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作者：Li, Wenlong; Liu, Min-Qian; Tang, Boxin
作者单位：Nankai University; Simon Fraser University
摘要：An attractive type of space-filling design for computer experiments is the class of maximin distance designs. Algorithmic search is commonly used for finding such designs, but this approach becomes ineffective for large problems. Theoretical construction of maximin distance designs is challenging; some results have been obtained recently, often using highly specialized techniques. This article presents an easy-to-use method for constructing maximin distance designs. The method is versatile as ...
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作者：Frongillo, Rafael M.; Kash, Ian A.
作者单位：University of Colorado System; University of Colorado Boulder; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
摘要：A property, or statistical functional, is said to be elicitable if it minimizes the expected loss for some loss function. The study of which properties are elicitable sheds light on the capabilities and limitations of point estimation and empirical risk minimization. While recent work has sought to identify which properties are elicitable, here we investigate a more nuanced question: how many dimensions are required to indirectly elicit a given property? This number is called the elicitation c...
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作者：Gunsilius, F. F.
作者单位：University of Michigan System; University of Michigan
摘要：This note presents a proof of the conjecture in Pearl (1995) about testing the validity of an instrumental variable in hidden variable models. It implies that instrument validity cannot be tested in the case where the endogenous treatment is continuously distributed. This stands in contrast to the classical testability results for instrument validity when the treatment is discrete. However, imposing weak structural assumptions on the model, such as continuity between the observable variables, ...
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作者：Zhou, Huijuan; Zhang, Xianyang; Chen, Jun
作者单位：Renmin University of China; Texas A&M University System; Texas A&M University College Station; Mayo Clinic
摘要：The familywise error rate has been widely used in genome-wide association studies. With the increasing availability of functional genomics data, it is possible to increase detection power by leveraging these genomic functional annotations. Previous efforts to accommodate covariates in multiple testing focused on false discovery rate control, while covariate-adaptive procedures controlling the familywise error rate remain underdeveloped. Here, we propose a novel covariate-adaptive procedure to ...
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作者：Bubenik, Peter
作者单位：State University System of Florida; University of Florida
摘要：Garside et al. (2021) use event history methods to analyse topological data. We provide additional background on persistent homology to contrast the hazard estimators used in Garside et al. (2021) with standard approaches in topological data analysis. In particular, Garside et al.'s approach is a local method, which has advantages and disadvantages, whereas homology is global. We also provide more details on persistence landscapes and show how a more complete use of this statistic improves its...
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作者：Zeng, Donglin; Lin, D. Y.
作者单位：University of North Carolina; University of North Carolina Chapel Hill
摘要：Panel count data, in which the observation for each study subject consists of the number of recurrent events between successive examinations, are commonly encountered in industrial reliability testing, medical research and other scientific investigations. We formulate the effects of potentially time-dependent covariates on one or more types of recurrent events through nonhomogeneous Poisson processes with random effects. We employ nonparametric maximum likelihood estimation under arbitrary exa...
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作者：Yang, Tao; Huang, Ying; Fong, Youyi
作者单位：Fred Hutchinson Cancer Center
摘要：We consider the use of threshold-based regression models to evaluate immune response biomarkers as principal surrogate markers of a vaccine's protective effect. Threshold-based regression models, which allow the relationship between a clinical outcome and a covariate to change dramatically across a threshold value in the covariate, have been studied by various authors under fully observed data. Limited research, however, has examined these models in the presence of missing covariates, such as ...
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作者：Biscio, C. A. N.; Moller, J.
作者单位：Aalborg University
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作者：Deresa, N. W.; Van Keilegom, I
作者单位：KU Leuven
摘要：When modelling survival data, it is common to assume that the survival time T is conditionally independent of the censoring time C given a set of covariates. However, there are numerous situations in which this assumption is not realistic. The goal of this paper is therefore to develop a semiparametric normal transformation model which assumes that, after a proper nonparametric monotone transformation, the vector (T, C) follows a linear model, and the vector of errors in this bivariate linear ...
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作者：Chung, Moo K.; Ombao, Hernando
作者单位：University of Wisconsin System; University of Wisconsin Madison; King Abdullah University of Science & Technology
