substrates, noradrenaline an...
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作者：Gibney, Elizabeth
摘要：Artificial-intelligence developers are buying access to valuable data sets that contain research papers - raising uncomfortable questions about copyright.
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作者：Lenharo, Mariana
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作者：Madani, Navid
作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School
摘要：In this traumatized region, exploring a rich history of scientific and medical problem-solving provides the context to imagine a better future.
