作者：Perelli, Luigi; Zhang, Li; Mangiameli, Sarah; Giannese, Francesca; Mahadevan, Krishnan K.; Peng, Fuduan; Citron, Francesca; Khan, Hania; Le, Courtney; Gurreri, Enrico; Carbone, Federica; Russell, Andrew J. C.; Soeung, Melinda; Lam, Truong Nguyen Anh; Lundgren, Sebastian; Marisetty, Sujay; Zhu, Cihui; Catania, Desiree; Mohamed, Alaa M. T.; Feng, Ningping; Augustine, Jithesh Jose; Sgambato, Alessandro; Tortora, Giampaolo; Draetta, Giulio F.; Tonon, Giovanni; Futreal, Andrew; Giuliani, Virginia; Carugo, Alessandro; Viale, Andrea; Kim, Michael P.; Heffernan, Timothy P.; Wang, Linghua; Kalluri, Raghu; Cittaro, Davide; Chen, Fei; Genovese, Giannicola
作者单位：University of Texas System; UTMD Anderson Cancer Center; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Nerviano Medical Sciences S.r.l; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Merck & Company; Merck & Company Italy; University of Texas System; UTMD Anderson Cancer Center; Rice University; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center
摘要：Mesenchymal plasticity has been extensively described in advanced epithelial cancers; however, its functional role in malignant progression is controversial1, 2, 3, 4-5. The function of epithelial-to-mesenchymal transition (EMT) and cell plasticity in tumour heterogeneity and clonal evolution is poorly understood. Here we clarify the contribution of EMT to malignant progression in pancreatic cancer. We used somatic mosaic genome engineering technologies to trace and ablate malignant mesenchyma...
作者：Joaquin, Jeremiah Joven; Biana, Hazel T.
作者单位：De La Salle University
作者：Rescigno, Maria; Toffano, Alberto; Ranieri, Umbertoluca; Andriambariarijaona, Leon; Gaal, Richard; Klotz, Stefan; Koza, Michael Marek; Ollivier, Jacques; Martelli, Fausto; Russo, John; Sciortino, Francesco; Teixeira, Jose; Bove, Livia Eleonora
作者单位：Sapienza University Rome; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Bristol; University of Edinburgh; University of Edinburgh; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Sorbonne Universite; CNRS - Institute of Physics (INP); Institut Laue-Langevin (ILL); University of Manchester; CEA; Centre National de la Recherche Scientifique (CNRS); University of Basque Country
摘要：Water is the third most abundant molecule in the universe and a key component in the interiors of icy moons, giant planets and Uranus- and Neptune-like exoplanets1, 2-3. Owing to its distinct molecular structure and flexible hydrogen bonds that readily adapt to a wide range of pressures and temperatures, water forms numerous crystalline and amorphous phases4, 5-6. Most relevant for the high pressures and temperatures of planetary interiors is ice VII (ref. 4), and simulations have identified a...
作者：Athukoralage, Januka S.; McMahon, Stephen A.; Zhang, Changyi; Grueschow, Sabine; Graham, Shirley; Krupovic, Mart; Whitaker, Rachel J.; Gloster, Tracey M.; White, Malcolm F.
作者单位：University of St Andrews; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
