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作者：Collado-Sole, Alejandro; Borjini, Nozha; Zhai, Jing; Ruiz-Pino, Francisco; Soria-Alcaide, Gonzalo; Folgueira, Cintia; Garcia-Vilela, Celia; Romero-de la Rosa, Beatriz; Lopez, Victor; Zouaghi, Yassine; Jacobs, An; Mora-Romero, Bella; Barranco, Alexandra; Yoldi, Guillermo; Rizzoti, Karine; Sabio, Guadalupe; Perez-Chacon, Gema; Santamaria, Patricia G.; Esteban, Jose Antonio; Journiac, Nathalie; Prevot, Vincent; Pascual, Alberto; Fernandez-Chacon, Rafael; Tena-Sempere, Manuel; Pitteloud, Nelly; Gonzalez-Suarez, Eva
作者单位：Centro Nacional de Investigaciones Oncologicas (CNIO); Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; Virgen del Rocio University Hospital; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); University of Sevilla; CIBERNED; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; Hospital Universitario Reina Sofia - Cordoba; Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en Red; Instituto de Salud Carlos III; CIBEROBN; Centro Nacional de Investigaciones Cardiovasculares (CNIC); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Biologia Molecular Severo Ochoa (CBM); Stanford University; Stanford Medicine; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Sevilla; University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Francis Crick Institute; University of London; Queen Mary University London; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Lille; CHU Lille; Universite de Lille
摘要：The hypothalamic-pituitary-gonadal axis (HPG) controls pubertal development, sexual maturation, and fertility. We identified a role of hypothalamic microglia in controlling the HPG axis through receptor activator of nuclear factor kappa B (Rank) signaling. Whole-body and microglia Rank (mouse) depletion led to hypogonadotropic hypogonadism (HH) resulting from an alteration in gonadotropin-releasing hormone (GnRH) neuron function. In addition, we identified rare gene variants of RANK (human) in...
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作者：Grimm, David
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作者：Liu, Shelley H.
作者单位：Icahn School of Medicine at Mount Sinai
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作者：Beaudrot, Lydia
作者单位：Michigan State University; Michigan State University
摘要：Human mobility data expand ecological analyses of people's impact on wild animals
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作者：Tindall, Joseph; Mello, Antonio Francesco; Fishman, Matthew; Stoudenmire, E. Miles; Sels, Dries
作者单位：Simons Foundation; Flatiron Institute; International School for Advanced Studies (SISSA); Boston University
摘要：Large-scale quantum annealing dynamics of Ising spin glasses were recently implemented on D-Wave's Advantage2 system on a range of lattices. After extensive comparison with existing numerical methods, these experiments were claimed to be beyond the reach of classical computation. Here, we simulated these spin-glass models with lattice-specific tensor networks, using belief propagation (BP) to keep up with the entanglement generated during the time evolution and then extracting expectation valu...
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作者：da Silva, Nicolas Antonio; Nebel, Almut; Kolbe, Daniel; Myburgh, Daniel Anton; Klimscha, Florian; Gorner, Irina; Fuchs, Katharina; Meyer, Christian; Schierhold, Kerstin; Rind, Michael; Hoffmann, Robert; Franke, Andre; Meadows, John; Rinne, Christoph; Muller, Johannes; Krause-Kyora, Ben
作者单位：University of Kiel; University of Kiel; University of Kiel
摘要：Megalithic monuments in Late Neolithic Europe are often viewed as symbols of shared ancestry. In this study, we analyzed genome-wide data of 203 individuals buried in six megalithic grave complexes associated with the Western Funnel Beaker and Wartberg groups. Despite being considered archaeologically distinct, our results show that the studied individuals from both groups form a genetically homogeneous population. Moreover, we identified first- and second-degree relationships spanning up to 2...
