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作者：Johnson, WO
作者单位：University of California System; University of California Davis
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作者：Reilly, C; Wang, CC; Rutherford, M
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
摘要：One of the more challenging, yet easily overlooked, aspects of the analysis of microarrays is how to normalize arrays so that comparisons can be made across arrays. Most studies that utilize microarrays to detect differential gene expression between samples find the data only enable one to conclude that a handful of genes are differentially expressed. The basic idea here is to use the genes that are not differentially expressed to conduct the normalization. Of course, because one cannot determ...
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作者：Tarpey, T; Petkova, E; Ogden, RT
作者单位：University System of Ohio; Wright State University Dayton; Columbia University
摘要：Identification of placebo responders among subjects treated with active drug has significant clinical and research implications. In clinical practice, when a patient treated with medication improves, this improvement may be attributed to the chemical component of the drug itself, a placebo effect, or some combination of these. Determining the proper subsequent treatment and maintenance of the patient may be greatly aided by understanding the mechanism of patient improvement. In a research cont...
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作者：Hjort, NL; Claeskens, G
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作者：Berger, JO; De Oliveira, V; Sansó, B; Ren, CR; Wittig, TA
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作者：Clyde, M; George, EI
作者单位：Duke University; University of Pennsylvania
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作者：Guo, WS; Dai, M; Ombao, HC; von Sachs, R
作者单位：University of Pennsylvania; University of Illinois System; University of Illinois Urbana-Champaign; Universite Catholique Louvain
摘要：In this article we propose a smoothing spline ANOVA model (SS-ANOVA) to estimate and to make inference on the time-varying logspectrum of a locally stationary process. The time-varying spectrum is assumed to be smooth in both time and frequency. This assumption essentially turns a time-frequency spectral estimation problem into a 2-dimensional surface estimation problem. A smooth localized complex exponential (SLEX) basis is used to calculate the initial periodograms, and a SS-ANOVA is fitted ...
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作者：Morris, JS; Vannucci, M; Brown, PJ; Carroll, RJ
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作者：Zhang, CM
作者单位：University of Wisconsin System; University of Wisconsin Madison
摘要：Curve fitting and curve checking based on the local polynomial regression technique are commonly used data-analytic methods in statistics. This article examines, in nonparametric settings, both the asymptotic expressions and empirical formulas for degrees of freedom (DF), a notion introduced by Hastie and Tibshirani, of linear smoothers. The asymptotic results give useful insights into the nonparametric modeling complexity. Meanwhile, by substituting the exact DFs by the empirical formula, an ...
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作者：Benjamin, MA; Rigby, RA; Stasinopoulos, DM
摘要：A class of generalized autoregressive moving average (GARMA) models is developed that extends the univariate Gaussian ARMA time series model to a flexible observation-driven model for non-Gaussian time series data. The dependent variable is assumed to have a conditional exponential family distribution given the past history of the process. The model estimation is carried out using an iteratively reweighted least squares algorithm. Properties of the model, including stationarity and marginal mo...
