6783期

最新文章

• As Greenland loses ice, global sea levels will rise-and its own will fall AI翻译
  作者：Howell, Evan
• Regulate worker heat exposure in global trade AI翻译
  作者：Liu, Chang; Teng, Jiafei; Fan, Hongmin
  作者单位：Harbin Institute of Technology; Liaoning Technical University; Liaoning University
• Purdue blocks admission of many Chinese grad students AI翻译
  作者：Mervis, Jeffrey
• A 5500-year-old Treponema pallidum genome from Sabana de Bogotá, Colombia AI翻译
  作者：Bozzi, Davide; Broomandkhoshbacht, Nasreen Z.; Delgado, Miguel; Buikstra, Jane E.; Amorim, Carlos Eduardo G.; Kassadjikova, Kalina; Estrada, Melissa Pratt; Greub, Gilbert; Rascovan, Nicolas; Smajs, David; Fehren-Schmitz, Lars; Malaspinas, Anna-Sapfo; Nelson, Elizabeth A.
  作者单位：University of Lausanne; Swiss Institute of Bioinformatics; University of California System; University of California Santa Cruz; National University of La Plata; Museo La Plata; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Fudan University; Fudan University; Arizona State University; Arizona State University-Tempe; California State University System; California State University Los Angeles; University of Lausanne; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris; Masaryk University; University of California System; University of California Santa Cruz; Southern Methodist University
  摘要：Treponematosis, a bacterial infection caused by Treponema pallidum subspecies and T. carateum (yaws, bejel, syphilis, pinta), has afflicted humans for millennia. Despite paleopathological evidence and emerging genomic data, little is known about the evolutionary history of these pathogens. We report a 5500-year-old Treponema genome (TE1-3) from Middle Holocene hunter-gatherer contexts of the rock shelter Tequendama I in Colombia. Our analyses place TE1-3 as a sister lineage to all known T. pal...
• Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development AI翻译
  作者：Xiang, Yangquan; Qian, Yuli; Li, Zhengyi; Wang, Jiaxu; Tian, Ruonan; Meng, Weikang; Bu, Jiabao; Huang, Fei; Ai, Zhipeng; Wu, Danya; Chen, Xijia; Wu, You; Shen, Li; Chan, Yun-Shen; Gao, Yawei; Ma, Jun; Liu, Wanlu; Gao, Shaorong; Zhang, Dan; Liang, Hongqing
  作者单位：Zhejiang University; Zhejiang University; Agency for Science Technology & Research (A*STAR); A*STAR - Genome Institute of Singapore (GIS); Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Tongji University; Guangzhou Laboratory; Tongji University; Tongji University; Zhejiang University; Zhejiang University
  摘要：Zygotic genome activation (ZGA) failure leads to developmental arrest and poses a clinical challenge to women's fertility. We observed that human embryos arresting at the eight-cell ZGA stage exhibited specific down-regulation of endogenous retrovirus MLT2A1. Depleting MLT2A1 resulted in a failure in embryo development and a reduction in ZGA gene expression. Mechanistically, MLT2A1s synthesized chimeric transcripts with downstream coding and noncoding sequences, predominantly with heterologous...
• Talking back AI翻译
  作者：Malakoff, David
• Couple-close: Unified approach to semisaturated cyclic scaffolds AI翻译
  作者：Xie, Jiaxin; Zhao, William Y.; Wang, Johnny Z.; Lyon, William L.; Takanashi, Noriyuki; Long, Alice; Sodano, Taylor M.; Kelly, Christopher B.; Bryan, Marian C.; Macmillan, David W. C.
  作者单位：Princeton University
  摘要：Couple-close as a synthetic paradigm has the potential to change the way that synthetic organic chemists approach cyclic scaffold construction. One class of cyclic molecules that has been increasingly sought after is semisaturated cyclic scaffolds, whose specific blend of Csp2- and Csp3-hybridized components confers distinct properties to these species. However, existing methods to construct these scaffolds are limited, often relying on arene saturation or annulations that require lengthy de n...
• States pioneer a new frontier in US science funding AI翻译
  作者：Alexander, Jeffrey; Estabrooke, Ivy
  作者单位：Research Triangle Institute; Research Triangle Institute
• Damage assessment AI翻译
  作者：Mervis, Jeffrey
• Pan-family pollen signals control an interspecific stigma barrier across Brassicaceae species AI翻译
  作者：Cao, Yunyun; Cui, Xiaoshuang; Yang, Yinqing; Pan, Lianhui; Yang, Fei; Li, Shuyan; Wu, Dandan; Ding, Yuelan; Chen, Rui; Wang, Nan; Liu, Shangjia; Ji, Zhaojing; Zhao, Yuxuan; Chen, Yue; Sun, Rui; Xian, Shiyu; Yang, Lin; Hui, Jiyun; Li, Ru; Zhang, Tong; Dou, Shengwei; Song, Gengxing; Wei, Xiaochun; Yuan, Yuxiang; Zhang, Xiaowei; Chen, Mingming; Sun, Xihai; Wu, Hen-Ming; Cheung, Alice Y.; Duan, Qiaohong
  作者单位：Shandong Agricultural University; University of Massachusetts System; University of Massachusetts Amherst; Henan Academy of Agricultural Sciences
  摘要：Prezygotic interspecific incompatibility prevents hybridization between species, which limits interbreeding strategies for crop improvement using wild relatives. The Brassica rapa female self-incompatibility determinant, S-locus receptor kinase (SRK), recognizes interspecific pollen. Here, we report the discovery of a pan-Brassicaceae SRK-interacting interspecific pollen signal (SIPS). On B. rapa stigmas, SIPSs from Arabidopsis and other Brassicaceae species target BrSRK and recruit the female...