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作者：Kaiser, Jocelyn; Mervis, Jeffrey
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作者：Hanina, Sophie A.; Park, Tyler; Lopez, Michael; Rajasekhar, Vinagolu K.; Mansilla-Soto, Jorge; Haubner, Sascha; Zhao, Huiyong; Kogel, Friederike; Nataraj, Sarah; Banerjee, Priyam; Koche, Richard; Hamard, Pierre-Jacques; Tarcan, Zeynep C.; Chi, Dennis S.; Zamarin, Dmitriy; Healey, John H.; de Stanchina, Elisa; Motzer, Robert J.; Kotecha, Ritesh R.; Hakimi, A. Ari; Leslie, Christina S.; Sadelain, Michel
作者单位：Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Rockefeller University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Icahn School of Medicine at Mount Sinai; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; H Lee Moffitt Cancer Center & Research Institute; H Lee Moffitt Cancer Center & Research Institute; H Lee Moffitt Cancer Center & Research Institute; H Lee Moffitt Cancer Center & Research Institute
摘要：Solid tumor antigen heterogeneity is a major challenge for cancer immunotherapies, including chimeric antigen receptor (CAR) T cells. Unlike CD19 for B cell malignancies, no target with pan-cellular expression in solid tumors and absence in normal vital cells has been identified. CD70 is a promising candidate, physiologically confined to immune cell subsets and aberrantly expressed in many cancers. We show that heterogeneous CD70 expression in tumors is epigenetically regulated, ranging from h...
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作者：Khan, Muhammad Shehryar
作者单位：University of Calgary
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作者：Thaler, Perri
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作者：Beale, Andrew D.; Christmas, Matthew J.; Rzechorzek, Nina M.; Mihut, Andrei; Zeng, Aiwei; Ellis, Christopher; James, Nathan R.; Smyllie, Nicola J.; Pilorz, Violetta; Richardson, Rose; Bertelsen, Mads F.; Fazal, Shaline V.; Voysey, Zanna; Moreau, Kevin; Pelletier, Jerry; Crosby, Priya; Peak-Chew, Sew Y.; Edgar, Rachel S.; Lancaster, Madeline A.; Hut, Roelof A.; O'Neill, John S.
作者单位：MRC Laboratory Molecular Biology; Uppsala University; University of Cambridge; Imperial College London; Francis Crick Institute; University of Lubeck; University of Manchester; University of Cambridge; AstraZeneca; McGill University; University of California System; University of California Santa Cruz; University of Edinburgh; University of Groningen
摘要：Early mammals were nocturnal while dinosaurs dominated the daytime. Mammalian transition to daytime activity accelerated after the Cretaceous-Paleogene extinction, but the underlying mechanisms remain unclear. We identified a conserved cell-intrinsic, thermodynamic mechanism that likely facilitated this shift. In cells from diurnal mammals, protein synthesis, phosphorylation, and circadian timing were less sensitive to temperature changes than were cells from nocturnal mammals. Comparative gen...
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作者：Greenhough, Luke A.; Galanti, Lorenzo; Liang, Chih-Chao; Boulton, Simon J.; West, Stephen C.
作者单位：Francis Crick Institute; Francis Crick Institute
摘要：Homologous recombination repairs DNA double-strand breaks and protects stalled replication forks, but how the five RAD51 paralogs contribute to these processes remains unclear. Mutations in the RAD51 paralogs are linked to heritable breast and ovarian cancers and the cancer-prone disease Fanconi anemia. In this work, we show that the RAD51 paralogs assemble into two distinct heterotetrameric complexes, RAD51B-RAD51C-RAD51D-XRCC2 (RAD51B complex) and XRCC3-RAD51C-RAD51D-XRCC2 (XRCC3 complex). T...
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作者：Li, Feng
作者单位：University of Sydney
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作者：Stone, Richard
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作者：Cornwall, Warren
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作者：Dong, Ziyang; Zhao, Changgui
作者单位：Beijing Normal University
