6769期

最新文章

• Top-down cortical input during NREM sleep consolidates perceptual memory (Vol 352, pg 1315, 2016) AI翻译
  作者：Miyamoto, D.
• Long-lived gamma ray burst puzzles astronomers AI翻译
  作者：Clery, Daniel
• EU's global investments put biodiversity at risk AI翻译
  作者：Grilo, Clara; Beja, Pedro; Bernardino, Joana; Ferrand, Nuno; Laurance, William F.; Clevenger, Anthony P.
  作者单位：Universidade do Porto; Universidade de Lisboa; James Cook University; James Cook University; Montana State University System; Montana State University Bozeman
• MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists AI翻译
  作者：Hsu, Jung-Mao; Liu, Chunxiao; Xia, Weiya; Chen, Chung-Yu; Cheng, Wei-Chung; Hou, Junwei; Hung, Mien-Chie
  作者单位：China Medical University Taiwan; China Medical University Taiwan; Sun Yat Sen University; University of Texas System; UTMD Anderson Cancer Center; China Medical University Taiwan; China Medical University Taiwan; Central South University; Central South University; Asia University Taiwan
  摘要：Cytosolic nucleic acid-sensing pathways are potential targets for cancer immunotherapy. Although stimulator of interferon genes (STING) agonists have shown substantial antitumor effects in animal models, their clinical efficacy in human tumors remains unclear. Deletion of methylthioadenosine phosphorylase (MTAP) is a common genomic alteration in human tumors but is rare in preclinical syngeneic mouse models. We found that homozygous MTAP deletion in human tumors creates a tumor microenvironmen...
• Greater noctule bats prey on and consume passerines in flight AI翻译
  作者：Stidsholt, L.; Tena, E.; Foskolos, I.; Nogueras, J.; de la Hera, I.; Sanchez-Navarro, S.; Garcia-Mudarra, J. L.; Ibanez, C.
  作者单位：Aarhus University; Leibniz Institut fur Zoo und Wildtierforschung; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Aarhus University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Universidad de Extremadura; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Experimental de Zonas Aridas (EEZA)
  摘要：Despite billions of passerines seasonally migrating during the night at high altitudes, only three bat species have been found to consistently tap into this rich prey resource. However, it remains unknown where and how these bats locate, catch, and ingest relatively large passerine prey. Here, we used high-resolution biologging tags to reveal that greater noctule bats (Nyctalus lasiopterus) ascend to high altitudes, engage in long echo-guided chases, and consume migrating passerines in flight....
• A tripartite alliance for dietary fat absorption AI翻译
  作者：Burkhardt, Ralph; Ecker, Josef
  作者单位：University of Regensburg
• Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations AI翻译
  作者：Huang, Huihui; Wang, Yi; Zsengeller, Zsuzsanna K.; Gorham, Joshua M.; Vemireddy, Vamsidhara; Clark, Amanda J.; Pan, Hui; Dreyfuss, Jonathan M.; Jotwani, Vasantha; Shlipak, Michael G.; Sarnak, Mark J.; Parikh, Chirag R.; Thiessen-Philbrook, Heather; Katz, Ronit; Waikar, Sushrut S.; Lake, Nicole J.; Lek, Monkol; Shi, Wen; Puiu, Daniela; Hong, Yun Soo; Seidman, Jonathan G.; Arking, Dan E.; Parikh, Samir M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; University of California System; University of California San Francisco; Tufts Medical Center; Johns Hopkins University; Johns Hopkins Medicine; University of Washington; University of Washington Seattle; Boston Medical Center; Boston University; Yale University; Johns Hopkins University; Johns Hopkins Medicine
  摘要：Somatically acquired mitochondrial DNA (mtDNA) mutations accumulate with age, but the mechanisms and consequences of this accumulation are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA mutations that impair resilience to future injuries. mtDNA mutations suppressed energy-intensive nucleotide metabolism. Repletion of adenosine, but not other nucleotides, restored adenosine triphosphate generation, which required a nuclear-encoded purine biosynthetic ...
• Free global access to climate and weather data must continue AI翻译
  作者：Taalas, Petteri
  作者单位：Finnish Meteorological Institute
• The lithium dilemma AI翻译
  作者：Ali, Saleem H.
  作者单位：University of Delaware