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作者：Gramacy, Robert B.; Lee, Herbert K. H.
作者单位：University of Cambridge; University of California System; University of California Santa Cruz
摘要：Motivated by a computer experiment for the design of a rocket booster this article explores nonstationary modeling methodologies that couple stationary Gaussian processes with treed partioning is a simple but effective method for dealing with nonstationarity. The methodological developments and statistical computing details that make this approach efficient are described in detail. In addition to providing an analysis of the rocket booster, we show that our approach is effective in other areas...
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作者：Chen, Jianwei; Wu, Hulin
作者单位：California State University System; San Diego State University; University of Rochester
摘要：Recently deterministic dynamic models have become very popular in biomedical research and other scientific areas; examples include modeling human immunodeficiency virus (HIV) dynamics, pharmacokinetic/pharmacodynamic analysis, tumor cell kinetics, and genetic network modeling. In this article we propose estimation methods for the time-varying coefficients in deterministic dynamic systems that are usually described by a set of differential equations. Three two-stage local polynomial estimators ...
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作者：Hyrien, Ollivier; Zand, Martin S.
作者单位：University of Rochester; University of Rochester
摘要：Recent advances in flow cytometry have resulted in the development of powerful bioassays to analyze the proliferation of cell populations. The carboxy-fluorescein diacetate succinimidyl ester (CFSE)-labeling experiment is one such assay that is widely used to study cell kinetics and as a standard tool for investigating lymphocyte proliferation. Several mathematical models have been proposed to describe cell proliferation during CFSE experiments. The statistical analysis of CFSE-labeling data h...
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作者：Paciorek, Christopher J.
作者单位：Harvard University; Harvard T.H. Chan School of Public Health
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作者：Stigler, Stephen M.
作者单位：University of Chicago
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作者：Lidong, E.; Hannig, Jan; Iyer, Hari
作者单位：Colorado State University System; Colorado State University Fort Collins
摘要：In this article we propose a new method for constructing confidence intervals for sigma(2)(alpha), sigma(2)(epsilon), and the interclass correlation rho = sigma(2)(alpha)/(sigma(2)(alpha)+sigma(2)(epsilon)) in a two-component mixed-effects linear model. This method is based on an extension of R. A. Fisher's fiducial argument. We conducted a simulation study to compare the resulting interval estimates with other competing confidence interval procedures from the literature. Our results demonstra...
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作者：Dasgupta, Tirthankar; Ma, Christopher; Joseph, V. Roshan; Wang, Z. L.; Wu, C. F. Jeff
作者单位：Harvard University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
摘要：We systematically investigate the best process conditions that ensure synthesis of different types of one-dimensional cadmium selenide nanostructures with high yield and reproducibility. Through a designed experiment and rigorous statistical analysis of experimental data, models linking the probabilities of obtaining specific morphologies to the process variables are developed. A new iterative algorithm for fitting a multinomial generalized linear model is proposed and used. The optimum proces...
