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作者:Hessler, Angela; Jin, Sumin
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作者:Orfila, Maria De Los Angeles
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作者:Seong, Yeonjae; Kim, Hyunmin; Byun, Kyumi; Park, Yeon-Woo; Roh, Soung-Hun
作者单位:Seoul National University (SNU); Seoul National University (SNU); European Molecular Biology Laboratory (EMBL)
摘要:Microtubule assembly requires a set of chaperones known as tubulin-binding cofactors (TBCs). We used cryo-electron microscopy to visualize how human TBCD, TBCE, TBCC, and guanosine triphosphatase (GTPase) Arl2 mediate alpha beta-tubulin assembly and disassembly. We captured multiple conformational states, revealing how TBCs orchestrate tubulin heterodimer biogenesis. TBCD stabilizes monomeric beta-tubulin and scaffolds the other cofactors. Guanosine triphosphate (GTP) binding to Arl2 induces c...
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作者:Gao, Chang; Song, Wenlong; Wang, Huiqiu; Chen, Xiao; Cui, Chaojie; Hao, Wangshu; Yan, Ning; Yang, Yuan; Yang, Shenglong; Lv, Hao; Ma, Mingyu; Lian, Xinli; Zhang, Ruixia; Qian, Weizhong
作者单位:Tsinghua University
摘要:In synthesizing olefins from syngas, low hydrogen atom economy (HAE), the fraction of reactant hydrogen in the hydrocarbon product, arises from hydrogen loss in water by-product. We report a sodium-modified FeCx@Fe3O4 core-shell catalyst coupling water-gas shift (WGS) with syngas-to-olefins (STO) to convert water into hydrogen in situ. HAE reaches about 66 to 83%, exceeding that of methanol-to-olefins (MTO, 50% upper limit). The approximately 95% carbon monoxide conversion and >75% olefin sele...
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作者:Saeys, Mark
作者单位:Ghent University
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作者:Xu, Liuwei; Meng, Lingsen; Zhang, Yunjun; Yang, Yanchen; Wang, Yidi; Hu, Changyang; Weng, Huihui; Xu, Wenbin; Su, Elizabeth; Ji, Chen
作者单位:University of California System; University of California Los Angeles; Chinese Academy of Sciences; Aerospace Information Research Institute, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Aerospace Information Research Institute, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanjing University; Central South University; University of California System; University of California Santa Barbara
摘要:Joint seismic and geodetic analyses revealed that the 2025 moment magnitude (M-w) 7.8 Mandalay, Myanmar, earthquake ruptured similar to 510 km of the Sagaing fault, with a sustained supershear rupture extending similar to 450 km on the southern branch. Far-field Mach waves and near-field ground motion confirmed the supershear nature. This exceptionally long supershear rupture caused building collapse and soil liquefaction, as observed in satellite imagery, offering insights into the damage pot...
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作者:Bradley, Kyle E.; Hubbard, Judith A.
作者单位:Cornell University
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作者:Sorenson, Michael D.; Spottiswoode, Claire N.
作者单位:Boston University; University of Cape Town; University of Cambridge
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作者:Randi, Ettore; Jansman, Hugh; Kusak, Josip; Pacifici, Michela; Piovesan, Gianluca; Saarma, Urmas; Schmidt, Krzysztof; Werhahn, Geraldine
作者单位:Aalborg University; Wageningen University & Research; University of Zagreb; Koc University; Utah System of Higher Education; University of Utah; Sapienza University Rome; Tuscia University; University of Tartu; Tartu University Institute of Ecology & Earth Sciences; Polish Academy of Sciences; Mammal Research Institute of the Polish Academy of Sciences; University of Oxford
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作者:Tan, Peng; Jaiswal, Alok; Murphy, Shane P.; Brown, Eric M.; Wheeler, Hailey; Su, Chien-Wen; Finan, Emily P.; Jasso, Guadalupe J.; Shi, Hai Ning; Graham, Daniel B.; Delorey, Toni M.; Deguine, Jacques; Xavier, Ramnik J.
作者单位:Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Hainan Medical University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要:Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly understood. In this study, we regionally profiled enteric neurons across gnotobiotic, allergic, and parasite-infected mice. Timing and complexity of microbial perturbations and type 2 inflammation result in motor neuron state shifts and alter multiple functionally distinct sensory neurons, including...