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作者：Dunson, David B.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
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作者：Small, Dylan S.; Ten Have, Thomas R.; Rosenbaum, Paul R.
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：In the Prospect Study, in 10 pairs of two primary-care practices, one practice was picked at random to receive a depression care manager to treat its depressed patients. Randomization inference, properly performed, reflects the assignment of practices, not patients, to treatment or control. Yet, pertinent data describe individual patients: depression outcomes, baseline covariates, compliance with treatment. The methods discussed use only (i) the random assignment of clusters to treatment or co...
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作者：Calder, Catherine A.; Holloman, Christopher H.; Bortnick, Steven M.; Strauss, Warren; Morara, Michele
作者单位：University System of Ohio; Ohio State University; Battelle Memorial Institute
摘要：Since the U.S. Environmental Protection Agency began widespread monitoring of PM2.5 (particulate matter <2.5 mu in diameter) concentration levels in the late 1990s, the epidemiological community has performed several observational studies directly relating PM2.5 concentration to various health endpoints including mortality and morbidity. However, recent research suggests that human exposure to the constituents of PM2.5 may differ significantly from ambient (or outdoor) PM2.5 concentration meas...
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作者：Crainiceanu, Ciprian M.; Diggle, Peter J.; Rowlingson, Barry
作者单位：Johns Hopkins University; Lancaster University; Lancaster University
摘要：We present a state-of-the-art application of smoothing for dependent bivariate binomial spatial data to Loa loa prevalence mapping in West Africa. This application starts with the nonspatial calibration of survey instruments, continues with the spatial model building and assessment, and ends with robust, tested software intended for use by field workers for online prevalence map updating. From a statistical perspective, we address several important methodological issues: building spatial model...
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作者：Sabatti, Chiara; Lange, Kenneth
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：Affymetrix's SNP (single-nucleotide polymorphism) genotyping chips have increased the scope and decreased the cost of gene-mapping studies. Because each SNP is queried by multiple DNA probes, the chips present interesting challenges in genotype calling. Traditional clustering methods distinguish the three genotypes of an SNP fairly well given a large enough sample of unrelated individuals or a training sample of known genotypes. This article describes our attempt to improve genotype calling by...
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作者：Zhang, Heping; Ye, Yuanqing; Diggle, Peter; Shi, Jian
作者单位：Yale University; Jiangxi Normal University; Lancaster University; Johns Hopkins University; Chinese Academy of Sciences; Academy of Mathematics & System Sciences, CAS
摘要：Exposure to ambient pollutants at concentrations above defined standards is a risk factor for respiratory symptoms, especially in sensitive children. Many studies have been undertaken to monitor air quality and to assess its association with respiratory symptoms. We propose a joint mixed-effects regression model of time series measures and recurrent events to analyze the air quality and respiratory symptom data from the Yale Mothers and Infants Health Study. Three mothers' symptoms (runny nose...
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作者：Tu, Yufeng; Ball, Michael O.; Jank, Wolfgang S.
作者单位：University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park
摘要：In this article we develop a model for estimating flight departure delay distributions required by air traffic congestion prediction models. We identify and study major factors that influence flight departure delays, and develop a strategic departure delay prediction model. This model employs nonparametric methods for daily and seasonal trends. In addition, the model uses a mixture distribution to estimate the residual errors. To overcome problems with local optima in the mixture distribution,...
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作者：Faes, Christel; Geys, Helena; Molenberghs, Geert; Aerts, Marc; Cadarso-Suarez, Carmen; Acuna, Carlos; Cano, Monica
作者单位：Hasselt University; Universidade de Santiago de Compostela
摘要：Neurons can transmit information about the characteristics of a stimulus through the spike rate of neurons and synchronization of the neurons. Various association measure can be used to describe how synchronous two spike trains are. We propose a new measure of synchrony, the conditional synchrony measure, which is the probability of firing together given that at least one of the two neurons is active. Focus is on the specification of a flexible marginal model for multivariate correlated binary...
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作者：Aldrich, John
作者单位：University of Southampton
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作者：Nordman, Daniel J.; Caragea, Petruta C.
作者单位：Iowa State University
摘要：We present a spatial blockwise empirical likelihood method for estimating variogram model parameters in the analysis of spatial data on a grid. The method produces point estimators that require no spatial variance estimates to compute, unlike least squares methods for variogram fitting, but are as efficient as the best least squares estimator in large samples. Our approach also produces confidence regions for the variogram, without requiring knowledge of the full joint distribution of the spat...
