6768期

最新文章

• The paradox of AI accelerationism and the promise of public interest AI AI翻译
  作者：Okolo, Chinasa T.
• Pharma's hot zone A new generation of radiotherapies promises a more targeted attack on cancer AI翻译
  作者：Service, Robert F.
• Intercellular communication in the brain through a dendritic nanotubular network AI翻译
  作者：Chang, Minhyeok; Krussel, Sarah; Parajuli, Laxmi Kumar; Kim, Juhyun; Lee, Daniel; Merodio, Alec; Kwon, Jaeyoung; Okabe, Shigeo; Kwon, Hyung-Bae
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; University of Tokyo; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Ruprecht Karls University Heidelberg; University of Freiburg; Korea Brain Research Institute (KBRI)
  摘要：Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite-dendrite nanotubes (DNTs) in mammalian cortex. Super-resolution microscopy in dissociated neurons revealed DNTs' actin-rich composition and dynamics, enabling long-range calcium ion (Ca2+) propagation. Imaging and machine learning-based analysis validated in situ DNTs as anatomically distinct from syn...
• Climate-linked escalation of societally disastrous wildfires AI翻译
  作者：Cunningham, Calum X.; Abatzoglou, John T.; Kolden, Crystal A.; Williamson, Grant J.; Steuer, Markus; Bowman, David M. J. S.
  作者单位：University of Tasmania; University of California System; University of California Merced; Munich RE Group
  摘要：Climate change and land mismanagement are creating increasingly fire-prone built and natural environments. However, despite worsening fire seasons, evidence is lacking globally for trends in socially and economically disastrous wildfires, partly due to sparse systematic records. Using a 44-year dataset (1980 to 2023) we analyze the distribution, trends, and climatic conditions connected with the most lethal and costly wildfires. Disastrous wildfires occurred globally over this period but were ...
• Dutch government agrees to return Java Man, thousands of other fossils to Indonesia AI翻译
  作者：Enserink, Martin
• Strengthening nucleic acid biosecurity screening against generative protein design tools AI翻译
  作者：Wittmann, Bruce J.; Alexanian, Tessa; Bartling, Craig; Beal, Jacob; Clore, Adam; Diggans, James; Flyangolts, Kevin; Gemler, Bryan T.; Mitchell, Tom; Murphy, Steven T.; Wheeler, Nicole E.; Horvitz, Eric
  作者单位：Microsoft; Battelle Memorial Institute; Integrated DNA Technologies IDT; University of Birmingham
  摘要：Advances in artificial intelligence (AI)-assisted protein engineering are enabling breakthroughs in the life sciences but also introduce new biosecurity challenges. Synthesis of nucleic acids is a choke point in AI-assisted protein engineering pipelines. Thus, an important focus for efforts to enhance biosecurity given AI-enabled capabilities is bolstering methods used by nucleic acid synthesis providers to screen orders. We evaluated the ability of open-source AI-powered protein design softwa...
• A comprehensive genetic catalog of human double-strand break repair AI翻译
  作者：de Alba, Ernesto Lopez; Salguero, Israel; Gimenez-Llorente, Daniel; Montes-Torres, Javier; Fernandez-Sanroman, Angel; Casajus-Pelegay, Ester; Terron-Bautista, Jose; Barroso-Gonzalez, Jonathan; Bernal, Juan A.; Macintyre, Geoff; Fernandez-Leiro, Rafael; Losada, Ana; Cortes-Ledesma, Felipe
  作者单位：Centro Nacional de Investigaciones Oncologicas (CNIO); Centro Nacional de Investigaciones Oncologicas (CNIO); Centro Nacional de Investigaciones Oncologicas (CNIO); Centro Nacional de Investigaciones Oncologicas (CNIO); Centro Nacional de Investigaciones Cardiovasculares (CNIC)
  摘要：The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) within a genome-wide knockout library, we present a comprehensive catalog that assesses the influence of nearly every human gene on DSB repair outcomes. This REPAIRome resource uncovers uncharacterized mechanisms, pathways, and factors involved in DSB repair, including opposing roles for XLF and PA...
• Persistent eastern equatorial Pacific Ocean upwelling since the warm Pliocene AI翻译
  作者：Rafter, Patrick A.; Farmer, Jesse R.; Martinez-Garcia, Alfredo; Ravelo, Ana Christina; Karnauskas, Kristopher B.; Batista, Fabian C.; Bernasconi, Stefano M.; Ren, Haojia; Auderset, Alexandra; Haug, Gerald H.; Sigman, Daniel M.
  作者单位：State University System of Florida; University of South Florida; University of California System; University of California Irvine; University of Massachusetts System; University of Massachusetts Boston; Princeton University; Max Planck Society; University of California System; University of California Santa Cruz; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Swiss Federal Institutes of Technology Domain; ETH Zurich; National Taiwan University; University of Southampton; NERC National Oceanography Centre
  摘要：Upwelling generates a nutrient-rich cold tongue in the eastern equatorial Pacific Ocean (EEP), with impacts on global climate, oceanic biological productivity, and the carbon cycle. The cold tongue was reduced during the Pliocene Epoch, a feature attributed to weaker upwelling and an associated deepening of the surface mixed layer in the EEP. Here, we report nitrogen-isotope evidence that modern-like upwelling occurred in the EEP during the Pliocene and has persisted over the past 5 million ye...
• Getting to the root of the pattern: Root barriers and metabolite leakage shape microbial colonization of plants AI翻译
  作者：Kozaeva, Ekaterina; Brophy, Jennifer A. N.
  作者单位：University of Copenhagen; Stanford University
• Integrated low-temperature PVC and polyolefin upgrading AI翻译
  作者：Zhang, Wei; Yang, Boda; Jackson, Benjamin A.; Zhao, Junbo; Shi, Honghong; Camaioni, Donald M.; Kim, Sungmin; Wang, Huamin; Szanyi, Janos; Lee, Mal-Soon; Chen, Jingguang G.; Lercher, Johannes A.
  作者单位：East China Normal University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Technical University of Munich; Technical University of Munich; Columbia University
  摘要：Polyolefins and their chlorinated derivatives such as polyvinyl chloride (PVC) are among the most prevalent plastics in global production and waste streams. Traditional waste-to-energy methods such as incineration and pyrolysis, as well as most chemical upcycling methods for PVC utilization, require thorough, high-temperature dechlorination to prevent the release of toxic chlorinated compounds. We present here a strategy for upgrading discarded PVC into chlorine-free fuel range hydrocarbons an...