6804期

最新文章

• Violet seed propulsion inspires robot design Comparative analysis of seed biomechanics reveals principles that can guide soft robot technolog AI翻译
  作者：Patek, S. N.
  作者单位：Duke University
• A metastable solid solution transforms into complex nanostructures AI翻译
  作者：Sun, Wenhao; Misra, Amit
  作者单位：University of Michigan System; University of Michigan
• Inheriting trauma, rethinking science AI翻译
  作者：Dajani, Rana
  作者单位：Hashemite University
• Unlikely chemistry of life may have originated on the ocean floor AI翻译
  作者：Callier, Viviane
• Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting AI翻译
  作者：Fan, Hao; Zheng, Zhong; Oliphant, Kaitlyn; Li, Jiacheng; Mack, Ryan; Ju, Cheng-Wei; Trandai, Brandon; Tu, Jiayi; Zhang, Freya Q.; Zhang, Rukang; Xie, Zhicheng; Yin, Chunzhao; Cai, Chufan; Kennedy, Megan S.; McNeely, Tess; Cham, Candace; Shah, Hardik; Dong, Lei; Su, Rui; Martin, Camilia R.; Layden, Brian T.; Hamanaka, Robert B.; Mutlu, Gokhan M.; Chang, Eugene B.; Zhang, Jiwang; Chi, Hongbo; Claud, Erika C.; He, Chuan; Chen, Jing
  作者单位：University of Chicago; University of Chicago; University of Chicago; Loyola University Chicago; University of Chicago; University of Texas System; University of Texas Southwestern Medical Center; City of Hope; Beckman Research Institute of City of Hope; Cornell University; Weill Cornell Medicine; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; St Jude Children's Research Hospital
  摘要：How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the predominant naturally occurring trans-fatty acid in human breast milk, promoted neonatal T cell development in mice. Neonates fed by mothers on a TVA-enriched diet showed an expanded na & iuml;ve cluster of differentiation 4 (CD4+) T cell population and enhanced adaptive immunity against infection...
• Tracking the roots of zoonoses AI翻译
  作者：Key, Felix M.
  作者单位：Max Planck Society
• CD4+ T cells impair tumor growth through IL-3 and TNF-dependent vascular damage AI翻译
  作者：Lian, Qiaoshi; Nie, Jia; Singh, Jatinder; Chen, Qiang; Matta, Jennifer; Chan, Waipan; Balmaceno-Criss, Mariah; Vacchio, Melanie S.; Yu, Weiming; Clark, Alexander D.; Edmondson, Elijah; Kelly, Michael C.; Germain, Ronald N.; Bosselut, Remy
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
  摘要：Most cancer immunotherapy strategies are focused on direct tumor killing by immune cells, especially T lymphocytes. Clinical and conceptual limitations of these approaches create a need for additional strategies. We identified a tumor stroma-targeting mechanism in which tumor antigen-specific CD4+ T cells inhibit tumor growth through myeloid cell and tumor necrosis factor (TNF)-dependent vascular damage. Multiplex immunofluorescence and single-cell and tissue transcriptomics showed that CD4+ T...
• El Niño is here. It may be the strongest this century AI翻译
  作者：Richter, Hannah
• Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design AI翻译
  作者：Skelly, Ashwin N.; Gristick, Harry B.; Li, Hui; Gavor, Edem; Connell, Andrew J.; Kreider, Edward F.; Marchitto, Lorie; Hogarty, Michael P.; Newby, Maddy L.; Allen, Joel D.; Liu, Weimin; West, Anthony P.; Ayyanathan, Kasirajan; Campion, Mary S.; Winters, Kaitlyn; Gordon, Colette G.; Osbaldeston, Rebecca A.; Akeley, Macy J.; Lewis, Emily; Li, Yingying; Singh, Ajay; Cruickshank, Kendra; Park, Younghoon; Zhao, Chengyan; Li, Xuduo; Amereh, Khaled; Van Itallie, Elizabeth; Carey, John W.; Albertus, Amie; DeLaitsch, Andrew T.; Keeffe, Jennifer R.; Lituchy, Melinda G.; Walsh, Agnes A.; Morris, Daniel J.; Habib, Rumi; Bibollet-Ruche, Frederic; Mishra, Nitesh; Avillion, Gabriel; Koranda, Nicholas S.; Plante, Samantha J.; Martella, Christian L.; Lora, Jinery; Wang, Eric J. D.; Lewis, Mark G.; Martin, Malcolm A.; Nussenzweig, Michel C.; Seaman, Michael S.; Irvine, Darrell J.; Wiehe, Kevin J.; Haynes, Barton F.; Wagh, Kshitij; Korber, Bette; Andrabi, Raiees; Crispin, Max; Weissman, Drew; Bjorkman, Pamela J.; Hahn, Beatrice H.; Shaw, George M.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; California Institute of Technology; University of Pennsylvania; Pennsylvania Medicine; University of Southampton; Duke University; Duke University; Scripps Research Institute; BIOQUAL Inc.; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Howard Hughes Medical Institute; United States Department of Energy (DOE); Los Alamos National Laboratory
  摘要：A major obstacle confronting HIV-1 vaccine and cure research is the lack of an outbred animal model for rapid and consistent induction of broadly neutralizing antibodies (bNAbs). We designed an epitope-focused simian-human immunodeficiency virus (SHIV.5MUT) that elicited broad and potent V3-glycan-targeted antibodies within a year of infection in 14 of 22 macaques compared with 0 of 14 control animals. SHIV.5MUT elicited bNAbs by a two-step mechanism, inducing an initial wave of V1-directed an...
• Decoupling of global metabolic flux and proteome partitioning in bacteria AI翻译
  作者：Thiermann, Ryan; Yang, Jin; Zodage, Aniket; She, Fukang; Fung, Danny K.; Rytlewski, Taylor; Abdollah-Nia, Farshad; Xiao, Fangzhou; Sauls, John T.; Cox, Sarah; Ghulam-Jelani, Zulfar; Castillo, Victoria; Paulsen, Quinn A.; Stevenson, David M.; Amador-Noguez, Daniel; Williamson, James R.; Wang, Jue D.; Jun, Suckjoon
  作者单位：University of California System; University of California San Diego; University of Wisconsin System; University of Wisconsin Madison; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas Dallas; Scripps Research Institute; Westlake University
  摘要：Bacteria regulate homeostatic growth by adjusting proteome composition. In Escherichia coli, this coordination is mediated by guanosine tetraphosphate and pentaphosphate, collectively termed (p)ppGpp, which couple amino acid supply with ribsosome production. We identified a distinct architecture in Bacillus subtilis, in which guanosine triphosphate (GTP), not (p)ppGpp, controls proteome allocation. Translational inhibition resulted in GTP depletion and suppressed amino acid biosynthesis throug...