作者：Ku, Zhiqiang; Xie, Xuping; Hinton, Paul R.; Liu, Xinli; Ye, Xiaohua; Muruato, Antonio E.; Ng, Dean C.; Biswas, Sujit; Zou, Jing; Liu, Yang; Pandya, Deepal; Menachery, Vineet D.; Rahman, Sachi; Cao, Yu-An; Deng, Hui; Xiong, Wei; Carlin, Kevin B.; Liu, Junquan; Su, Hang; Haanes, Elizabeth J.; Keyt, Bruce A.; Zhang, Ningyan; Carroll, Stephen F.; Shi, Pei-Yong; An, Zhiqiang
作者：Liu, Yulai; Weidle, Connor; Mihaljevic, Ljubica; Watson, Joseph L.; Li, Zhe; Yu, Le Tracy; Majumder, Sagardip; Borst, Andrew J.; Carr, Kenneth D.; Kibler, Ryan D.; Gamal El-Din, Tamer M.; Catterall, William A.; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; Howard Hughes Medical Institute; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Native ion channels play key roles in biological systems, and engineered versions are widely used as chemogenetic tools and in sensing devices1,2. Protein design has been harnessed to generate pore-containing transmembrane proteins, but the design of selectivity filters with precise arrangements of amino acid side chains specific for a target ion, a crucial feature of native ion channels3, has been constrained by the lack of methods for placing the metal-coordinating residues with atomic-level...
作者：Avni, Raz; Kamal, Nadia; Bitz, Lidija; Jellen, Eric N.; Bekele, Wubishet A.; Angessa, Tefera T.; Auvinen, Petri; Bitz, Oliver; Boyle, Brian; Canales, Francisco J.; Carlson, Craig H.; Chapman, Brett; Chawla, Harmeet Singh; Chen, Yutang; Copetti, Dario; Correia De Lemos, Samara; Dang, Viet; Eichten, Steven R.; Klos, Kathy Esvelt; Fenn, Amit M.; Fiebig, Anne; Fu, Yong-Bi; Gundlach, Heidrun; Gupta, Rajeev; Haberer, Georg; He, Tianhua; Herrmann, Matthias H.; Himmelbach, Axel; Howarth, Catherine J.; Hu, Haifei; Isidro Y Sanchez, Julio; Itaya, Asuka; Jannink, Jean-Luc; Jia, Yong; Kaur, Rajvinder; Knauft, Manuela; Langdon, Tim; Lux, Thomas; Marmon, Sofia; Marosi, Vanda; Mayer, Klaus F. X.; Michel, Steve; Nandety, Raja Sekhar; Nilsen, Kirby T.; Paczos-Grzeda, Edyta; Pasha, Asher; Prats, Elena; Provart, Nicholas J.; Ravagnani, Adriana; Reid, Robert W.; Schlueter, Jessica A.; Schulman, Alan H.; Sen, Taner Z.; Singh, Jaswinder; Singh, Mehtab; Sirijovski, Nick; Stein, Nils; Studer, Bruno; Viitala, Sirja; Vronces, Shauna; Walkowiak, Sean; Wang, Penghao; Waters, Amanda J.; Wight, Charlene P.; Yan, Weikai; Yao, Eric; Zhang, Xiao-Qi; Zhou, Gaofeng; Zhou, Zhou; Tinker, Nicholas A.; Fiedler, Jason D.; Li, Chengdao; Maughan, Peter J.; Spannagl, Manuel; Mascher, Martin
作者单位：Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Natural Resources Institute Finland (Luke); Brigham Young University; Agriculture & Agri Food Canada; Murdoch University; Western Crop Genetics Alliance; Murdoch University; University of Helsinki; Laval University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Agricultura Sostenible (IAS); United States Department of Agriculture (USDA); University of Manitoba; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Arizona; General Mills, Inc.; United States Department of Agriculture (USDA); Agriculture & Agri Food Canada; Aberystwyth University; Universidad Politecnica de Madrid; Instituto Nacional Investigacion Tecnologia Agraria Alimentaria (INIA); United States Department of Agriculture (USDA); Cornell University; Lund University; United States Department of Agriculture (USDA); Agriculture & Agri Food Canada; University of Life Sciences in Lublin; University of Toronto; University of Toronto; University of North Carolina; University of North Carolina Charlotte; University of California System; University of California Berkeley; Martin Luther University Halle Wittenberg; Murdoch University; PepsiCo; Murdoch University; Department of Primary Industries & Regional Development NSW; Shandong Agricultural University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv)
