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作者：Biedermann, Stefanie; Dette, Holger; Zhu, Wei
作者单位：Ruhr University Bochum; State University of New York (SUNY) System; Stony Brook University
摘要：In close-response studies, the dose range is often restricted because of concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose-response curve for a restricted or unrestricted dose range with respect to a broad class of optimality criteria. The underlying curve belongs to a diversified set of link functions suitable for the dose-response studies and having a common canonical form. These include the fundamental binary response models-the logit ...
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作者：Lu, Guobing; Ades, A. E.
作者单位：University of Bristol
摘要：Randomized comparisons among several treatments give rise to an incomplete-blocks structure known as mixed treatment comparisons (MTCs). To analyze such data structures, it is crucial to assess whether the disparate evidence sources provide consistent information about the treatment contrasts. In this article we propose a general method for assessing evidence inconsistency in the framework of Bayesian hierarchical models. We begin with the distinction between basic parameters, which have prior...
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作者：Heard, NA; Holmes, CC; Stephens, DA
作者单位：Imperial College London; University of Oxford; MRC Harwell
摘要：Malaria represents one of the major worldwide challenges to public health. A recent breakthrough in the study of the disease follows the annotation of the genome of the malaria parasite Plasmodium falciparum and the mosquito vector (an organism that spreads an infectious disease) Anopheles. Of particular interest is the molecular biology underlying the immune response system of Anopheles, which actively fights against Plasmodium infection. This article reports a statistical analysis of gene ex...
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作者：Lin, DY; Zeng, D
作者单位：University of North Carolina; University of North Carolina Chapel Hill
