6777期

最新文章

• The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin AI翻译
  作者：Carlson, Erik S.; Haslecker, Raphael; Lecchi, Chiara; Aguilar Ramos, Miguel A.; Vennelakanti, Vyshnavi; Honaker, Linda; Stornetta, Alessia; Millan, Estela S.; Johnson, Bruce A.; Kulik, Heather J.; Balbo, Silvia; Villalta, Peter W.; D'souza, Victoria M.; Balskus, Emily P.
  作者单位：Harvard University; Harvard University; University of Minnesota System; University of Minnesota Twin Cities; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); City University of New York (CUNY) System; University of Minnesota System; University of Minnesota Twin Cities; Harvard University; Howard Hughes Medical Institute; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Accumulating evidence has connected the chemically unstable, DNA-damaging gut bacterial natural product colibactin to colorectal cancer, including the identification of mutational signatures that are thought to arise from colibactin-DNA interstrand cross-links (ICLs). However, we currently lack direct information regarding the structure of this lesion. In this work, we combined mass spectrometry and nuclear magnetic resonance spectroscopy to elucidate the specificity and structure of the colib...
• Constraints on lepton number violation with the 2 tonne year CUORE dataset AI翻译
  作者：Bucci, Carlo
  摘要：Matter-antimatter asymmetry underlines the incompleteness of the current understanding of particle physics. Neutrinoless double-beta decay (0 nu beta beta) may help explain this asymmetry while unveiling the Majorana nature of the neutrino. The CUORE (Cryogenic Underground Observatory for Rare Events) experiment searches for 0 nu beta beta of Te-130 using a tonne-scale cryogenic calorimeter operated at milli-kelvin temperatures. We report no evidence of 0 nu beta beta and place a lower limit o...
• DOE boost for AI, fusion could squeeze basic research AI翻译
  作者：Cho, Adrian
• Centering disabled perspectives in technology Medical testing and devices must be reimagined to combat ableism, argues a disability scholar AI翻译
  作者：Flowers, Johnathan
  作者单位：California State University System; California State University Northridge
• Dawn of quantum simulators AI翻译
  作者：Roushan, Pedram; Martin, Leigh
  作者单位：Alphabet Inc.; Google Incorporated
  摘要：Large-scale quantum processors are beginning to uncover new physical phenomena
• Cell wall patterning regulates plant stem cell dynamics AI翻译
  作者：Zhu, Xianmiao; Chen, Xing; Liu, Yangxuan; Zhu, Yimin; Gao, Geshuang; Lan, Miao; Fu, Yihao; Gu, Yimin; Han, Han; Cai, Wenjuan; Wightman, Raymond; Gao, Mingjun; Ding, Yiliang; Yang, Weibing
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanjing Forestry University; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; University of Cambridge; Fudan University; Fudan University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Centre; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
  摘要：The plant cell wall regulates development through spatiotemporal modulation of its chemical and mechanical properties. Pectin methylesterification is recognized as a rheological switch controlling wall stiffness. Here, we reveal a bimodal methylesterification pattern in the shoot meristem: Mature walls exhibit high methylesterification, whereas demethylesterified pectins are deposited at new cross walls. This spatial heterogeneity is established through nuclear sequestration of PECTIN METHYLES...
• Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance AI翻译
  作者：Cazares, Adrian; Figueroa, Wendy; Cazares, Daniel; Lima, Leandro; Turnbull, Jake D.; McGregor, Hannah; Dicks, Jo; Alexander, Sarah; Iqbal, Zamin; Thomson, Nicholas R.
  作者单位：Wellcome Trust Sanger Institute; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; University of Cambridge; University of Oxford; UK Health Security Agency (UKHSA); University of Bath; University of London; London School of Hygiene & Tropical Medicine
  摘要：Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialization of antibiotics influenced their evolution is limited by a paucity of data predating the antibiotic era (PAE). By investigating plasmids from clinically relevant bacteria sampled and isolated between 1917 and 1954 and comparing them with modern plasmids, we have captured more than 100 years of evolution. We show that although virtually all PAE plasmids were devoid of resistance...
• Toward science-based conviction criteria to deter wildlife crime AI翻译
  作者：Hu, Ruocheng; Liu, Shuangqi; Xiao, Lingyun; Zhu, Ziyun; Dou, Yuehan; Zhang, Shen; Ren, Xiaotong; Hua, Fangyuan; Lu, Zhi
  作者单位：Peking University; Peking University; Peking University; Xi'an Jiaotong-Liverpool University; Duke Kunshan University; Princeton University
  摘要：Amid the ongoing global biodiversity crisis (1), a key policy mechanism for species conservation is to establish and enforce scientifically grounded rules to define whether harmful activities-such as poaching, trade, and habitat destruction-constitute criminal behavior and should be convicted (2). China in recent years has made multiple amendments to its conviction criteria for crime on terrestrial vertebrates, including changing the basis of the criteria from the numbers of animal individuals...
• Improved solvent systems for commercially viable perovskite photovoltaic modules AI翻译
  作者：Wang, Yinke; Liu, Ye; Luo, Xin; Xiao, Ke; Marrugat-Arnal, Victor; Xu, Dongdong; Lou, Jing; Zuo, Weiwei; Tavakoli, Navid; Li, Tiantian; Yang, Yuanbo; Duan, Chenyang; Ou, Wennan; Liu, Yuxuan; Hong, Jiajia; Sun, Hongfei; Duan, Gongtao; Li, Manya; Gao, Han; Chu, Zijing; Jiang, Long; Saliba, Michael; Saidaminov, Makhsud I.; Chang, Chao; Tan, Hairen
  作者单位：Nanjing University; University of Victoria; University of Stuttgart; China National Petroleum Corporation; Helmholtz Association; Julich Research Centre; University of Victoria
  摘要：Commercializing perovskite photovoltaics requires overcoming three critical barriers: the use of toxic solvents in manufacturing, variations in perovskite film quality across large areas, and limited operational reliability. Here, we address these challenges by developing a green solvent-based (gamma-valerolactone/2-methyl tetrahydrofuran/dimethylsulfoxide) ink and a solvent-confinement edge-protection strategy, demonstrating large-scale manufacturing of defect-minimized perovskite films under...
• Hexatic phase in covalent two-dimensional silver iodide AI翻译
  作者：Bui, Thuy An; Lamprecht, David; Madsen, Jacob; Kurpas, Marcin; Kotrusz, Peter; Markevich, Alexander; Mangler, Clemens; Kotakoski, Jani; Filipovic, Lado; Meyer, Jannik C.; Pennycook, Timothy J.; Skakalova, Viera; Mustonen, Kimmo
  作者单位：University of Vienna; Technische Universitat Wien; University of Silesia in Katowice; Slovak Academy of Sciences; Institute of Electrical Engineering, SAS; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Eberhard Karls University of Tubingen; University of Antwerp; University of West Bohemia Pilsen
  摘要：According to the Kosterlitz-Thouless-Halperin-Nelson-Young (KTHNY) theory, the transition from a solid to liquid in two dimensions proceeds through an orientationally ordered liquid-like hexatic phase. However, alternative mixed melting scenarios, in which melting proceeds through the hexatic phase with both continuous and discontinuous transitions, have also been observed in some two-dimensional systems. In this study, we imaged silver iodide embedded in multilayer graphene using time- and te...