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• Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction AI翻译
  作者：Oosterlaken, Mathieu; Rogliardo, Angelina; Lipina, Tatiana; Lafon, Pierre-Andre; Tsitokana, Mireille Elodie; Keck, Mathilde; Cahuzac, Heloise; Prieu-Serandon, Pierre; Diem, Severine; Derieux, Cecile; Camberlin, Celia; Lafont, Chrystel; Meyer, Damien; Chames, Patrick; Vandermoere, Franck; Marin, Philippe; Prezeau, Laurent; Servent, Denis; Salahpour, Ali; Ramsey, Amy J.; Becamel, Carine; Pin, Jean-Philippe; Kniazeff, Julie; Rondard, Philippe
  作者单位：Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); University of Toronto; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Institut Paoli-Calmette (IPC); Universite de Montpellier; Ecole nationale superieure de chimie de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：There is an urgent need for efficient and innovative therapies to treat brain disorders such as psychiatric and neurodegenerative diseases. Immunotherapies have proved to be efficient in many medical areas, but have not been considered to treat brain diseases due to the poor brain penetration of immunoglobulins1,2. Here we developed a bivalent biparatopic antibody, made of two camelid heavy-chain antibodies (called nanobodies)3, one binding to, and the other potentiating the activity of, homod...
• US Supreme Court allows NIH to cut $2 billion in research grants AI翻译
  作者：Garisto, Dan; Kozlov, Max
• Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics AI翻译
  作者：Tortorici, M. Alejandra; Choi, Annette; Gibson, Cecily A.; Lee, Jimin; Brown, Jack T.; Stewart, Cameron; Joshi, Anshu; Harari, Sheri; Willoughby, Isabelle; Treichel, Catherine; Leaf, Elizabeth M.; Bloom, Jesse D.; King, Neil P.; Tait-Burkard, Christine; Whittaker, Gary R.; Veesler, David
  作者单位：University of Washington; University of Washington Seattle; Cornell University; Howard Hughes Medical Institute; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Edinburgh; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; Cornell University; Cornell University
  摘要：The ability of coronaviruses to recombine and cross species barriers affects human and animal health globally and is a pandemic threat1,2. FCoV-23 is a recently emerged, highly pathogenic recombinant coronavirus responsible for a widespread outbreak of feline infectious peritonitis. Here we report cryogenic electron microscopy structures of two FCoV-23 spike isoforms that correspond to the in-host loss of domain 0 observed in clinical samples. The loss of domain 0 markedly enhances the fusogen...
• Complete biosynthesis of salicylic acid from phenylalanine in plants AI翻译
  作者：Zhu, Bao; Zhang, Yanjun; Gao, Rong; Wu, Zhihua; Zhang, Wei; Zhang, Chao; Zhang, Penghong; Ye, Can; Yao, Linbo; Jin, Ying; Mao, Hui; Tou, Peiyao; Huang, Peng; Zhao, Jiangzhe; Zhao, Qiao; Liu, Chang-Jun; Zhang, Kewei
  作者单位：Zhejiang Normal University; Zhejiang Normal University; Zhejiang Normal University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; United States Department of Energy (DOE); Brookhaven National Laboratory
  摘要：Salicylic acid (SA) is a pivotal phytohormone for plant responses to biotic and abiotic stresses. Plants have evolved two pathways to produce SA: the isochorismate synthase and phenylalanine ammonia lyase (PAL) pathways1. Whereas the isochorismate synthase pathway has been fully identified2, 3-4, the PAL pathway remains incomplete. Here we report the full characterization of the PAL pathway for SA biosynthesis via functional analysis of rice (Oryza sativa) SA-DEFICIENT GENE 1 (OSD1) to OSD4. T...
• How to work with 'big tech' AI翻译
  作者：Currall, Steven C.
  作者单位：Harvard University
• The brain's map of the body is surprisingly stable - even after a limb is lost AI翻译
  作者：Kavanagh, Katie
• Ultrabroadband on-chip photonics for full-spectrum wireless communications AI翻译
  作者：Tao, Zihan; Wang, Haoyu; Feng, Hanke; Guo, Yijun; Shen, Bitao; Sun, Dan; Tao, Yuansheng; Han, Changhao; He, Yandong; Bowers, John E.; Shu, Haowen; Wang, Cheng; Wang, Xingjun
  作者单位：Peking University; City University of Hong Kong; Peking University; University of California System; University of California Santa Barbara; Peking University; Peking University
  摘要：The forthcoming sixth-generation and beyond wireless networks are poised to operate across an expansive frequency range-from microwave, millimetre wave to terahertz bands-to support ubiquitous connectivity in diverse application scenarios1, 2-3. This necessitates a one-size-fits-all hardware solution that can be adaptively reconfigured within this wide spectrum to support full-band coverage and dynamic spectrum management4. However, existing electrical or photonic-assisted solutions face a lot...
• Brain-wide representations of prior information in mouse decision-making AI翻译
  作者：Findling, Charles; Hubert, Felix; Acerbi, Luigi; Benson, Brandon; Benson, Julius; Birman, Daniel; Bonacchi, Niccolo; Buchanan, E. Kelly; Bruijns, Sebastian; Carandini, Matteo; Catarino, Joana A.; Chapuis, Gaelle A.; Churchland, Anne K.; Dan, Yang; Davatolhagh, Felicia; Dewitt, Eric E. J.; Engel, Tatiana A.; Fabbri, Michele; Faulkner, Mayo A.; Fiete, Ila Rani; Freitas-Silva, Laura; Gercek, Berk; Harris, Kenneth D.; Hausser, Michael; Hofer, Sonja B.; Hu, Fei; Huntenburg, Julia M.; Khanal, Anup; Krasniak, Chris; Langdon, Christopher; Langfield, Christopher A.; Latham, Peter E.; Lau, Petrina Y. P.; Mainen, Zach; Meijer, Guido T.; Miska, Nathaniel J.; Mrsic-Flogel, Thomas D.; Noel, Jean-Paul; Nylund, Kai; Pan-Vazquez, Alejandro; Paninski, Liam; Pillow, Jonathan; Rossant, Cyrille; Roth, Noam; Schaeffer, Rylan; Schartner, Michael; Shi, Yanliang; Socha, Karolina Z.; Steinmetz, Nicholas A.; Svoboda, Karel; Tessereau, Charline; Urai, Anne E.; Wells, Miles J.; West, Steven Jon; Whiteway, Matthew R.; Winter, Olivier; Witten, Ilana B.; Zador, Anthony; Zhang, Yizi; Dayan, Peter; Pouget, Alexandre
  作者单位：University of Geneva; University of Helsinki; Stanford University; New York University; University of Washington; University of Washington Seattle; Instituto Universitario de Lisboa; Eberhard Karls University of Tubingen; Max Planck Society; University of London; University College London; Fundacao Champalimaud; University of California System; University of California Los Angeles; University of California System; University of California Berkeley; Princeton University; Massachusetts Institute of Technology (MIT); University of Hong Kong; University of London; University College London; Cold Spring Harbor Laboratory; Columbia University; University of London; University College London; University of Minnesota System; University of Minnesota Twin Cities; Leiden University - Excl LUMC; Leiden University
  摘要：The neural representations of prior information about the state of the world are poorly understood1. Here, to investigate them, we examined brain-wide Neuropixels recordings and widefield calcium imaging collected by the International Brain Laboratory. Mice were trained to indicate the location of a visual grating stimulus, which appeared on the left or right with a prior probability alternating between 0.2 and 0.8 in blocks of variable length. We found that mice estimate this prior probabilit...
• Marsquakes indicate that the inner core of the red planet is solid, not liquid AI翻译
  作者：Schmerr, Nicholas C.
  作者单位：University System of Maryland; University of Maryland College Park
• Missing steps uncovered in a pathway plants use to produce the defence molecule salicylic acid AI翻译
  作者：Hyun, Jiyeon; Yoo, Heejin
  作者单位：Utah System of Higher Education; University of Utah