-
作者：Benjamin, MA; Rigby, RA; Stasinopoulos, DM
摘要：A class of generalized autoregressive moving average (GARMA) models is developed that extends the univariate Gaussian ARMA time series model to a flexible observation-driven model for non-Gaussian time series data. The dependent variable is assumed to have a conditional exponential family distribution given the past history of the process. The model estimation is carried out using an iteratively reweighted least squares algorithm. Properties of the model, including stationarity and marginal mo...
-
作者：Tzeng, JY; Byerley, W; Devlin, B; Roeder, K; Wasserman, L
作者单位：Carnegie Mellon University; University of California System; University of California Irvine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC
摘要：We define a statistic, called the matching statistic, for locating regions of the genome that exhibit excess similarity among cases when compared to controls. Such regions are reasonable candidates for harboring disease genes. We find the asymptotic distribution of the statistic while accounting for correlations among sampled individuals. We then use the Benjamini and Hochberg false discovery rate (FDR) method for multiple hypothesis testing to find regions of excess sharing. The p values for ...
-
作者：Landrum, MB; Normand, SLT; Rosenheck, RA
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard T.H. Chan School of Public Health; Yale University
摘要：Quantitative performance monitoring of health care providers has become an increasingly prominent activity in health care delivery. As a consequence, multidimensional report cards comparing the quality of services provided by diverse health care organizations have begun to appear. We present a case study examining the performance of 22 geographically defined health care systems, known as Veterans Integrated Service Networks; involving the treatment of more than 37,000 veterans discharged from ...
-
作者：Greenland, S
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：This article examines the potential for misleading inferences from conventional analyses and sensitivity analyses of observational data, and describes some proposed solutions based on specifying prior distributions for uncontrolled sources of bias. The issues are illustrated in a sensitivity analysis of confounding in a study of residential wire code and childhood leukemia and in a pooled analysis of 12 studies of magnetic-field measurements and childhood leukemia. Both analyses have been inte...
-
作者：Rosenthal, JS
作者单位：University of Toronto
摘要：This article considers nearly-periodic Markov chains that may have excellent functional estimation properties but poor distributional convergence rate. It shows how simple modifications of the chain (involving using a random number of iterations) can greatly improve the distributional convergence of the chain. Various theoretical results about convergence rates of the modified chains are proven. A number of examples, including a transdimensional Markov chain Monte Carlo example, a card-shuffli...
-
作者：Gilbert, S
作者单位：Southern Illinois University System; Southern Illinois University
摘要：In one-way analysis of variance, a main interest is in differences among the groups that comprise the population. For a given parameter, such as a mean value, data yield parameter estimates for each group, as well as group rankings based on these statistics. Here ranking probabilities are studied under the assumption that parameter estimates are well approximated by a normal distribution, either in finite samples or asymptotically, with possible intergroup heteroscedasticity and correlation. P...
-
作者：Dunson, DB; Colombo, B
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); University of Padua
摘要：Cervical mucus hydration increases during the fertile interval before ovulation. Because sperm. can only penetrate mucus having a high water content, cervical secretions provide a reliable marker of the fertile days of the menstrual cycle. This article develops a Bayesian approach for modeling of daily observations of cervical mucus and applies the approach to assess heterogeneity among women and cycles from a given woman with respect to the increase in mucus hydration during the fertile inter...
-
作者：Gupta, M; Liu, JS
作者单位：Harvard University
摘要：Detection of unknown patterns from a randomly generated sequence of observations is a problem arising in fields ranging from signal processing to computational biology. Here we focus on the discovery of short recurring patterns (called motifs) in DNA sequences that represent binding sites for certain proteins in the process of gene regulation. What makes this a difficult problem is that these patterns can vary stochastically. We describe a novel data augmentation strategy for detecting such pa...
-
作者：Straf, ML
作者单位：National Academies of Sciences, Engineering & Medicine
摘要：New technologies benefit our lives in many ways, but they can also bring increased risks, disruptions to our society, and even the malevolence of war. Statisticians can play a critical role in influencing the paths along which technology will take our society. But taking on this role requires changing our discipline, our profession, and our ASA. Change, however, is not an option; if we do not change, then technology may force change on us in detrimental ways. Understanding how to change requir...
-
作者：Dass, SC; Nair, VN
作者单位：Michigan State University; University of Michigan System; University of Michigan
摘要：Situations with incomplete multivariate spatial data on a lattice are considered. The goal is to impute the missing data in the presence of edges or boundaries and recover the image. Two methods based on Bayesian hierarchical models that iterate between edge detection and spatial smoothing to impute the missing data within identified homogeneous regions are examined. Their performance is compared with another method that imputes the missing values using edge-preserving spatial smoothers with l...
