-
作者：Echigoya, Syun; Ohmura, Takuya; Sato, Katsuhiko; Nakagaki, Toshiyuki; Nishigami, Yukinori
作者单位：Hokkaido University; Hokkaido University; Hokkaido University; University of Toyama
摘要：Organisms often inhabit environments comprising complex structures across various scales. Animals rely on visual information from surrounding geometrical structures for navigation. Even at the microscale, various microsediments form complex structures in microbial habitats. The movement of microorganisms is passively affected by collisions and hydrodynamic interactions with surrounding structures. However, the influence of microenvironmental geometry on behavioral changes of unicellular organi...
-
作者：Prigent, Iris; Mullon, Charles
作者单位：University of Lausanne
摘要：Many traits influence fitness indirectly by modifying shared environments that are transmitted across generations, a process known as ecological inheritance. Here, we investigate how variation in traits to improve common resources emerges when locally modified environments show ecological inheritance. Using eco-evolutionary modeling, we reveal that ecological inheritance, when combined with limited dispersal, can facilitate the coexistence of two types with opposite ecological legacies: enviro...
-
作者：Camargo- dos-Santos, Bruno; Taborsky, Barbara
作者单位：University of Bern; Wageningen University & Research
摘要：The social environment experienced during development plays a crucial role in shaping social competence-the ability to respond appropriately to social challenges. Sibling number and the social interactions between them are key components of the early lives in many animals. While these components are well known to influence social development in humans, their role in nonhuman animals remains unclear. Here, we show that both the number of siblings and opportunities for social interaction are ess...
-
作者：Hrncir, Vaclav; Sheehan, Oliver; Claessens, Scott; Gray, Russell D.
作者单位：Max Planck Society; University of Auckland; University of Kent
摘要：Humans have been using psychoactive substances for millennia, despite their potential negative health and social consequences. According to some scholars, our craving for mind-altering drugs is an evolutionary mistake-a hijacking of our reward system. In contrast, the drunk hypothesis argues that intoxication has been adaptive and essential for the rise of large-scale societies because it promotes social bonding, increases cooperation, alleviates stress, and enhances human creativity.Here, we ...
-
作者：Huang, Zimo; Bisby, James A.; Burgess, Neil; Bush, Daniel
作者单位：University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London
摘要：Human behavior often relies on executing a specific sequence of actions to achieve a desired outcome. However, the neural mechanisms underlying the dynamic construction and maintenance of such sequences during goal- directed behavior are not yet clear. Empirical and theoretical studies of working memory function suggest that sequential information may be encoded in neural circuits by bursts of gamma activity occurring at consecutive theta phases. Here, we asked whether a similar coding scheme ...
-
作者：Zhang, Qi; Qin, Lanju; Wang, Tongtong; Li, Zhangqiang; Zhang, Yilin; Chen, Sheng; Ge, Qijun; Wen, Jialing; Yan, Nieng; Wang, Jiawei; Hu, Mingxu
作者单位：Shenzhen Medical Academy of Research & Translation (SMART); Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University
摘要：Glycans are not only one of the four fundamental macromolecular classes that constitute life, but also the most abundant among these four across the Earth. However, compared with proteins and nucleic acids, our understanding of the structures and functional mechanisms of glycans remains limited. Moreover, it is generally challenging to obtain high-resolution three-dimensional structures of glycans. Recent studies have demonstrated the potential of the CryoSeek strategy in enabling high-through...
-
作者：Ganguly, Abira; Zmuda, Hannah; Abello, Javier; Illy, Danielle; Walter, Christopher; Tsatskis, Yonit; Thanintorn, Nattapon; Zhang, Ying; Hakim, Bilal Ahmad; Hodzic, Didier; Stratman, Amber N.; Jurisicova, Andrea; Pathak, Amit; Mcneill, Helen
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; University of Toronto; University of Toronto
摘要：Nuclear Envelope Membrane Protein 1 (NEMP1) is crucial for metazoan fertility; loss of Nemp1 causes death of primordial oocytes that reside in the mechanically challenging ovarian cortex. Here, we show that softening the ovary rescues oocyte loss and restores substrates leads to death, while cells remain viable on soft substrates. We further show Mechanistically, Nemp1-depleted cells on stiff substrates or subjected to stretching exhibit reduced nuclear YAP localization, and expressing nuclear...
