8093期

最新文章

• Thiorphan reprograms neurons to promote functional recovery after spinal cord injury AI翻译
  作者：van Niekerk, E. A.; de Freria, C. Marques; Mancarci, B. O.; Groeniger, K.; Kulinich, D.; Riley, T.; Kawaguchi, R.; Okawa, S.; Vokes, T.; Rosenzweig, E. S.; Sinopoulou, E.; Castle, M. J.; Huie, R.; Ferguson, A. R.; Kfoury-Beaumont, N.; Khalessi, A.; Pavlidis, P.; Tuszynski, M. H.
  作者单位：University of California System; University of California San Diego; University of British Columbia; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California San Francisco; US Department of Veterans Affairs; Veterans Health Administration (VHA); San Francisco VA Medical Center; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA)
  摘要：We previously identified an embryonic shift in the corticospinal motor neuronal transcriptome after spinal cord injury associated with successful axonal regeneration(1). Exploiting this transcriptional regenerative 'signature', here we used in silico screens to identify small molecules that generate similar shifts in the transcriptome, and identified thiorphan-a neutral endopeptidase inhibitor-as a lead candidate. In a new adult motor cortex neuronal in vitro screen(2), thiorphan increased neu...
• Mapping Plasmodium transitions and interactions in the Anopheles female AI翻译
  作者：Yan, Yan; Verzier, Lisa H.; Cheung, Elaine; Appetecchia, Federico; March, Sandra; Craven, Ailsa R.; Du, Esrah; Probst, Alexandra S.; Rinvee, Tasneem A.; de Vries, Laura E.; Kauffman, Jamie; Bhatia, Sangeeta N.; Nelson, Elisabeth; Singh, Naresh; Peng, Duo; Shaw, W. Robert; Catteruccia, Flaminia
  作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Chan Zuckerberg Initiative (CZI); Howard Hughes Medical Institute
  摘要：The human malaria parasite, Plasmodium falciparum, relies exclusively on Anopheles mosquitoes for transmission. Once ingested during blood feeding, most parasites die in the mosquito midgut lumen or during epithelium traversal1. How surviving ookinetes interact with midgut cells and form oocysts remains poorly understood, yet these steps are essential to initiate a remarkable growth process culminating in the production of thousands of infectious sporozoites2. Here, using single-cell RNA seque...
• The pancreatic cancer models helping to drive innovation in the field AI翻译
  作者：Nuwer, Rachel
• Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury ( vol 618 , pg 1072 , 2023) AI翻译
  作者：Kayagaki, Nobuhiko; Stowe, Irma B.; Alegre, Kamela; Deshpande, Ishan; Wu, Shuang; Lin, Zhonghua; Kornfeld, Opher S.; Lee, Bettina L.; Zhang, Juan; Liu, John; Suto, Eric; Lee, Wyne P.; Schneider, Kellen; Lin, WeiYu; Seshasayee, Dhaya; Bhangale, Tushar; Chalouni, Cecile; Johnson, Matthew C.; Joshi, Prajakta; Mossemann, Jan; Zhao, Sarah; Ali, Danish; Goldenberg, Neil M.; Sayed, Blayne A.; Steinberg, Benjamin E.; Newton, Kim; Webster, Joshua D.; Kelly, Ryan L.; Dixit, Vishva M.
• Two residues reprogram immunity receptors for nitrogen-fixing symbiosis AI翻译
  作者：Tsitsikli, Magdalini; Simonsen, Bine; Luu, Thi-Bich; Larsen, Maria M.; Andersen, Camilla G.; Gysel, Kira; Lironi, Damiano; Kronauer, Christina; Rubsam, Henriette; Hansen, Simon B.; Baerentsen, Rene; Wulff, Jesper Lundsgaard; Johansen, Sarah Holt; Sezer, Gulendam; Stougaard, Jens; Andersen, Kasper Rojkjaer; Radutoiu, Simona
  作者单位：Aarhus University; University of Freiburg; Aarhus University; University of Zurich
  摘要：Receptor signalling determines cellular responses and is crucial for defining specific biological outcomes. In legume root cells, highly similar and structurally conserved chitin and Nod factor receptor kinases activate immune or symbiotic pathways, respectively, when chitinous ligands are perceived1. Here we show that specific amino acid residues in the intracellular part of the Nod factor receptor NFR1 control signalling specificity and enable the distinction of immune and symbiotic response...
• T. rex debate settled: contested fossils are smaller rival species, not juveniles AI翻译
  作者：Witmer, Lawrence M.
  作者单位：University System of Ohio; Ohio University; University System of Ohio; Ohio University
• Therapeutic vaccines can challenge pancreatic cancer before it takes hold AI翻译
  作者：King, Anthony