Nature

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• Topological segregation of stress sensors along the gut crypt-villus axis AI翻译
  作者：Touhara, Kouki K.; Rossen, Nathan D.; Deng, Fei; Castro, Joel; Harrington, Andrea M.; Chu, Tifany; Garcia-Caraballo, Sonia; Brizuela, Mariana; O'Donnell, Tracey; Xu, Jinhao; Cil, Onur; Brierley, Stuart M.; Li, Yulong; Julius, David
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Peking University; South Australian Health & Medical Research Institute (SAHMRI); University of Adelaide; University of California System; University of California San Francisco
  摘要：The crypt-villus structure of the small intestine serves as an essential protective barrier. The integrity of this barrier is monitored by the complex sensory system of the gut, in which serotonergic enterochromaffin (EC) cells play an important part1,2. These rare sensory epithelial cells surveil the mucosal environment for luminal stimuli and transmit signals both within and outside the gut3, 4, 5-6. However, whether EC cells in crypts and villi detect different stimuli or produce distinct p...
• Meet the researchers pioneering Spanish climate solutions AI翻译
  作者：Forrester, Nikki
• The future of Alzheimer's treatment AI翻译
  作者：Makin, Simon
• What makes us human? Milestone ape genomes promise clues AI翻译
  作者：Basilio, Humberto
• Africa CDC must become financially independent AI翻译
  作者：Evaborhene, Nelson Aghogho; Oga, Jessica; Udokanma, Echezona
  作者单位：University of Witwatersrand; Coventry University
• Obesity-drug pioneers and 13,508 physicists win US$3-million Breakthrough Prizes AI翻译
  作者：Merali, Zeeya
• mental-health crisis plagues PhDs - these evidence-led initiatives offer help AI翻译
  作者：Schwaller, Fred
• Bovine H5N1 binds poorly to human-type sialic acid receptors reply AI翻译
  作者：Eisfeld, Amie J.; Biswas, Asim; Guan, Lizheng; Gu, Chunyang; Maemura, Tadashi; Trifkovic, Sanja; Wang, Tong; Babujee, Lavanya; Dahn, Randall; Halfmann, Peter J.; Barnhardt, Tera; Neumann, Gabriele; Suzuki, Yasuo; Thompson, Alexis; Swinford, Amy K.; Dimitrov, Kiril M.; Poulsen, Keith; Kawaoka, Yoshihiro
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Shizuoka; Texas A&M University System; Texas A&M University College Station; University of Wisconsin System; University of Wisconsin Madison; University of Tokyo; University of Tokyo; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan
• Controlled patterning of crystalline domains by frontal polymerization (vol 634, pg 85, 2024) AI翻译
  作者：Paul, Justine E.; Gao, Yuan; Go, Yoo Kyung; Koett, Luis E. Rodriguez; Sharma, Anisha; Chen, Manxin; Lessard, Jacob J.; Topkaya, Tolga; Leal, Cecilia; Moore, Jeffrey S.; Geubelle, Philippe H.; Sottos, Nancy R.
• Chanoclavine synthase operates by an NADPH-independent superoxide mechanism AI翻译
  作者：Chen, Chun-Chi; Yu, Zhi-Pu; Liu, Ziwei; Yao, Yongpeng; Hagedoorn, Peter-Leon; Schmitz, Rob Alexander; Yang, Lujia; Yu, Lu; Liu, Aokun; Sheng, Xiang; Su, Hao; Ma, Yaqing; Wang, Te; Huang, Jian-Wen; Zhang, Lilan; Yan, Juzhang; Bao, Jinping; Cui, Chengsen; Li, Xian; Shen, Panpan; Zhang, Wuyuan; Min, Jian; Wang, Chang-Yun; Guo, Rey-Ting; Gao, Shu-Shan
  作者单位：Hangzhou Normal University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Hubei Hongshan Laboratory; Hubei University; Ocean University of China; Ocean University of China; Chinese Academy of Sciences; Institute of Microbiology, CAS; Delft University of Technology; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS
  摘要：More than ten ergot alkaloids comprising both natural and semi-synthetic products are used to treat various diseases1,2. The central C ring forms the core pharmacophore for ergot alkaloids, giving them structural similarity to neurotransmitters, thus enabling their modulation of neurotransmitter receptors3. The haem catalase chanoclavine synthase (EasC) catalyses the construction of this ring through complex radical oxidative cyclization4. Unlike canonical catalases, which catalyse H2O2 dispro...