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作者：Hung, Ying; Zarnitsyna, Veronika; Zhang, Yan; Zhu, Cheng; Wu, C. F. Jeff
作者单位：Rutgers University System; Rutgers University New Brunswick; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
摘要：Repeated adhesion frequency assay is the only published method for measuring the kinetic rates of cell adhesion. Cell adhesion plays an important role in many physiological and pathological processes. Traditional analysis of adhesion frequency experiments assumes that the adhesion test cycles are independent Bernoulli trials. This assumption often can be violated in practice. Motivated by the analysis of repeated adhesion tests, a binary time series model incorporating random effects is develo...
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作者：Dunson, David B.; Xue, Ya; Carin, Lawrence
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); General Electric; Duke University
摘要：In analyzing data from multiple related studies, it often is of interest to borrow information across studies and to cluster similar studies. Although parametric hierarchical models are commonly used, of concern is sensitivity to the form chosen for the random-effects distribution. A Dirichlet process (DP) prior can allow the distribution to be unknown, while clustering studies; however, the DP does not allow local clustering of studies with respect to a subset of the coefficients without maki...
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作者：van Soest, Arthur; Hurd, Michael
作者单位：RAND Corporation; Tilburg University
摘要：We analyze experimental survey data, with a random split into respondents who get an open-ended question on the amount of total family consumption (with follow-up unfolding brackets of the form Is consumption $X or more? for those who answer don't know or refuse) and respondents who are immediately directed to unfolding brackets. In both cases, the entry point of the unfolding bracket sequence is randomized. Allowing for any type of selection into answering the open-ended or bracket questions,...
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作者：Small, Dylan S.; Rosenbaum, Paul R.
作者单位：University of Pennsylvania
摘要：An instrument manipulates a treatment that it does not entirely control, but the instrument affects the outcome only indirectly through its maipulation of the treatment. The idealized prototype is the randomized encouragement design, in which subjects are randomly assigned to receive either encouragement to accept the treatment or no such encouragement, but not all subjects comply by doing what they are encouraged to do, and the situation is such that only the treatment itself, not disregarded...
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作者：Guha, Subharup; Li, Yi; Neuberg, Donna
作者单位：University of Missouri System; University of Missouri Columbia; Harvard University; Harvard T.H. Chan School of Public Health
摘要：Genomic alterations have been linked to the development and progression of cancer. The technique of comparative genomic hybridization (CGH) yields data consisting of fluorescence intensity ratios of test and reference DNA samples. The intensity ratios provide information about the number of copies in DNA. Practical issues such as the contamination of tumor cells in tissue specimens and normalization errors necessitate the use of statistics for learning about the genomic alterations from array ...
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作者：Crainiceanu, Ciprian M.; Diggle, Peter J.; Rowlingson, Barry
作者单位：Johns Hopkins University; Lancaster University; Lancaster University
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作者：Zabell, S. L.
作者单位：Northwestern University; Northwestern University
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作者：Iversen, Edwin S.; Parmigiani, Giovanni; Chen, Sining
作者单位：Duke University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
摘要：We describe a method for evaluating an ensemble of predictive models given a sample of observations comprising the model predictions and the outcome event measured with error. Our formulation allows us to simultaneously estimate measurement error parameters, true outcome-the gold standard-and a relative weighting of the predictive scores. We describe conditions necessary to estimate the gold standard and to calibrate these estimates and detail how our approach is related to, but distinct from,...
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作者：Rodriguez, Abel; Dunson, David B.; Gelfand, Alan E.
作者单位：University of California System; University of California Santa Cruz; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Duke University
摘要：In multicenter studies subjects in different centers may have different outcome distribution. This article is motivated by the problem of nonparametric modeling of these distributions, borrowing information across centers while also allowing centers to be clustered, Starting with a stick-breaking representation of the Dricichlet process (DP). we replace that random atoms with random probability measures drawn from a DP. This results in a nested DP prior, which can be placed on the collection o...
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作者：Cizek, Pavel
作者单位：Tilburg University
摘要：The binary-choice regression models, such as probit and logit, are used to describe the effect of explanatory variables on a binary response variable. Typically estimated by the maximum likelihood method, estimates are very sensitive to deviations from a model, such as heteroscedasticity and data contamination. At the same time, the traditional robust (high-breakdown point) methods, such as the maximum trimmed likelihood, are not applicable because, by trimming observations, they induce nonide...
