作者：KOSOROK, MR; FLEMING, TR
作者单位：University of Washington; University of Washington Seattle
摘要：In clinical trials with failure time outcomes, the cost of follow-up for the endpoint of primary interest is sometimes expensive. In many of these settings, one or more secondary or surrogate failure time outcomes are also available which either occur much earlier or are much less expensive to follow than the primary outcome. This paper presents a method for using these secondary outcomes to increase the power of detecting a treatment effect on the primary outcome only, without introducing bia...
